HOME >> BIOLOGY >> NEWS
Three areas on chromosomes contain prostate cancer aggressive genes

Prostate cancer is the most common cancer among U.S. males. It is the second leading cause of cancer death -- trailing only lung cancer -- in that group. In the year 2000, approximately 180,400 men nationally will be diagnosed with prostate cancer, a disease accounting for about 31,900 deaths annually.

Little is currently known about what makes some prostate cancer biologically aggressive and more likely to progress to metastatic and potentially lethal disease. One compelling possibility is that genetic factors help drive the mechanisms underlying prostate cancer aggressiveness.

Now, for the first time, researchers have taken a direct measure of prostate cancer aggressiveness in a genome-wide scan. The results, which appear in the July issue of the "American Journal of Human Genetics," suggest three candidate regions that give evidence for linkage to prostate cancer aggressive genes. They are located on chromosomes 5q, 7q, and 19q.

"This indicates that one or more of these candidate regions may contain genes that influence the progression of prostate cancer from latent to invasive disease," said John S. Witte, lead author and associate professor of epidemiology and biostatistics at Case Western Reserve University's School of Medicine. "Identifying such genes would be extremely valuable for elucidating the biologic mechanisms underlying prostate cancer progression and for determining treatment in men diagnosed with the disease," he said.

The researchers ranked cancer aggressiveness with the Gleason score, a key pathological measure assigned to a prostate tumor. Gleason score reflects the patterns of tissue architecture observed by a pathologist in two prostate biopsy or surgical samples.

Low Gleason scores indicate that the tumor cells are well differentiated and organized into glandular structures. In contrast, higher scores signify less differentiation of the tumor cells: they appear solid and dissipate together. Poor differentiati
'"/>

Contact: George Stamatis
gxs18@po.cwru.edu
216-368-3635
Case Western Reserve University
26-Jul-2000


Page: 1 2

Related biology news :

1. Three new South American fish identified
2. Three personal ads for physics
3. Three molecular-targeted compounds show promise against cancers
4. Three genes linked to psoriasis susceptibility identified on chromosome 17
5. Three Pacific Northwest National Laboratory inventions win R&D 100 Awards
6. Three Gorges Dam is an opportunity for ecoscience
7. Three tourist experiences named best worldwide for environmental, social responsibility
8. Three inferior prefrontal regions of the brain found receptive to somatosensory stimuli
9. Three dimensional structure of a protein transport machine
10. Three studies released this week shed new light on eating nuts for good health
11. Three nations agree to share ice core thatmay yield clues about nature of Lake Vostok

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: