HOME >> BIOLOGY >> NEWS
The silence of the clones: new link between DNA replication and 'silent' chromosome architecture

Cold Spring Harbor, NY -- As genetically identical cells (such as those in an embryo) multiply, different sets of genes are switched on, and others off, giving rise to cells and tissues with distinctive properties (e.g. liver versus muscle). Such differential gene expression is determined in part by the large-scale architecture or chromatin structure of DNA. "Silent" regions of DNA are tightly packaged into forms of chromatin that are less accessible to transcriptional activators, the proteins that switch genes on. Active regions of DNA adopt alternate chromatin structures that are generally more accessible to transcriptional activators .

Now, Bruce Stillman and his colleagues at Cold Spring Harbor Laboratory have demonstrated how a set of proteins work in concert to duplicate both the basic sequence of DNA as well as silenced states of chromatin structure. The findings, published tomorrow in Nature, provide the first detailed mechanism to explain how both DNA sequences and their associated states of gene expression are coordinately passed on to future generations of cells.

In 1989, Stillman and his colleague Susan Smith (now at New York University Medical School) purified a human protein called chromatin assembly factor-1 (CAF-1). They showed that in a test tube, CAF-1 could wrap newly-synthesized DNA around chromosomal proteins called histones, forming "beads on a string." Such structures are the first level of higher order chromatin structure beyond naked DNA. "Beads on a string" (nucleosomes) can be wrapped into still higher orders of chromatin structure, ultimately yielding tightly compacted chromosomal domains that are transcriptionally silent.

Consistent with CAF-1's ability to assemble chromatin in cell free systems, Stillman and his colleagues subsequently found that CAF-1 is required for the inheritance of silenced domains of DNA in an intact organism (yeast). Both humans and yeast, and indeed all complex organisms, contain rel
'"/>

Contact: Peter W. Sherwood, Ph.D.
sherwood@cshl.org
516-367-6947
Cold Spring Harbor Laboratory
7-Nov-2000


Page: 1 2 3

Related biology news :

1. To understand innate immunity, silence the genome
2. The silence of the genes
3. Reversing the sounds of silence
4. NYU biologists develop better way to silence neurons
5. Breaking the silence: Discovery could lead to new treatments for cancer, sickle-cell anemia
6. Rett Syndrome traced to defective gene silencer
7. Landmark agreement between Samoa and UC Berkeley could help search for AIDS cure
8. New research suggests link between maternal diet and childhood leukemia risk
9. Fossils reveal direct link between global warming and genetic diversity in wildlife
10. Battle between bubbles might have started evolution
11. UCSD researchers are first to demonstrate molecular link between inflammation and cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/5/2019)... TORONTO (PRWEB) , ... January 04, 2019 , ... ... Chief Architect – two experts in Healthcare & Life Sciences from MarkLogic – ... EST (4pm GMT). , This presentation outlines the challenges of using real world ...
(Date:1/4/2019)... ... January 03, 2019 , ... Over the last few years, ... discovery research workflows with biology ranging from single cell-type spheroids to highly complex ... studies, they create several challenges that need to be overcome in order to ...
(Date:12/27/2018)... ... December 27, 2018 , ... AxioMed completed its ... Boston facility, and is now raising growth capital to ramp up demand for ... against inferior ball and socket discs. The capital raise is targeted to qualified ...
Breaking Biology News(10 mins):
(Date:12/5/2018)... (PRWEB) , ... December 05, 2018 , ... Leading authority ... an all-new, how-to guide with his “The Referral Playbook: How to Increase Sales ... of the book proceeds will go to the Alzheimer’s Foundation of America (AFA). ...
(Date:12/5/2018)... ... December 05, 2018 , ... STRmix™ – sophisticated forensic software ... – has been used to convict a Wyoming man of third-degree sexual assault, a ... used STRmix™ to test for DNA on the couch cushions on which the sexual ...
(Date:11/29/2018)... ... November 29, 2018 , ... RAGS, today announced the closing ... Seed Fund, with participation from existing investor and board member Jeremy Andrus, CEO of ... Cotopaxi. The additional funding will enable the company to accelerate its growth and expand ...
(Date:11/27/2018)... , ... November 27, 2018 , ... New patients in ... Dr. Dan Myers’ practice for treatment, with or without a referral. Dr. Myers has ... tools, including porcelain veneers, dental implants, bridges and custom crowns. , As a ...
Breaking Biology Technology:
Cached News: