HOME >> BIOLOGY >> NEWS
Tiny Molecular Channels Key To Protecting Heart During Attack

Hopkins Finding Could Lead To Development Of Better Cardioprotective Drugs

Researchers at Johns Hopkins have come one step closer to understanding the chain of events that protects the heart against injury during a heart attack, paving the way for the development of a new class of drugs to treat people at risk.

The team has found that tiny, energy-dependent channels within mitochondria -- the sacs of enzymes that act as powerhouses of cells -- may play a significant role during "preconditioning," a process in which brief coronary blood flow stoppages that precede a major heart event protect the heart against severe damage. Mitochondria convert carbohydrate energy into ATP (adenosine triphosphate), the type of energy needed for such functions as muscle contraction.

Using rabbit heart cells, the researchers found that the blood pressure medicine diazoxide opened up channels in the cell membranes that let potassium flow into the cells. The drug opened the potassium channels in the mitochondria but had no effect on other channels. The team also found that when oxygen supply to the heart cells was stopped, as happens during a heart attack, diazoxide halved the rate of cell death.

Results of the study, supported by the National Institutes of Health, were published in the June 30 issue of Circulation: Journal of the American Heart Association. "During periods of ischemia, or lack of blood flow, cells lose energy and die," says Eduardo Marban, M.D., Ph.D., director of molecular and cellular cardiology at Hopkins and senior author of the study. "If we could keep the energy levels high during heart failure or a heart attack, we could buy time. While we're still not sure how opening these mitochondrial channels might protect heart cells from dying, we know that their role is crucial. This will help in developing a more effective class of cardioprotective drugs.

"There is goo
'"/>

Contact: Karen Infeld
kinfeld@jhmi.edu
(410)955-1534
Johns Hopkins Medical Institutions
30-Jun-1998


Page: 1 2

Related biology news :

1. Molecular motor implicated in tissue remodeling
2. 16th EORTC NCI AACR Symposium Molecular Targets and Cancer Therapeutics
3. 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
4. Molecular staples shape a cancer killer
5. Molecular motor myosin VI moves hand over hand, researchers say
6. Molecular therapeutics advance fight against brain cancer
7. Molecular motor shuttles key protein in response to light
8. Molecular traffic cop directs cellular signals
9. Molecular marker predicts success of breast cancer treatment
10. Molecular image of genotoxin reveals how bacteria damage human DNA
11. Molecular mechanism found that may improve ability of stem cells to fight disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2017)... SANTA MONICA, Calif. , April 13, 2017 /PRNewswire/ ... New York will feature emerging and ... Innovation Summits. Both Innovation Summits will run alongside the ... variety of speaker sessions, panels and demonstrations focused on ... east coast,s largest advanced design and manufacturing event will ...
(Date:4/11/2017)... 11, 2017 Research and Markets has announced ... report to their offering. ... global eye tracking market to grow at a CAGR of 30.37% ... Tracking Market 2017-2021, has been prepared based on an in-depth market ... landscape and its growth prospects over the coming years. The report ...
(Date:4/6/2017)... 2017 Forecasts by Product Type ... by End-Use (Transportation & Logistics, Government & Public Sector, ... Fossil Generation Facility, Nuclear Power), Industrial, Retail, Business Organisation ... Are you looking for a definitive report on the ... ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... ... program has won a US2020 STEM Mentoring Award. Representatives of the FirstHand program ... in Volunteer Experience from US2020. , US2020’s mission is to change the trajectory ...
(Date:10/10/2017)... 2017 SomaGenics announced the receipt of a ... RealSeq®-SC (Single Cell), expected to be the first commercially ... microRNAs) from single cells using NGS methods. The NIH,s ... accelerate development of approaches to analyze the heterogeneity of ... techniques for measuring levels of mRNAs in individual cells ...
(Date:10/9/2017)... , Oct. 9, 2017  BioTech Holdings announced ... by which its ProCell stem cell therapy prevents ... ischemia.  The Company, demonstrated that treatment with ProCell ... limbs saved as compared to standard bone marrow ... HGF resulted in reduction of therapeutic effect.  ...
(Date:10/9/2017)... ... October 09, 2017 , ... The Giving Tree Wellness ... targeting the needs of consumers who are incorporating medical marijuana into their wellness ... Arizona. , As operators of two successful Valley dispensaries, The Giving Tree’s two ...
Breaking Biology Technology:
Cached News: