HOME >> BIOLOGY >> NEWS
Timing of chemical signal critical for normal emotional development

A signaling protein suspected of malfunctioning in anxiety and mood disorders plays a key role in the development of emotional behavior, report researchers funded by the National Institute of Mental Health. Mice lacking it in frontal brain circuits during an early critical period fail to develop normal reactions in anxiety-producing situations.

Rene Hen, Ph.D., Columbia University, and colleagues created mice that lacked the protein, which brain cells use to receive signals from the chemical messenger serotonin, by knocking-out the gene that codes for it. As adults, these "knockout" mice were slow to venture into -- or eat in -- unfamiliar environments. By selectively restoring, or "rescuing" certain populations of the receptor proteins, the researchers have now pinpointed when and where they enable the brain to cope with anxiety. Hen, Cornelius Gross, Ph.D., Xiaoxi Zhuang, Ph.D, and colleagues report on their discovery in the March 28, 2002 Nature.

Brain neurons communicate with each other by secreting messenger chemicals, such as serotonin, which cross the synaptic gulf between cells and bind to receptors on neighboring cell membranes. Medications that enhance such binding of serotonin to its receptor (serotonin selective reuptake inhibitors, or SSRIs) are widely prescribed to treat anxiety and depression, suggesting that the receptor plays an important role in regulating these emotions.

Behavior of the animals in the study mimicked human anxiety. The mice bred not to express the gene that codes for the serotonin receptor (5-HT1A) moved around less than normal animals in open spaces, balked at entering elevated mazes, and were slower to begin eating in such novel environments. Yet, the researchers didn't know which of two populations of serotonin receptors -- one in the forebrain and another deep in the brainstem -- was responsible. To find out, they crossed the receptor knockout mice with mice engineered to turn receptor expres
'"/>

Contact: Jules Asher
NIMHpress@nih.gov
301-443-4536
NIH/National Institute of Mental Health
27-Mar-2002


Page: 1 2 3

Related biology news :

1. Vanderbilt Researcher: Human Brain Has Great Sense Of Timing
2. When To Reproduce? Its All In The Timing
3. DNA lends scientists a hand, revealing new chemical reactions
4. Grant advances biochemical engineering laboratory
5. Bullish chemical could repel yellow fever mosquitoes
6. Computer database being developed at Temple will allow for better inventory of chemicals
7. Cleaner water, more efficient electricity among UH chemical research
8. New world record magnet for chemical and biomedical research
9. Common chemicals morphing into potential toxins in Arctic
10. PTC Therapeutics researchers identify biochemical pathway important for modulating cell growth
11. Research finds lawn chemicals raise cancer risk in Scottish terriers

Post Your Comments:
(Date:10/31/2014)... New Haven, Conn. – Geologists are letting the air out ... on Earth. , Scientists have long speculated as to why ... Earth,s surface. Animals began to prosper at the end of ... what about the billion-year stretch before that, when most researchers ... seems the air wasn,t so great then, after all. , ...
(Date:10/31/2014)... good for attracting species, but it may not be enough ... study has found. , The researchers surveyed two types of ... abundance of two insects that interact with them. They found ... and black walnut, they didn,t find a corresponding abundance of ... the walnuts and black cherries and a type of wasp ...
(Date:10/31/2014)... Melbourne researchers have uncovered key steps involved in programmed ... diseases including lupus, cancers and neurodegenerative diseases. , ... Institute worked together to discover the three-dimensional structure of ... the first steps in how it causes cell death. ... and Proceedings of the National ...
Breaking Biology News(10 mins):Lack of oxygen delayed the rise of animals on Earth 2Green spaces don't ensure biodiversity in urban areas 2A matter of life and death: Cell death proteins key to fighting disease 2
(Date:10/31/2014)... Brady (NYSE:BRC), a global ... a new video testimonial on the effectiveness ... a research technician at the BloodCenter of Wisconsin discusses ... and storing hundreds of thousands of samples, and how ... , “At Brady, we design our label materials with ...
(Date:10/31/2014)... 2014  Tavistock Development Co. (TDC), a diversified ... groundbreaking of the GuideWell Innovation Center ... The 92,000-square-foot, three-story facility is the first multi-tenant ... designed specifically for life sciences, health innovation, and ... 650-acre Lake Nona Medical City, near the Sanford-Burnham ...
(Date:10/30/2014)... Investor-Edge has initiated coverage on the following ... (NASDAQ: MDVN ), Pharmacyclics Inc. (NASDAQ: ... and Ironwood Pharmaceuticals Inc. (NASDAQ: IRWD). Free research on ... . On Wednesday, October 29, 2014, the ... Jones Industrial Average declined 0.18%, to finish the day ...
(Date:10/30/2014)... Dallas, Texas (PRWEB) October 30, 2014 ... China Naltrexone HCL Industry” is a professional and ... The report provides basic Naltrexone HCL information, including ... as well as industry overview. This research covers ... as well as global industry analysis covering macroeconomic ...
Breaking Biology Technology:Brady Debuts New Lab Label Testimonial Video 2GuideWell Innovation Center Groundbreaking Hosted by Tavistock Development Company at Lake Nona Medical City 2GuideWell Innovation Center Groundbreaking Hosted by Tavistock Development Company at Lake Nona Medical City 3Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 2Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 3Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 4Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 5Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 2Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 3
Cached News: