HOME >> BIOLOGY >> NEWS
The growing Staphylococcus aureus arsenal

Staphylococcus aureus is an opportunistic pathogen with a diverse battery of virulence factors, each of which can act alone or in concert in the development of persistent and sometimes lethal infections such as sepsis, toxic shock syndrome, food poisoning and severe skin diseases.

Staphylococcal infections begin when the organism gains access to host tissues or the adjoining blood supply through breaches in the skin. More than 20% of healthy humans are natural carriers of S. aureus, 10%-20% of these carriers harbor multidrug-resistant strains, and the frequencies of both community-acquired and hospital-acquired staphylococcal infections continue to increase. Disturbingly, our stockpile of antibiotics is not evolving at a rate capable of quelling the uprising of resistance.

Determining whether an infection is contained or succeeds in spreading is a complex battle between defensive cells of the patient's immune system and the onslaught of the array of enzymes, toxins and other injurious factors released by the bacterium. During early stages of infection the S. aureus expresses proteins that enable its binding to, and colonization of, host tissue. Following establishment within the host, other toxins and enzymes help the staphylococci spread to nearby tissue and begin the process of colonization over and over again.

In the November 18 issue of the Journal of Clinical Investigation Eric Brown and colleagues from the Texas A&M University Health Science Center further investigate the role of another interesting member of the S. aureus artillery. The MHC class II Analog Protein (known as Map) was shown to interfere with the function of T cells, a patient's most specific defense against foreign intruders, which appeared to promote the persistence and survival of S. aureus in infected mice.


'"/>

Contact: Brooke Grindlinger, PhD
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
19-Nov-2002


Page: 1

Related biology news :

1. Symposium examines the growing influence of aerosols on climate
2. Report details growing climate change threat to coral reefs
3. Eastern Europe urged to prepare now for growing threat of HIV resistance
4. Nerac again named one of Connecticuts fastest growing technology companies
5. UMHS researchers find clues to growing new jawbones in cancer patients after radiation therapy
6. New findings in yeast may reveal why growing older is the greatest carcinogen in humans
7. Long-term natural gas supplies should meet growing demand in coming decades, study finds
8. Carnegie Mellon develops new process for growing bone
9. Faster method for growing adult stem cells for bone regeneration developed at Hebrew University
10. New study: percentage of babies born with intestinal birth defect growing in U.S., N.C.
11. Pathogenic yeasts and fungi: A growing health concern

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/26/2017)... CITY , Jan. 26, 2017  Crossmatch, a ... unveiled a new solution aimed at combatting fraud, waste ... solution was introduced at the Action on Disaster Relief ... key meeting point for UN agencies and foreign assistance ... Fraud, waste and abuse are a largely unacknowledged ...
(Date:1/24/2017)... Jan. 24, 2017 Biopharm Reports has ... laboratory use of nuclear magnetic resonance spectroscopy (NMR). ... and profiled current practices, developments, trends and end-user ... as growth and opportunities. These areas include growth ... instruments, needs and innovation requirements, hyphenated NMR techniques, ...
(Date:1/21/2017)... Research and Markets has announced the addition of the "Global ... ... recognition biometrics market to grow at a CAGR of 19.36% during ... scenario and the growth prospects of the global voice recognition biometrics ... the revenue generated from the sales of voice recognition biometrics including ...
Breaking Biology News(10 mins):
(Date:2/21/2017)... FRANCISCO , Feb. 21, 2017   Invitae ... genetic information companies, today announced that members of the ... Company 37th Annual Health Care Conference on Monday, March ... p.m. Pacific in Boston, Massachusetts . ... presentation may be accessed by visiting the investors section ...
(Date:2/20/2017)... , Feb. 20, 2017 /PRNewswire/ - BioAmber Inc. (NYSE: BIOA ... President and CEO and Fabrice Orecchioni, the company,s COO, has been ... COO over the past four years, Fabrice has overseen the construction, ... and the management of the Mitsui JV.  Fabrice has ... the proposed China JV. ...
(Date:2/20/2017)... ... 20, 2017 , ... Salford-based Mettler Toledo Safeline, which employs ... processing and packaging industries, was runner-up for the Environmental Achievement Award, sponsored by ... or taken the most innovative steps to improve its environmental performance. , ...
(Date:2/20/2017)... ... February 20, 2017 , ... ... chest wall collapses in pre-term infants with respiratory distress, and assist surgeons ... $600,000 in funding through the ninth round of the University City Science ...
Breaking Biology Technology:
Cached News: