HOME >> BIOLOGY >> NEWS
The path to a folded protein, long a subject of debate, appears in many cases to be long and winding

PHILADELPHIA Its a long-simmering debate in the world of physical chemistry: Does the folding of proteins into biologically active shapes better resemble a luge run fast, linear and predictable or the more freeform trajectories of a ski slope? New research from the University of Pennsylvania offers the strongest evidence yet that proteins shimmy into their characteristic shapes not via a single, unyielding route but by paths as individualistic as those followed by skiers coursing from a mountain summit down to the base lodge.

The new support for a more heterogeneous model of protein folding comes in a paper published today on the Web site of the Proceedings of the National Academy of Sciences.

"The traditional view has been that a protein passes through a series of fixed reactions to reach its folded state," said senior author Feng Gai, a Penn chemist. "Our work suggests quite strongly that folding is a far richer phenomenon. Like skiers, some proteins rocket down an energy gradient to their destination while others take their time, meandering indiscriminately."

Though a fleeting phenomenon, the folding of gangly proteins into tight three-dimensional shapes has broad implications for the growing group of human diseases believed to result from misfolded proteins, most notably neurodegenerative disorders such as Alzheimers and Parkinsons diseases. The characteristic plaques that cripple the brains of Alzheimers and Parkinsons patients are believed to be the dumping grounds for aberrant proteins.

Gais work subtly shifts scientists understanding of one possible remedy: molecular chaperones, promising compounds that "rescue" misfolded proteins and are believed capable of blocking the progression of neurodegenerative disease. Rather than giving sluggish proteins the oomph to finish folding, the Penn work indicates that chaperones may return misfolded proteins to an unfolded state so they can start all over again.

"In the s
'"/>

Contact: Steve Bradt
bradt@pobox.upenn.edu
215-573-6604
University of Pennsylvania
26-Feb-2002


Page: 1 2

Related biology news :

1. Unraveling a protein, researchers uncover mechanics of anti-cancer agent
2. Oral contraceptives increase C-reactive protein, an infIammatory biomarker
3. Statins may prevent damage by Alzheimers disease protein, USF study finds
4. Mice with human protein, COX-2, exhibit age-related memory loss similar to Alzheimers disease
5. Consuming more protein, less carbohydrates may be healthier
6. The protection of human subjects in gene transfer research explored at conference in July
7. Latest findings on PCBs to be subject of June workshop at Illinois
8. NIEHS and UNC to collaborate on registry of 20,000 subjects
9. Clock cells, tumor suicide, tailored therapies among subjects of AACR-NCI-EORTC Conference
10. DNA profiling is subject of two-day expert forum at Wright State
11. Embryonic facial development subject to insult or repair longer than expected

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/31/2020)... ... July 30, 2020 , ... ... therapeutics product portfolio with a near term focus on Type 2 diabetes and ... commercialization experience across multiple therapeutic areas and classes. As Chief Commercial Officer, Justin ...
(Date:7/10/2020)... ... July 08, 2020 , ... ... and Gene Therapy Regulation, An FDAnews Webinar, Wednesday, July 22, 2020 • 1:30 ... study, but what is the most effective way to complete one? Will the ...
(Date:7/2/2020)... ... July 02, 2020 , ... ... publication detailing the use of its revolutionary NEXTGENPCR endpoint thermocycler to test ... 16 minutes. The article, titled "Ultra-fast one-step RT-PCR protocol for the detection ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... MIAMI (PRWEB) , ... July 29, 2020 , ... ... nearly 200 of the top radiation centers in 16 countries, has reached its ... years, SDX® is now in routine use at top universities including University of ...
(Date:7/18/2020)... ... July 16, 2020 , ... ... aid in the early detection and prevention of high-burden diseases, and Centric Consulting, ... hospitals and healthcare organizations to utilize existing data in order to identify and ...
(Date:7/10/2020)... Mass. (PRWEB) , ... July 09, 2020 , ... ... approaches to cell therapy, today announced the hiring of Allen R. Nissenson, M.D., ... team and oversee the clinical development of Sentien’s lead product, SBI-101. Dr. ...
(Date:7/1/2020)... , ... June 30, 2020 ... ... tissue data insights, today announced that the launch of a new ... with data about the tumor microenvironment (TME). , “Flagship’s TissueInsight is a ...
Breaking Biology Technology:
Cached News: