HOME >> BIOLOGY >> NEWS
The mother lode of mutations

Philadelphia, PA -- After five years and thousands of zebrafish breeding experiments, Mary C. Mullins, PhD, associate professor of cell and developmental biology at the University of Pennsylvania School of Medicine and colleagues have published a description of dozens of mutations that will help determine the earliest steps in vertebrate development, which take the spherical embryo to a complex creature. These discoveries are described in a pair of papers in the June Developmental Cell and are featured on the cover of that issue. In time, these discoveries may help researchers understand human sterility and fertility problems, as well as what causes certain birth defects.

Molecular control of the step-by-step process of how the zebrafish body unfolds relies to some extent on maternally driven processes. These depend on proteins derived only from the egg, which are critical to embryonic development prior to the activation of the new embryo's own genome. In vertebrates, maternal gene products direct such essential processes as fertilization; the first cellular divisions of the embryo; and the head-to-tail arrangement of developing cells. The genes also control morphogenetic movement, the migration of cells to form the three-dimensional structure of the embryo.

In 1998 the Mullins lab embarked on a large-scale maternal-effect mutant screen, not previously performed in a vertebrate animal model. In addition to the 68 maternal mutations, through inbreeding studies, they also discovered five paternally derived mutations. Daniel S. Wagner, PhD, and Roland Dosch, PhD, both postdoctoral fellows in the Mullins lab, spent five-plus years each on this intensive research project.

"These maternal processes are well-studied in invertebrates, but not vertebrates," says Mullins. "Genetic screens have been extremely powerful in identifying key genes and understanding the processes involved." This collection of mutants p
'"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
23-Jun-2004


Page: 1 2 3

Related biology news :

1. The search for a kinder, gentler chemotherapy
2. New survey reveals insights into unique relationship between mothers and pediatricians
3. Study shows impact of emotionally healthy fathers when mothers poor mental health affects children
4. Drug prevents chemotherapy-induced hearing loss, study finds
5. Living at home helps young mothers stay in school
6. Structure solved at Scripps shows how one human protein reduces potency of chemotherapy
7. ALL survivors bear genetic damage from life-saving chemotherapy
8. Scientist honored for studies of genetic influence on chemotherapy, tumor development
9. New York City study shows newborns more susceptible to pollution than their mothers
10. Gene therapy tested to protect bone marrow during chemotherapy
11. Researchers identify genetic markers to predict response to chemotherapy for colorectal cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2017)... -- Veratad Technologies, LLC ( www.veratad.com ), an innovative and ... solutions, announced today they will participate as a sponsor ... May 17, 2017, in Washington D.C.,s ... Identity impacts the lives of billions of ... digital world, defining identity is critical to nearly every ...
(Date:5/6/2017)... SINGAPORE , May 5, 2017 ... has just announced a new breakthrough in biometric ... that exploits quantum mechanical properties to perform ... new smart semiconductor material created by Ram Group ... across finance, entertainment, transportation, supply chains and security. ...
(Date:4/19/2017)... , April 19, 2017 ... its vendor landscape is marked by the presence of ... is however held by five major players - 3M ... these companies accounted for nearly 61% of the global ... leading companies in the global military biometrics market boast ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... The CRISPR-Cas9 system ... experiments and avoiding the use of exogenous expression plasmids. The simplicity of programming ... systematic gain-of-function studies. , This complement to loss-of-function studies, such as with ...
(Date:10/11/2017)... ... October 11, 2017 , ... ComplianceOnline’s Medical Device Summit is back for ... June 2018 in San Francisco, CA. The Summit brings together current and former FDA ... board directors and government officials from around the world to address key issues in ...
(Date:10/11/2017)... -- VMS BioMarketing, a leading provider of patient support solutions, has ... (CNE) network, which will launch this week. The VMS CNEs ... professionals to enhance the patient care experience by delivering peer-to-peer ... care professionals to help women who have been diagnosed and ... ...
(Date:10/11/2017)... ... ... Disappearing forests and increased emissions are the main causes of the evolving ... those living in larger cities are affected by air pollution related diseases. , That ... countries globally - decided to take action. , “I knew I had to take ...
Breaking Biology Technology:
Cached News: