HOME >> BIOLOGY >> NEWS
Tiny Molecular Channels Key To Protecting Heart During Attack

Hopkins Finding Could Lead To Development Of Better Cardioprotective Drugs

Researchers at Johns Hopkins have come one step closer to understanding the chain of events that protects the heart against injury during a heart attack, paving the way for the development of a new class of drugs to treat people at risk.

The team has found that tiny, energy-dependent channels within mitochondria -- the sacs of enzymes that act as powerhouses of cells -- may play a significant role during "preconditioning," a process in which brief coronary blood flow stoppages that precede a major heart event protect the heart against severe damage. Mitochondria convert carbohydrate energy into ATP (adenosine triphosphate), the type of energy needed for such functions as muscle contraction.

Using rabbit heart cells, the researchers found that the blood pressure medicine diazoxide opened up channels in the cell membranes that let potassium flow into the cells. The drug opened the potassium channels in the mitochondria but had no effect on other channels. The team also found that when oxygen supply to the heart cells was stopped, as happens during a heart attack, diazoxide halved the rate of cell death.

Results of the study, supported by the National Institutes of Health, were published in the June 30 issue of Circulation: Journal of the American Heart Association. "During periods of ischemia, or lack of blood flow, cells lose energy and die," says Eduardo Marban, M.D., Ph.D., director of molecular and cellular cardiology at Hopkins and senior author of the study. "If we could keep the energy levels high during heart failure or a heart attack, we could buy time. While we're still not sure how opening these mitochondrial channels might protect heart cells from dying, we know that their role is crucial. This will help in developing a more effective class of cardioprotective drugs.

"There is goo
'"/>

Contact: Karen Infeld
kinfeld@jhmi.edu
(410)955-1534
Johns Hopkins Medical Institutions
30-Jun-1998


Page: 1 2

Related biology news :

1. Molecular motor implicated in tissue remodeling
2. 16th EORTC NCI AACR Symposium Molecular Targets and Cancer Therapeutics
3. 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
4. Molecular staples shape a cancer killer
5. Molecular motor myosin VI moves hand over hand, researchers say
6. Molecular therapeutics advance fight against brain cancer
7. Molecular motor shuttles key protein in response to light
8. Molecular traffic cop directs cellular signals
9. Molecular marker predicts success of breast cancer treatment
10. Molecular image of genotoxin reveals how bacteria damage human DNA
11. Molecular mechanism found that may improve ability of stem cells to fight disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/22/2017)... 21, 2017   Neurotechnology , a provider ... today announced the release of the SentiVeillance ... improved facial recognition using up to 10 surveillance, ... computer. The new version uses deep neural-network-based facial ... it utilizes a Graphing Processing Unit (GPU) for ...
(Date:3/22/2017)... March 21, 2017 Vigilant Solutions , ... law enforcement agencies, announced today the appointment of retired ... of public safety business development. Mr. Sheridan ... experience, including a focus on the aviation transportation sector, ... recent position, Mr. Sheridan served as the Aviation Liaison ...
(Date:3/20/2017)... Pa. , March 20, 2017 PMD ... 2.0 personal spirometer and Wellness Management System (WMS), a ... Founded in 2010, PMD Healthcare is a Medical ... with a mission dedicated to creating innovative solutions that ... life. With that intent focus, PMD developed the first ...
Breaking Biology News(10 mins):
(Date:5/16/2017)... ... 16, 2017 , ... Zansors has secured a patent ... or EKG) acquisition and monitoring device. This Zansors’ next-generation intellectual property (IP), will ... the skin, making them significantly easier to deploy and use. , Currently, ECG ...
(Date:5/15/2017)... ... May 15, 2017 , ... Tunnell Consulting announced that ... “The Key Role of Specifications in Process Validation,” at the Process Validation Summit ... will bring together leaders from the pharmaceutical and biotech industries to explore processes, strategies ...
(Date:5/12/2017)... , May 12, 2017 GreenMark Biomedical Inc. ... at the 36th annual Michigan Growth Capital Symposium (MGCS) ... Delaware corporation with facilities in ... investors in attendance, including more than 100 top venture ... to society through biobased targeting technologies. GreenMark ...
(Date:5/11/2017)... ... ... The key to unlocking the cause of Multiple Sclerosis may lie in ... that can rob people of their ability to see, speak, and walk. It is ... a genetic tendency towards the disease combined with an unidentified environmental trigger. The genetics ...
Breaking Biology Technology:
Cached News: