HOME >> BIOLOGY >> NEWS
Third piece completes deadly puzzle: Structure of anthrax toxin offers clues to treatment

Researchers from the University of Chicago and Boston Biomedical Research Institute have described the three-dimensional structure of edema factor, one of the three toxins that make anthrax so deadly. This finding, published in the January 24 issue of Nature, is a crucial step toward designing drugs to block the harmful effects of anthrax and perhaps other bacterial toxins.

Although antibiotics can kill the bacteria, anthrax produces toxins that can cause death even after the bacteria have been eradicated. Since some forms of anthrax infection produce few symptoms until the disease is advanced, physicians need better drugs to counteract these toxins.

"Knowing the structure of edema factor and how it works allows us to design drugs that can block its effects," said Wei-Jen Tang, Ph.D., associate professor in the Ben May Cancer Research Laboratories at the University of Chicago and director of the study.

Anthrax produces three toxins that work together. One, called protective antigen, allows the other two to enter target cells. The second, lethal factor, destroys cells of the immune system. When immune cells die they release inflammatory agents that can cause septic shock, leading to death. The structure for protective antigen was published in February, 1997, and that of lethal factor in November, 2001.

The structure of the third toxin, called edema factor because
'"/>

Contact: John Easton
jeaston@uchospitals.edu
773-702-6241
University of Chicago Medical Center
23-Jan-2002


Page: 1 2 3 4

Related biology news :

1. Popular Science announces Third Annual Brilliant 10
2. Third set of awards are announced under interagency biodiversity program
3. Large brains not required? Third and smallest skull of first Eurasians reported in Science
4. Rutgers scientists create high-protein corn with Third World potential
5. Third Wave scientists publish advance in gene expression monitoring with revolutionary RNA Invader Assay
6. University Of Kentucky Researcher Awarded MERIT Extension For Study Of Third World Killer
7. Third Annual Awards For Presidential Green Chemistry Challenge Recognize Innovations
8. Fortified Drink Improves Third World Nutrition
9. New research shows plants can shuffle and paste gene pieces to generate genetic diversity
10. Building the whole cell from pieces
11. The dopamine receptor D1 gene and ADHD: A piece of the genetic puzzle?

Post Your Comments:
(Date:5/21/2015)... The Sync Project™ , a global collaboration harnessing ... a collaborative partnership with Berklee,s Institute for Creative ... on original research, joint course development and an internship ... Sync Project and BerkleeICE are exploring the launch of ... academic year.  The course will focus ...
(Date:5/19/2015)... Fingerprint Cards (FPC) has received an order for ... from one if its module partners. Deliveries are planned to ... the sensors will be used by smartphone manufacturers in ... amount to 740 MSEK to date. In addition to previously ... number of smaller orders not separately communicated amounting to more ...
(Date:5/18/2015)... , May 18, 2015 Fingerprint ... sensors FPC1020, FPC1025, FPC1145, FPC1155 and FPC1035 from one if ... June until and including Q3 2015 and the sensors will ... . Communicated order values for 2015 hereby amount to 740 ... Q1 2015 of 140 MSEK and a number of smaller ...
Breaking Biology News(10 mins):The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 2The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 3Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2
(Date:5/21/2015)... Patent Offering, The patent’s technology pertains ... therapeutic imaging within a body lumen (open space). ... a low cost, single-use disposable illumination and camera module ... 18, 2013 and the patent approval was received on ... to customize the lighting and magnification of the endoscope ...
(Date:5/21/2015)... Ontario (PRWEB) May 21, 2015 ... into an exclusive North American distribution agreement with ... testing system. , With more than 160 years ... products and services for laboratory and production facilities, ... operational excellence and differentiated services to enable science. ...
(Date:5/20/2015)... , May 19, 2015 Research and Markets ... the "Global Cell Therapy Market Outlook 2020 " ... cell therapy in tissue and regenerative medicine is expected ... other options which could help in the growth of ... segment but they are unable to form new tissue ...
(Date:5/20/2015)... YORK , May 20, 2015  Marc ... a leadership gift of $100 million from The ... create a new laboratory building that will be ... extension. The Marie-Josée and Henry R. Kravis Research ... the FDR Drive, spanning approximately three city blocks ...
Breaking Biology Technology:IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 2IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 3Veolia’s TECTA™ B16 Instrument for E. Coli Detection is Offered Exclusively Through VWR 2Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 2Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 3The Marie-Josee and Henry R. Kravis Foundation Provides Landmark Gift of $100 Million to The Rockefeller University 2The Marie-Josee and Henry R. Kravis Foundation Provides Landmark Gift of $100 Million to The Rockefeller University 3The Marie-Josee and Henry R. Kravis Foundation Provides Landmark Gift of $100 Million to The Rockefeller University 4
Cached News: