HOME >> BIOLOGY >> NEWS
The masculinization of the X chromosome: many genes for early male sperm production reside on the X chromosome

In an entirely counterintuitive result, scientists have found that nearly half of all genes related to the earliest stages of sperm production reside not on the male sex (Y) chromosome as expected, but on the X chromosome, a chromosome universally thought of as the female sex chromosome.

The finding, published in the April issue of Nature Genetics, comes as a big surprise and is causing scientists to rethink the "gender identity" of the X chromosome.

"Scientists and non-scientists alike are comfortable thinking about the Y chromosome as a specialist in male characteristics. By default, weve traditionally thought of the X chromosome as sexually neutral or as a specialist in female characteristics. Our findings indicate that the X chromosome has a specialty in sperm production, much like the Y chromosome does," says David Page, lead author on the paper and a researcher at the Whitehead Institute for Biomedical Research and Howard Hughes Medical Institute.

The finding also raises the speculation that infertility due to low sperm production may be an X-linked disorder, passed on to male children through their mothers, much like color-blindness or hemophilia.

In this study, the Page lab researchers and their colleague John McCarrey at Southwest Foundation for Biomedical Research, in San Antonio, Texas, sought to study the genetic underpinnings of spermatogonia-stem cells in the testes that give rise to sperm. Spermatogonia are "the mother of all sperm cells," but unlike other stem cells, such as blood stem cells, which have been the subject of intense study, sperm stem cells have remained largely unexplored. So Jeremy Wang, a postdoctoral fellow in the Page lab, and his colleagues conducted a systematic search for genes that are active exclusively in sperm stem cells in mice.

The researchers found 25 genes, including 19 new ones, that were expressed exclusively in mouse sperm stem cells. They found that of these, only 3 were linked to the Y
'"/>

Contact: Nadia Halim
halim@wi.mit.edu
617-258-9183
Whitehead Institute for Biomedical Research
28-Mar-2001


Page: 1 2 3

Related biology news :

1. Belgian researchers explore revolutionary approach to angiogenesis
2. Tracing genes, biologists show lizard migration is traced to Florida
3. Certain genes boost fish oils protection against breast cancer
4. Fossil genes reveal how life sheds form and function
5. Missing genes may help explain why plague bacteria are so deadly
6. Do genes respond to global warming?
7. Genetic map of important tree genes outlined
8. Mitochondrial genes cause nuclear mischief
9. Identifying tick genes could halt disease, bioterrorism threat
10. A genetic disorder yields insight into genes and cognition
11. Mouse study shows NPAS3 and NPAS1 genes may be linked to psychosis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: