HOME >> BIOLOGY >> NEWS
The magic behind merlin

A new study reveals an essential role for the merlin protein in maintaining the junctions between cells a significant advance in understanding the tumor suppressor function of this protein, and how mutations in the gene that encodes it can contribute to cancer.

The report is published by Dr. Andrea McClatchey and colleagues at the MGH Cancer Center (Charlestown, MA) and INSERM (Paris, France) in the May 1 issue of Genes & Development.

The merlin protein is encoded by the NF2 gene. Mutations in NF2 cause neurofibromatosis type 2, a hereditary cancer syndrome characterized by a predisposition to develop tumors of the central nervous system. Although NF2 was cloned a decade ago, this paper by Dr. McClatchey and colleagues provides unprecedented insight into the biological consequences of merlin loss and therefore its role in tumorigenesis.

Dr. McClatchey and colleagues have determined that merlin resides in adherens junctions the mechanical attachments that connect adjacent cells. In addition to providing support and rigidity to tissues, adherens junctions are also necessary for contact-mediated growth inhibition, the property of cells to cease proliferating once they occupy the space allotted to them and come in contact with other cells and/or a dense extracellular environment.

"We found that merlin normally controls the way cells communicate with each other; merlin-deficient cells cannot 'sense' each other and continue to divide when there is no more room," states Dr. McClatchey.

Dr. McCatchey and colleagues used Nf2-deficient mouse cells to demonstrate that the absence of merlin results in the destabilization of adherens junctions and the subsequent loss of contact-mediated growth inhibition. The researchers were able to observe Nf2-deficient cells piling up on top of each other, seemingly immune to the contact-mediated growth arrest signal. However, the exogenous expression of merlin protein in Nf2-deficient cells is suf
'"/>

Contact: Heather Cosel
coselpie@cshl.org
Cold Spring Harbor Laboratory
18-Apr-2003


Page: 1 2

Related biology news :

1. Researchers describe long-perplexing magic spot on bacteria
2. Card tricks and mathematics: Applying the magicians trade to numerical dilemmas
3. Microbes work magic on hazardous air pollutants
4. Secret behind hard exoskeletons, spreading wings revealed
5. Nations plant database falling behind, survey shows
6. Researchers developing radar technology to detect mold behind walls
7. Cellular problems found behind complex obesity syndrome
8. Envisat fishes up facts behind Chilean giant squid invasion
9. Biology behind homosexuality in sheep, study confirms
10. No cow left behind
11. Duke researchers discover power behind molecular motors

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/10/2020)... Va. (PRWEB) , ... July 08, 2020 , ... ... Latest on Cell and Gene Therapy Regulation, An FDAnews Webinar, Wednesday, July 22, ... need a comparability study, but what is the most effective way to complete ...
(Date:7/2/2020)... ... July 02, 2020 , ... Dutch ... the use of its revolutionary NEXTGENPCR endpoint thermocycler to test for SARS-CoV-2 ... The article, titled "Ultra-fast one-step RT-PCR protocol for the detection of SARS-CoV-2," ...
(Date:6/28/2020)... JUPITER, Fla. (PRWEB) , ... June 25, 2020 , ... ... will focus on innovations in accelerated Point of Care Testing solutions (POCT). Check local ... labs. Samples are collected at medical offices and are shipped to labs throughout the ...
Breaking Biology News(10 mins):
(Date:7/18/2020)... (PRWEB) , ... July 16, 2020 , ... After research ... The completion of a great surgery is only the beginning of a successful study, ... research community. , Join Brad Gien, Global Head of Surgery from Envigo ...
(Date:7/18/2020)... ... 16, 2020 , ... Medial EarlySign , a leader ... of high-burden diseases, and Centric Consulting, a business and technology consulting firm, today ... data in order to identify and prioritize patients for care. , Combining Centric’s ...
(Date:7/10/2020)... Va. (PRWEB) , ... July 08, 2020 , ... ... testing services and products, announces a significant expansion of laboratory operations through its ... collection for agencies implementing testing programs. , Bode-CARES provides a ...
(Date:7/10/2020)... ... July 09, 2020 , ... In most research using ... suppress pigment formation in zebrafish embryos, maintaining optical transparency to facilitate microscopic imaging. ... has been using the zebrafish model to investigate the causes of leukaemia and ...
Breaking Biology Technology:
Cached News: