HOME >> BIOLOGY >> NEWS
The skin's acid coating: SFVAMC researchers explain its origin and how it maintains skin integrity

Your skin is coated with acid. While that might sound disturbing, the mild acidity of the skin's surface actually helps to maintain the strength and cohesiveness of the skin. Now researchers at SFVAMC have discovered where this acidity comes from, and they suggest how it may help to hold the skin together.

The findings, published in the latest issue of the Journal of Investigative Dermatology, may be used to develop therapies for skin problems such as psoriasis.

For decades scientists have known that the outer layers of the skin are about as acidic as a bowl of crushed tomatoes. This acidity was believed to help ward off infections by preventing the growth of bacteria. But the source of all this acid and how it helped to maintain the skin's strength and integrity, remained a mystery.

In their latest study, Joachim Fluhr, MD, a postdoctoral research fellow at the SFVAMC and UCSF, and his colleagues lead by SFVAMC dermatologist Peter Elias, MD, a UCSF professor of dermatology, tested the hypothesis that the acid is produced when enzymes break down fat-like molecules in skin cells, called phospholipids, into smaller acid-tipped fat molecules called fatty acids.

To test this theory, the researchers used a hairless breed of mice and treated patches of their skin with a chemical that blocks the conversion of phospholipids to fatty acids. They then observed what effect this treatment had on the skin.

The treated skin quickly lost its acidity, and this change also had a negative effect on the skin's integrity, Fluhr said. Treated patches of skin were more susceptible to evaporation and drying than untreated skin, he said.

Furthermore, the reduced acidity also made the skin less cohesive. When the researchers repeatedly applied strips of adhesive tape to the skin, they found that significantly more protein stuck to the tape from the inhibitor treated skin than from normal skin.

"We have shown clearly
'"/>

Contact: Kevin Boyd
kboyd@pubaff.ucsf.edu
415-476-8429
University of California - San Francisco
15-Aug-2001


Page: 1 2

Related biology news :

1. Hair follicles provide the stem cells for the skins entire epidermis
2. SFVAMC study may revive old approach to high blood pressure therapy
3. SFVAMC study explains prostate cancer resistance to hormone therapy
4. Brain damage from HIV, Alzheimers, may have similar mechanism, SFVAMC researchers say
5. Some women may have gene sequence that reduces breast cancer risk, SFVAMC study finds
6. SFVAMC/UCSF researchers develop lead for a new Alzheimers disease drug - a fragment of a brain growth protein
7. SFVAMC-UCSF scientists solve a key protein structure
8. Belgian researchers explore revolutionary approach to angiogenesis
9. Award winning researchers reveal potential new role for Glivec
10. $7.5 Million grant to Yale researchers for role of viruses in cancer
11. New anti-inflammatory strategy for cancer therapy identified by UCSD researchers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/25/2019)... , ... April 24, 2019 , ... ... announces today the award of U.S. patent 10,191,929, “Systems and Methods for SNP ... and more efficient to conduct a variety of advanced bioinformatic analyses, including SNP ...
(Date:4/18/2019)... and WALNUT CREEK, Calif. (PRWEB) , ... April ... ... management solution for the healthcare industry, today announced the launch of mSource® AI ... processing to extract deep knowledge of Medpricer customers’ supplier contracts, truly optimizing purchased ...
(Date:4/16/2019)... ... April 16, 2019 , ... HealthLink International, experts ... its new medical device facility on Friday, April 12. Headquartered in the Netherlands, ... new facility includes 108,500 square feet and houses 32 employees enabling HealthLink to ...
Breaking Biology News(10 mins):
(Date:5/2/2019)... , ... May 02, 2019 , ... ... testing company, will present results documenting discrepancies between U.S. insurer policies for genetic ... patients at risk for hereditary breast and ovarian cancer (HBOC). , ...
(Date:4/18/2019)... ... April 18, 2019 , ... Taking a step closer ... chemical engineer at Worcester Polytechnic Institute (WPI) has developed a novel process using ... manufacture isobutanol and other biofuels more economically. , Isobutanol, like ethanol, is an ...
(Date:4/12/2019)... ... April 12, 2019 , ... An upcoming episode ... educate about innovative tools and devices being used to enhance cognitive skills. This ... , This segment of Advancements will focus on Sound for Life, a neurotechnology ...
(Date:4/9/2019)... ... April 09, 2019 , ... Sonny Bar Lisa, or Sonny for short, ... two months. After a series of diagnostics, an MRI was performed which revealed ... researched the injury and found that VetStem Regenerative Cell Therapy may be ...
Breaking Biology Technology:
Cached News: