HOME >> BIOLOGY >> NEWS
The genetics of aging: New study says cell division errors may be the common link

La Jolla CA., March 31, 2000 -- Gradual genetic changes may be the source of many, if not all illnesses of aging, including breast cancer, osteoporosis, Alzheimer's disease and arthritis. A new study by scientists in The Skaggs Institute for Chemical Biology at The Scripps Research Institute (TSRI) in La Jolla and the Genomics Institute of the Novartis Research Foundation, published in the latest issue of Science, concludes that human aging and its associated diseases and conditions can be traced to a gradual increase in cell division errors in tissues throughout the body. This functional change begins slowly in middle age and increases gradually with advancing age.

According to Richard A. Lerner, M.D., an author of the paper, "Mitotic Misregulation and Human Aging," "This represents a radical change in the way people have thought about aging. While scientists have believed that aging is a disease in which cells stop dividing, this study suggests that aging is really a disease of quality control. In this case the manufactured product is a new cell. As we get older, altered gene expression results in cells with diminished function." Dr. Lerner is TSRI President, Lita Annenberg Hazen Professor of Immunochemistry, Cecil H. and Ida M. Green Chair in Chemistry, and Professor in The Skaggs Institute for Chemical Biology and the Department of Chemistry. Cell Division Errors are Key

Errors in cell division lead to the altered expression of a collection of key genes in the cells. Altered gene expression gradually causes the loss of tissue function which results in aging. Unlike cancers, in which cells are uniformly dysfunctional, aging occurs in a mosaic pattern, at different rates in different parts of the body. "Our research ties the effects of aging into a single package by identifying a common element in aging tissues throughout the body," Dr. Lerner continued.

Dr. Lerner noted that, "The Human Genome Project is biology's particle physics experiment. Beca
'"/>

Contact: Robin B. Goldsmith
rgoldsmi@scripps.edu
858-784-8134
Scripps Research Institute
29-Mar-2000


Page: 1 2 3

Related biology news :

1. Chemical genetics identifies SARS inhibitors
2. Adaptive changes in the genome may provide insight into the genetics of complex disease
3. Length of sex act in flies dictated by genetics
4. Scientists suggest framework for epigenetics in common disease
5. Skin condition linked to genetics in Caucasian and Chinese populations
6. Study identifies genetics of fat metabolism, red wine link
7. Innovative efforts target epigenetics, molecular imaging
8. Hopkins to found first center for comprehensive study of epigenetics
9. Biologists discover nerve activity, not just genetics controls kinds of neurotransmitters produced
10. Pioneer in the genetics of programmed cell death honored
11. Human evolution at the crossroads: Integrating genetics and paleontology

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/6/2019)... ... 05, 2019 , ... MedTech Breakthrough , an independent ... medical technology market, announced that it has selected Medacta International’s MySpine® MC platform ... the 2019 MedTech Breakthrough Awards program. , Medacta® is an ...
(Date:6/4/2019)... Calif. (PRWEB) , ... June 04, 2019 , ... Harper ... was limping. X-rays revealed severe elbow dysplasia, which caused painful osteoarthritis in the ... her elbows. Her parents were heartbroken. , The surgical specialist, Dr. Christopher Eich ...
(Date:5/31/2019)... ... May 29, 2019 , ... FileWave, the multi-platform endpoint management ... launch of version 13.1. The new version extends FileWave’s mobile device management features ... spring release functionality. Version 13.1 builds on FileWave’s version 13 that was released ...
Breaking Biology News(10 mins):
(Date:5/4/2019)... ... May 03, 2019 , ... Diopsys Inc, the ... ffERG/Photopic Negative Response vision test, a new full field electroretinography (ffERG) protocol ... that 6.3 million Americans will have glaucoma, with black Americans having the highest ...
(Date:5/2/2019)... ... May 02, 2019 , ... Researchers ... present results documenting discrepancies between U.S. insurer policies for genetic testing and the ... for hereditary breast and ovarian cancer (HBOC). , Jill S. Dolinsky, ...
(Date:4/18/2019)... WORCESTER, Mass. (PRWEB) , ... April 18, 2019 ... ... for fossil fuels, a research team that includes a chemical engineer at Worcester ... an exotic microorganism that may make it possible to manufacture isobutanol and other ...
(Date:4/12/2019)... ... April 12, 2019 , ... An ... and will educate about innovative tools and devices being used to enhance cognitive ... more information. , This segment of Advancements will focus on Sound for Life, ...
Breaking Biology Technology:
Cached News: