HOME >> BIOLOGY >> NEWS
Tiny, magnetic spheres may help overcome gene therapy hurdle

GAINESVILLE, Fla. --- The average person's heart pumps about a gallon of blood per minute, a rate that can easily triple or quadruple during exercise.

The rapid flow of blood through the body is a major roadblock to the use of gene therapy to cure diseases. When injected into the blood, vector viruses which carry corrective genes tend to shoot past the target organ or tissue rather than sticking to it, like grains of sand moving past stones in a fast-flowing river.

Now, University of Florida gene therapy and biomedical engineering researchers have demonstrated a novel approach to the problem. In a July article in Molecular Therapy, they report attaching the adeno-associated virus, a widely used gene carrier, to the surface of tiny manufactured balls known as microspheres, each containing a miniscule particle of iron oxide. Using a magnet placed under culture dishes, the researchers were able to coax large amounts of the microspheres to target areas of the cultures. In related experiments in mice, the researchers showed the microspheres clung to cells or organs longer than the virus alone did.

The procedure, reminiscent of the toy that moves magnetized objects beneath transparent plastic, could someday evolve into a treatment that would enable doctors to guide corrective gene-containing microspheres injected into a patient with magnets placed outside the skin. Such procedures, could, for example, replace invasive catheterizations used to treat lung and heart diseases, the researchers said.

"By packaging the virus with the microsphere, we both guided it to the targeted area and got it to stick there," said Barry Byrne, the lead researcher and a pediatric cardiologist with the UF College of Medicine who is affiliated with the UF Genetics Institute.

Byrne and Cathryn Mah, an assistant research professor in the department of pediatrics, collaborated on the project with UF colleagues in pharmaceutics, genetics, and materials science a
'"/>

Contact: Barry Byrne
bbyrne@ufl.edu
352-846-1531
University of Florida
18-Sep-2002


Page: 1 2 3

Related biology news :

1. Birds eye views earths magnetic lines
2. Researchers find evidence that sea turtles navigate with magnetic maps
3. Controlling biomolecules with magnetic tweezers
4. Exposure to low-level magnetic fields causes DNA damage in rat brain cells, researchers find
5. Combining various magnetic resonance imaging techniques may help improve breast cancer detection
6. In men chronically exposed to magnetic fields, no disruptions of melatonin exists
7. Modern blood vessel measurements test belief that magnetic fields can influence blood flow
8. Researchers suggests a potentially damaging effect of extremely low frequency electromagnetic fields
9. Chemists spin materials to improve magnetic resonance data
10. Analysis of Martian meteorite using unique magnetic microscope
11. Finding the right recipe: Researchers tailor magnetic nanoparticles for medical treatment & diagnosis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/14/2017)... (NYSE: IBM ) is introducing several innovative partner startups ... collaboration between startups and global businesses, taking place in ... nine startups will showcase the solutions they have built with ... France is one of the ... percent increase in the number of startups created between 2012 ...
(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... platform specifically designed for life science researchers to analyze and interpret datasets, ... Franklin, who made a major contribution to the discovery of the double-helix ...
(Date:10/11/2017)... ... ... Personal eye wash is a basic first aid supply for any work environment, but most ... you rinse first if a dangerous substance enters both eyes? It’s one less decision, and ... unique dual eye piece. , “Whether its dirt and debris, or an acid or alkali, ...
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading ... a nationwide oncology Clinical Nurse Educator (CNE) network, which will ... need for communication among health care professionals to enhance the ... nurses, office staff, and other health care professionals to help ... breast cancer. ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... implantation and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... and maternal age to IVF success. , After comparing the results from the ...
Breaking Biology Technology:
Cached News: