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The first engineering of cell surfaces in living animals

ld be injected into organs to seek out cells with certain glycosylation patterns" -- patterns of cell-surface sugars characteristic of cancerous cells, for example, or sites of inflammation.

Not only does the demonstration of the Staudinger ligation in mice suggest a range of diagnostic and therapeutic possibilities, the Staudinger ligation itself may be only the first of what Bertozzi calls "a future arsenal of chemical reactions used to probe the biology of living animals."


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Contact: Paul Preuss
paul_preuss@lbl.gov
510-486-6249
DOE/Lawrence Berkeley National Laboratory
18-Aug-2004


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