HOME >> BIOLOGY >> NEWS
The immune system may be involved in the susceptibility to childhood attention deficit hyperactivity disorder (ADHD)

Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, characterized by inattention, hyperactivity and impulsivity. It affects 4- 10% of school age children, exacting a significant clinical and public health toll. ADHD constitutes one of the main reasons for referral to neurological/psychiatric treatment in this age group, and results in exposure of many children to prolonged courses of stimulant medication such as Ritalin. Untreated, ADHD may lead to impairments in schooling and social adaptation in a critical period of development, eventuating in damage to the childs self esteem and personality development, with high rates of depression, conduct disorder, school dropouts, and substance abuse. The causes of ADHD are unknown. Current theories suggest altered brain activity of chemical transmitters such as dopamine and norepinepherine may play a role. This is based on pharmacological observations showing reduction in symptoms in response to stimulant drugs such as Ritalin which augment dopaminergic and noradrenergic activity in relevant brain areas. However, current findings evade simplistic neurochemical explanations.

Family studies suggest a major heritable contribution to ADHD, but the mode of inheritance remains obscure. To date, the search for actual genes involved focused mainly on the dopamine system, with some findings suggesting a possible involvement of dopaminergic genes in risk for ADHD.

The current study, is the first to report the possible involvement of a gene encoding a modulator of the immune system in ADHD. Recent evidence supports the involvement of immune modulators in brain processes outside the realm of their classical role in inflammatory responses. One of the major modulators, interleukin 1 (IL-1) is expressed in the adult brain, and plays a role in maintaining neural plasticity, neuroprotection, and response to non immune stressors. Recent theories suggest it may be involved in ps
'"/>

Contact: Karl Lorenzen
molecularpsychiatry@mednet.ucla.edu
310-206-6739
Molecular Psychiatry
7-Jan-2002


Page: 1 2

Related biology news :

1. Long-term effects of carbon monoxide poisoning are an autoimmune reaction
2. Probing the surface of white blood cells to enhance immune system medicine
3. Researchers uncover secrets of immune systems munitions factory
4. Regular physical activity really does boost immune system in older men
5. New model can aid in understanding immune system diseases
6. New mechanism for display of foreign proteins to immune system
7. Babies with DiGeorge syndrome saved by immune supression, thymus transplant
8. Researchers develop better understanding of immune response to viral infection
9. Patients cells from tumors, the immune system merged for customized cancer therapy
10. Triple-vaccine strategy stimulates strong HIV-specific immune response in monkeys
11. Lack of immune system protein prevents lupus-like condition in mice

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2017)... KONG , March 30, 2017 The ... a system for three-dimensional (3D) fingerprint identification by adopting ground breaking ... into a new realm of speed and accuracy for use in ... at an affordable cost. ... ...
(Date:3/29/2017)... March 29, 2017  higi, the health IT company ... North America , today announced a Series ... acquisition of EveryMove. The new investment and acquisition accelerates ... tools to transform population health activities through the collection ... higi collects and secures data today on ...
(Date:3/27/2017)... ROCKVILLE CENTRE, N.Y. , March 27, 2017 ... by Healthcare Information and Management Systems Society (HIMSS) ... Analytics Outpatient EMR Adoption Model sm . In ... top 12% of U.S. hospitals using an electronic ... recognized CHS for its high level of EMR ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... BioMedGPS announces ... addition of its newest module, US Hemostats & Sealants. , SmartTRAK’s US Market ... hemostats, fibrin sealants, synthetic sealants and biologic sealants used in surgical applications. BioMedGPS ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... launched Rosalind™, the first-ever genomics analysis platform specifically designed for life science ... in honor of pioneering researcher Rosalind Franklin, who made a major contribution ...
(Date:10/11/2017)... ... October 11, 2017 , ... The CRISPR-Cas9 ... enabling overexpression experiments and avoiding the use of exogenous expression plasmids. The simplicity ... for performing systematic gain-of-function studies. , This complement to loss-of-function studies, such ...
(Date:10/11/2017)... ... October 11, 2017 , ... ComplianceOnline’s Medical Device Summit ... 7th and 8th June 2018 in San Francisco, CA. The Summit brings together current ... several distinguished CEOs, board directors and government officials from around the world to address ...
Breaking Biology Technology:
Cached News: