HOME >> BIOLOGY >> NEWS
Tiny molecules have big potential as cancer drugs, Stanford researcher believes

PHILADELPHIA Many cancer therapies take a "big stick" approach, targeting rapidly dividing cells in the body to stop malignancies in their tracks but often triggering horrible side effects in the process. New research from the Stanford University School of Medicine points toward the possibility of a different type of cancer drug small molecules that would home in on the proteins tumors need without poisoning patients.

Matthew Bogyo, PhD, assistant professor of pathology, will discuss his studies of some of these molecules at an Aug. 24 talk during the "Genomic Approaches to Enzymology" session of the American Chemical Society's national meeting in Philadelphia.

Previous studies have shown that an increase of certain proteins, called cathepsin cysteine proteases, is associated with tumor development. "People have shown that more of the cathepsins are present in cancers and that they appear to be secreted by cancer cells," said Bogyo. "The question is what are they doing and does it help to block them?" To find out, Bogyo and colleagues used fluorescent tags to track cathepsin activity in mouse models of two types of cancer. They found the cathepsins helped build blood vessels to the tumors as well as increase tumor growth and invasiveness.

The team also tried giving a broad-spectrum cathepsin inhibitor to some cancerous mice and found that it slowed tumor development both in early and late stages of growth with no apparent side effects. The National Cancer Institute has since fast-tracked the inhibitor into studies of toxicity and pharmacodynamics as a potential drug. Meanwhile the research group has used the compound as a jumping-off point, testing similar compounds to find those that bind specifically to "problem" cathepsins, instead of to all of them. Bogyo is also looking for additional molecules that have better potency and pharmacodynamic properties.

Bogyo will give details on tests of some of these molecules at his presentatio
'"/>

Contact: Mitzi Baker
mitzibaker@stanford.edu
650-725-2106
Stanford University Medical Center
24-Aug-2004


Page: 1 2

Related biology news :

1. Synthesized molecules studied as weapon to stop cell division in cancer cells
2. Scientists reinvent DNA as template to produce organic molecules
3. Sweet success in targeting sugar molecules to cells in living animals
4. UC Riverside researcher takes snapshots of the movement of molecules in a billionth of a second
5. Scientists pinpoint molecules that generate synapses
6. Two molecules work together to aid transport of immune cells, UT Southwestern researchers find
7. Controlling biomolecules with magnetic tweezers
8. Water molecules clump more loosely than previously thought
9. Creating polymers that act like biomolecules
10. A new way to see DNA (and other tiny molecules)
11. St. Jude shows how disorderliness in some proteins lets them interact with a diversity of molecules

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/17/2019)... ... July 18, 2019 , ... Flagship Biosciences, the advanced ... to its executive team as Vice President of Operations. Ms. James brings a ... new role, Ms. James is responsible for ensuring on-time delivery of all projects ...
(Date:7/17/2019)... ... July 17, 2019 , ... ... acclaimed pediatric urologists are among the professionals honored in U.S. News & ... among the country’s pediatric healthcare landscape. , Georgia Urology’s wholly-owned subsidiary, ...
(Date:7/17/2019)... ... 15, 2019 , ... RCH Solutions (RCH), a ... companies, announces the availability of new specialty advisory practice, a Public Cloud Managed ... emerging bio-pharma companies interested in achieving specific outcomes related to public Cloud adoption. ...
Breaking Biology News(10 mins):
(Date:6/11/2019)... ... June 11, 2019 , ... Mytonomy, the leader ... leader in opioid treatment, announced today they are partnering to combat the opioid ... deployed its virtual care platform at the Mayo Clinic to drive shared decision ...
(Date:6/11/2019)... ... June 11, 2019 , ... A study released today in ... are able to incorporate into human CD34+ cells, modifying their gene expression and ... increased the cells’ ability to lodge into bone marrow. This research performed by ...
(Date:5/31/2019)... ... 29, 2019 , ... For many years, the primary forms of cancer treatment ... therapies. Advances in immuno-oncology have led to the advent of Chimeric Antigen Receptor T ... cell receptors known as “CARs”. The CAR enables the final product to produce chemicals ...
(Date:5/31/2019)... , ... May 30, 2019 , ... ... thinking on Data Integrity on July 08-09, 2019 in Boston, MA. This peer ... and medical device organizations. , The training will kick off with a compendial ...
Breaking Biology Technology:
Cached News: