Tiny, magnetic spheres may help overcome gene therapy hurdle

GAINESVILLE, Fla. --- The average person's heart pumps about a gallon of blood per minute, a rate that can easily triple or quadruple during exercise.

The rapid flow of blood through the body is a major roadblock to the use of gene therapy to cure diseases. When injected into the blood, vector viruses which carry corrective genes tend to shoot past the target organ or tissue rather than sticking to it, like grains of sand moving past stones in a fast-flowing river.

Now, University of Florida gene therapy and biomedical engineering researchers have demonstrated a novel approach to the problem. In a July article in Molecular Therapy, they report attaching the adeno-associated virus, a widely used gene carrier, to the surface of tiny manufactured balls known as microspheres, each containing a miniscule particle of iron oxide. Using a magnet placed under culture dishes, the researchers were able to coax large amounts of the microspheres to target areas of the cultures. In related experiments in mice, the researchers showed the microspheres clung to cells or organs longer than the virus alone did.

The procedure, reminiscent of the toy that moves magnetized objects beneath transparent plastic, could someday evolve into a treatment that would enable doctors to guide corrective gene-containing microspheres injected into a patient with magnets placed outside the skin. Such procedures, could, for example, replace invasive catheterizations used to treat lung and heart diseases, the researchers said.

"By packaging the virus with the microsphere, we both guided it to the targeted area and got it to stick there," said Barry Byrne, the lead researcher and a pediatric cardiologist with the UF College of Medicine who is affiliated with the UF Genetics Institute.

Byrne and Cathryn Mah, an assistant research professor in the department of pediatrics, collaborated on the project with UF colleagues in pharmaceutics, genetics, and materials science a

Contact: Barry Byrne
University of Florida

Page: 1 2 3

Related biology news :

1. Birds eye views earths magnetic lines
2. Researchers find evidence that sea turtles navigate with magnetic maps
3. Controlling biomolecules with magnetic tweezers
4. Exposure to low-level magnetic fields causes DNA damage in rat brain cells, researchers find
5. Combining various magnetic resonance imaging techniques may help improve breast cancer detection
6. In men chronically exposed to magnetic fields, no disruptions of melatonin exists
7. Modern blood vessel measurements test belief that magnetic fields can influence blood flow
8. Researchers suggests a potentially damaging effect of extremely low frequency electromagnetic fields
9. Chemists spin materials to improve magnetic resonance data
10. Analysis of Martian meteorite using unique magnetic microscope
11. Finding the right recipe: Researchers tailor magnetic nanoparticles for medical treatment & diagnosis

Post Your Comments:

(Date:6/23/2017)... N.Y. , June 23, 2017  IBM (NYSE: ... dairy research, today announced a new collaboration using next-generation ... chances that the global milk supply is impacted by ... Cornell University has become the newest academic institution to ... a food safety initiative that includes IBM Research, Mars, ...
(Date:5/16/2017)... , May 16, 2017  Veratad Technologies, LLC ( ... online age and identity verification solutions, announced today they ... Conference 2017, May 15 thru May 17, 2017, in ... and International Trade Center. Identity impacts ... and in today,s quickly evolving digital world, defining identity ...
(Date:4/24/2017)... 2017 Janice Kephart , former ... Strategy Partners, LLP (IdSP) , today issues the ... Trump,s March 6, 2017 Executive Order: Protecting ... can be instilled with greater confidence, enabling the ... refugee applications are suspended by until at least ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... multicenter, prospective clinical study that demonstrates the accuracy of the FebriDx® test, ... clinically significant acute bacterial and viral respiratory tract infections by testing the ...
(Date:10/11/2017)... ... October 11, 2017 , ... The CRISPR-Cas9 ... overexpression experiments and avoiding the use of exogenous expression plasmids. The simplicity of ... performing systematic gain-of-function studies. , This complement to loss-of-function studies, such as ...
(Date:10/11/2017)... LAGUNA HILLS, Calif. , Oct. 11, 2017 /PRNewswire/ ... London (ICR) and University of ... tool to risk-stratify patients with multiple myeloma (MM), in a ... . The University of Leeds is ... Myeloma UK, and ICR will perform the testing services to ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... company advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights that ... Polymerized Liposomal Nanoparticle), a technology developed in collaboration with Children’s Hospital Los ...
Breaking Biology Technology:
Cached News: