HOME >> BIOLOGY >> NEWS
Third piece completes deadly puzzle: Structure of anthrax toxin offers clues to treatment

Researchers from the University of Chicago and Boston Biomedical Research Institute have described the three-dimensional structure of edema factor, one of the three toxins that make anthrax so deadly. This finding, published in the January 24 issue of Nature, is a crucial step toward designing drugs to block the harmful effects of anthrax and perhaps other bacterial toxins.

Although antibiotics can kill the bacteria, anthrax produces toxins that can cause death even after the bacteria have been eradicated. Since some forms of anthrax infection produce few symptoms until the disease is advanced, physicians need better drugs to counteract these toxins.

"Knowing the structure of edema factor and how it works allows us to design drugs that can block its effects," said Wei-Jen Tang, Ph.D., associate professor in the Ben May Cancer Research Laboratories at the University of Chicago and director of the study.

Anthrax produces three toxins that work together. One, called protective antigen, allows the other two to enter target cells. The second, lethal factor, destroys cells of the immune system. When immune cells die they release inflammatory agents that can cause septic shock, leading to death. The structure for protective antigen was published in February, 1997, and that of lethal factor in November, 2001.

The structure of the third toxin, called edema factor because
'"/>

Contact: John Easton
jeaston@uchospitals.edu
773-702-6241
University of Chicago Medical Center
23-Jan-2002


Page: 1 2 3 4

Related biology news :

1. Popular Science announces Third Annual Brilliant 10
2. Third set of awards are announced under interagency biodiversity program
3. Large brains not required? Third and smallest skull of first Eurasians reported in Science
4. Rutgers scientists create high-protein corn with Third World potential
5. Third Wave scientists publish advance in gene expression monitoring with revolutionary RNA Invader Assay
6. University Of Kentucky Researcher Awarded MERIT Extension For Study Of Third World Killer
7. Third Annual Awards For Presidential Green Chemistry Challenge Recognize Innovations
8. Fortified Drink Improves Third World Nutrition
9. New research shows plants can shuffle and paste gene pieces to generate genetic diversity
10. Building the whole cell from pieces
11. The dopamine receptor D1 gene and ADHD: A piece of the genetic puzzle?

Post Your Comments:
(Date:7/23/2014)... crucial for providing essential fatty acids and energy ... There has been concern that soybean-based emulsions could ... to its composition. Combination lipid emulsions based on ... been developed to address this concern. , However, ... concern may be unwarranted, according to a review ...
(Date:7/22/2014)... research from the Monell Center reveals that simply believing ... inflammation in asthmatics for at least 24 hours following ... play in health-related outcomes. , "Asthmatics often are anxious ... odor is harmful, our bodies react as if that ... Jan, PhD, a Monell physiologist. "Both patients and care ...
(Date:7/22/2014)... survival rates of 12 different shark species when ... found large differences in survival,rates across the 12 ... being the most,vulnerable. The study, led by researchers ... of,Marine and Atmospheric Science and UM Abess Center ... consider for future conservation measures for sharks in ...
Breaking Biology News(10 mins):In asthma, it's not just what you smell, but what you think you smell 2In asthma, it's not just what you smell, but what you think you smell 3New study reveals vulnerability of sharks as collateral damage in commercial fishing 2
(Date:7/22/2014)... Piscataway, NJ (PR Web) July 21, 2014 (PRWEB) ... Jersey Center for Biomaterials, at Rutgers University. ... exchange information and ideas across the full spectrum ... focusing on selected research and development topics that ... application. Activities have been programmed to:, ...
(Date:7/22/2014)... Dr. Terry Baughn, a senior lecturer in mechanical engineering ... named Engineer of the Year by the North Texas ... , ASME has more than 130,000 members in 158 ... share technology to assist the engineering community, benefiting the ... the Texas Society of Professional Engineers honors banquet. Baughn ...
(Date:7/22/2014)... 2014 Rice Lake Weighing ... 2014 NCSL International Workshop and Symposium July 28-31 ... CONDEC pressure instrumentation, OIML M1 weights, precision lab ... customized sets, Essential Weights™. , NCSL International was ... in solving the common problems faced by measurement ...
(Date:7/22/2014)... CAMBRIDGE, Massachusetts og SHENZHEN ... BGI Tech Solutions Co., LTD, (BGI Tech), et ... globale lancering af en ny human whole exome-sekvenseringstjeneste ... Complete Genomics, højt anset i branchen for ... og højfølsom registrering af alle typer varianter, blev ...
Breaking Biology Technology:The 2014 NJ Symposium on Biomaterials Science Earns Society for Biomaterials Endorsement 2UT Dallas professor receives Engineer of the Year award 2Rice Lake Weighing Systems Showcases Metrology Solutions for the 2014 NCSL International Workshop & Symposium 2BGI Tech lancerer Human Whole Exome-sekvenseringstjeneste på Complete Genomics avancerede platform 2
Cached News: