HOME >> BIOLOGY >> NEWS
The growing Staphylococcus aureus arsenal

Staphylococcus aureus is an opportunistic pathogen with a diverse battery of virulence factors, each of which can act alone or in concert in the development of persistent and sometimes lethal infections such as sepsis, toxic shock syndrome, food poisoning and severe skin diseases.

Staphylococcal infections begin when the organism gains access to host tissues or the adjoining blood supply through breaches in the skin. More than 20% of healthy humans are natural carriers of S. aureus, 10%-20% of these carriers harbor multidrug-resistant strains, and the frequencies of both community-acquired and hospital-acquired staphylococcal infections continue to increase. Disturbingly, our stockpile of antibiotics is not evolving at a rate capable of quelling the uprising of resistance.

Determining whether an infection is contained or succeeds in spreading is a complex battle between defensive cells of the patient's immune system and the onslaught of the array of enzymes, toxins and other injurious factors released by the bacterium. During early stages of infection the S. aureus expresses proteins that enable its binding to, and colonization of, host tissue. Following establishment within the host, other toxins and enzymes help the staphylococci spread to nearby tissue and begin the process of colonization over and over again.

In the November 18 issue of the Journal of Clinical Investigation Eric Brown and colleagues from the Texas A&M University Health Science Center further investigate the role of another interesting member of the S. aureus artillery. The MHC class II Analog Protein (known as Map) was shown to interfere with the function of T cells, a patient's most specific defense against foreign intruders, which appeared to promote the persistence and survival of S. aureus in infected mice.


'"/>

Contact: Brooke Grindlinger, PhD
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
19-Nov-2002


Page: 1

Related biology news :

1. Symposium examines the growing influence of aerosols on climate
2. Report details growing climate change threat to coral reefs
3. Eastern Europe urged to prepare now for growing threat of HIV resistance
4. Nerac again named one of Connecticuts fastest growing technology companies
5. UMHS researchers find clues to growing new jawbones in cancer patients after radiation therapy
6. New findings in yeast may reveal why growing older is the greatest carcinogen in humans
7. Long-term natural gas supplies should meet growing demand in coming decades, study finds
8. Carnegie Mellon develops new process for growing bone
9. Faster method for growing adult stem cells for bone regeneration developed at Hebrew University
10. New study: percentage of babies born with intestinal birth defect growing in U.S., N.C.
11. Pathogenic yeasts and fungi: A growing health concern

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: The growing Staphylococcus aureus arsenal

(Date:8/1/2014)... of a new study, including two Simon Fraser ... industry representatives and policymakers must collaborate closely on ... gas development. Viorel Popescu and Maureen Ryan, David ... Sciences department, are among eight international co-authors of ... Ecology and the Environment . , Shale gas ...
(Date:7/31/2014)... AMHERST, Mass. A first-of-its-kind study of bigeye tuna ... Lutcavage, director of the Large Pelagics Research Center at ... that these fish cover a wide geographical range with ... shelf, and they favor a high-use area off Cape ... research, which used a new approach to study one ...
(Date:7/31/2014)... Latinos are the largest minority group in the United ... of Latinos are obese and are 1.2 times as ... , NYU College of Nursing student researcher Lauren Gerchow, ... factors that contribute to this problem by compiling a ... patterns in Latina women recently published in Nursing ...
Breaking Biology News(10 mins):Scientists warn time to stop drilling in the dark 2Scientists warn time to stop drilling in the dark 3Study of bigeye tuna in Northwest Atlantic uses new tracking methods 2Study of bigeye tuna in Northwest Atlantic uses new tracking methods 3NYU research looks to combat US Latina immigrant obesity 2
(Date:8/1/2014)... , Aug. 1, 2014 Research ... "The World Market for Flow Cytometry in ... http://photos.prnewswire.com/prnh/20130307/600769 ... are now an important component of advanced IVD ... instruments for cancer diagnostics, but their newer clinical ...
(Date:8/1/2014)... , Aug. 1. 2014 As one ... the 2014 AACC Annual Meeting & Clinical Lab Expo ... and patient care are introduced to the healthcare world. ... the Expo,s 650 exhibitors will include the latest diagnostic ... Advances in smartphones and biosensors have enabled the ...
(Date:8/1/2014)... , Aug. 1, 2014 One of the ... of personalized medicine, which is the practice of using ... to a patient,s individual biology. Personalized diagnostics—laboratory analyses that ... role in the lab,s future. This fall, AACC ... the latest science in this exciting field and the ...
(Date:8/1/2014)... , August 1, 2014 According ... Research "Biophotonics Market - Global Industry Analysis, Size, Share, ... was valued at USD 25.16 billion in 2013, which ... growing at a CAGR of 10.4% from 2014 to ... at  http://www.transparencymarketresearch.com/biophotonics-market.html Increasing demand for accurate ...
Breaking Biology Technology:The World Market for Flow Cytometry in IVD Applications 2Lab-on-a-Chip Technology to Be Featured at 2014 AACC Annual Meeting & Clinical Lab Expo 2Lab-on-a-Chip Technology to Be Featured at 2014 AACC Annual Meeting & Clinical Lab Expo 3First-Ever AACC Virtual Conference to Focus on Personalized Diagnostics 2Global Biophotonics Market is Expected to Reach USD 50.20 Billion in 2020: Transparency Market Research 2Global Biophotonics Market is Expected to Reach USD 50.20 Billion in 2020: Transparency Market Research 3Global Biophotonics Market is Expected to Reach USD 50.20 Billion in 2020: Transparency Market Research 4
Cached News: