HOME >> BIOLOGY >> NEWS
The skin's acid coating: SFVAMC researchers explain its origin and how it maintains skin integrity

Your skin is coated with acid. While that might sound disturbing, the mild acidity of the skin's surface actually helps to maintain the strength and cohesiveness of the skin. Now researchers at SFVAMC have discovered where this acidity comes from, and they suggest how it may help to hold the skin together.

The findings, published in the latest issue of the Journal of Investigative Dermatology, may be used to develop therapies for skin problems such as psoriasis.

For decades scientists have known that the outer layers of the skin are about as acidic as a bowl of crushed tomatoes. This acidity was believed to help ward off infections by preventing the growth of bacteria. But the source of all this acid and how it helped to maintain the skin's strength and integrity, remained a mystery.

In their latest study, Joachim Fluhr, MD, a postdoctoral research fellow at the SFVAMC and UCSF, and his colleagues lead by SFVAMC dermatologist Peter Elias, MD, a UCSF professor of dermatology, tested the hypothesis that the acid is produced when enzymes break down fat-like molecules in skin cells, called phospholipids, into smaller acid-tipped fat molecules called fatty acids.

To test this theory, the researchers used a hairless breed of mice and treated patches of their skin with a chemical that blocks the conversion of phospholipids to fatty acids. They then observed what effect this treatment had on the skin.

The treated skin quickly lost its acidity, and this change also had a negative effect on the skin's integrity, Fluhr said. Treated patches of skin were more susceptible to evaporation and drying than untreated skin, he said.

Furthermore, the reduced acidity also made the skin less cohesive. When the researchers repeatedly applied strips of adhesive tape to the skin, they found that significantly more protein stuck to the tape from the inhibitor treated skin than from normal skin.

"We have shown clearly
'"/>

Contact: Kevin Boyd
kboyd@pubaff.ucsf.edu
415-476-8429
University of California - San Francisco
15-Aug-2001


Page: 1 2

Related biology news :

1. Hair follicles provide the stem cells for the skins entire epidermis
2. SFVAMC study may revive old approach to high blood pressure therapy
3. SFVAMC study explains prostate cancer resistance to hormone therapy
4. Brain damage from HIV, Alzheimers, may have similar mechanism, SFVAMC researchers say
5. Some women may have gene sequence that reduces breast cancer risk, SFVAMC study finds
6. SFVAMC/UCSF researchers develop lead for a new Alzheimers disease drug - a fragment of a brain growth protein
7. SFVAMC-UCSF scientists solve a key protein structure
8. Belgian researchers explore revolutionary approach to angiogenesis
9. Award winning researchers reveal potential new role for Glivec
10. $7.5 Million grant to Yale researchers for role of viruses in cancer
11. New anti-inflammatory strategy for cancer therapy identified by UCSD researchers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/29/2018)... ... August 28, 2018 , ... ... unlocking the full power of positron emission tomography (PET), today launched its ... Dx is helping clinicians and researchers study and cure debilitating diseases, earlier, ...
(Date:8/26/2018)... ... August 24, 2018 , ... ... clinical diagnostic laboratories. However, this technology introduces many well-described challenges around data ... leads the South London NHS Genomic Medicine Centre. The Viapath Genetics Laboratories ...
(Date:8/23/2018)... Calif. (PRWEB) , ... August 21, 2018 , ... ... engineer the genomes of diverse cell types and species for the robust functional ... research tool for the development of T-cell based immunotherapies, the study of the ...
Breaking Biology News(10 mins):
(Date:8/17/2018)... ... August 16, 2018 , ... KCAS Bioanalytical and Biomarker ... expansion of their team. Dr. Dawn Dufield, Ph.D., joins KCAS as Director of ... LC-MS/MS group that will specialize in developing quantitative LC-MS/MS assays for biopharma molecules. ...
(Date:8/17/2018)... ... August 17, 2018 , ... ... and Environmental Repositories (ISBER) is pleased to announce the release of the Russian ... publication, originally released in January 2018, is a practice-changing publication aimed at advancing ...
(Date:8/14/2018)... ... August 14, 2018 , ... ... treating opioid use disorder. BUP is often prescribed as a sublingual co-formulation with ... , In this webinar, participants will learn from a review of the pharmacokinetics ...
(Date:8/11/2018)... ... August 10, 2018 , ... Researchers performing pressurized NMR or EPR experiments face ... Protection Chamber for High-Pressure NMR & EPR by Wilmad-LabGlass – SP Scienceware shields ... , High-pressure experiments have significantly grown in popularity over the last several years. ...
Breaking Biology Technology:
Cached News: