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Third Wave scientists publish advance in gene expression monitoring with revolutionary RNA Invader Assay

small as 1.2-fold or 20 percent, allowing researchers and clinicians to routinely and precisely quantify small but important changes in biologically and medically significant genes.
  • Sensitivity. While the RNA Invader assay can routinely and directly detect as few as 6,000 copies of RNA, a level sufficient for monitoring gene expression, an analytical sensitivity of fewer than 100 copies of HIV-1 RNA was demonstrated.
  • Specificity. The RNA Invader assay not only clearly distinguishes between RNA sequences that are more than 95 percent identical, but can detect the equivalent of a single target sequence in a pool of at least 20,000 sequences of closely related RNA. The majority of existing RNA testing methods have difficulty discriminating between highly similar sequences and, as a result, cannot consistently identify and measure a specific target within a sample of closely related RNAs. RNA is the bodys medium for translating an individuals genetic blueprint, found in ones DNA, into all the proteins in the body, including those that fight disease, metabolize drugs and perform a host of other critical functions. Many gene families, like the important cytochrome P450 family responsible for metabolizing drugs and toxic compounds, generate nearly identical RNA sequences that produce proteins with different functions and effects on the body. The Invader assays ability to discriminate between nearly identical RNA sequences allows researchers to identify a specific RNA target with consistency, accuracy and precision.

    The ease and accuracy in measuring gene expression provided by the RNA Invader assay are vital to accelerating research to understand disease progression and develop new drugs. The assays ability to detect low levels of RNA also provides potential for first detecting and then monitoring the treatment of infectious diseases like HIV more quickly than now possible.

    The Invader technology will ultimately allow h
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  • Contact: Beth Preston
    epreston@fkhealth.com
    617-761-6739
    Feinstein Kean Healthcare
    2-Jul-2001


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