HOME >> BIOLOGY >> NEWS
Tiny molecules have big potential as cancer drugs, Stanford researcher believes

PHILADELPHIA Many cancer therapies take a "big stick" approach, targeting rapidly dividing cells in the body to stop malignancies in their tracks but often triggering horrible side effects in the process. New research from the Stanford University School of Medicine points toward the possibility of a different type of cancer drug small molecules that would home in on the proteins tumors need without poisoning patients.

Matthew Bogyo, PhD, assistant professor of pathology, will discuss his studies of some of these molecules at an Aug. 24 talk during the "Genomic Approaches to Enzymology" session of the American Chemical Society's national meeting in Philadelphia.

Previous studies have shown that an increase of certain proteins, called cathepsin cysteine proteases, is associated with tumor development. "People have shown that more of the cathepsins are present in cancers and that they appear to be secreted by cancer cells," said Bogyo. "The question is what are they doing and does it help to block them?" To find out, Bogyo and colleagues used fluorescent tags to track cathepsin activity in mouse models of two types of cancer. They found the cathepsins helped build blood vessels to the tumors as well as increase tumor growth and invasiveness.

The team also tried giving a broad-spectrum cathepsin inhibitor to some cancerous mice and found that it slowed tumor development both in early and late stages of growth with no apparent side effects. The National Cancer Institute has since fast-tracked the inhibitor into studies of toxicity and pharmacodynamics as a potential drug. Meanwhile the research group has used the compound as a jumping-off point, testing similar compounds to find those that bind specifically to "problem" cathepsins, instead of to all of them. Bogyo is also looking for additional molecules that have better potency and pharmacodynamic properties.

Bogyo will give details on tests of some of these molecules at his presentatio
'"/>

Contact: Mitzi Baker
mitzibaker@stanford.edu
650-725-2106
Stanford University Medical Center
24-Aug-2004


Page: 1 2

Related biology news :

1. Synthesized molecules studied as weapon to stop cell division in cancer cells
2. Scientists reinvent DNA as template to produce organic molecules
3. Sweet success in targeting sugar molecules to cells in living animals
4. UC Riverside researcher takes snapshots of the movement of molecules in a billionth of a second
5. Scientists pinpoint molecules that generate synapses
6. Two molecules work together to aid transport of immune cells, UT Southwestern researchers find
7. Controlling biomolecules with magnetic tweezers
8. Water molecules clump more loosely than previously thought
9. Creating polymers that act like biomolecules
10. A new way to see DNA (and other tiny molecules)
11. St. Jude shows how disorderliness in some proteins lets them interact with a diversity of molecules

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/22/2020)... (PRWEB) , ... January 21, 2020 , ... ... Pozil to lead the company’s new Business Development Department. The move, which is ... Pozil had been previously serving as the company’s Senior Vice President where he ...
(Date:1/22/2020)... ... January 21, 2020 , ... ... transport validation strategies, supporting global regulatory applications, and executing global clinical trial ... Business Journal as a fastest growing company, and ISO 9001:2015 certification with ...
(Date:1/8/2020)... , ... January 08, 2020 , ... ... now offering complimentary overnight shipping to its nationwide practice network partners. Not ... also due to volume in its Network the biologics themselves are less expensive. ...
Breaking Biology News(10 mins):
(Date:1/24/2020)... RIDING, Va. (PRWEB) , ... January 24, 2020 ... ... and other innovations created by companies in biotechnology, diagnostics, therapeutics, laboratory and clinical ... lives of millions of people around the world. And as Slone Partners ...
(Date:1/22/2020)... ... January 21, 2020 , ... ... Taylor as Southern Midwest Region Industrial and Institutional (I&I) Account Manager. Darrell will ... , Darrell brings over 30 years of sales experience working across ...
(Date:1/10/2020)... ... January 09, 2020 , ... Phlexglobal, the leading provider ... of Cunesoft, a move that expands the company’s portfolio of best-of-breed technologies designed ... , Based in Munich, Germany, Cunesoft provides intelligent software and expert services for ...
(Date:1/7/2020)... ... January 07, 2020 , ... Absolute Antibody Ltd. , ... of its VivopureX™ recombinant mouse antibodies for in vivo research in mouse models. ... hamsters, which Absolute Antibody has engineered into mouse-anti-mouse recombinant versions to improve research ...
Breaking Biology Technology:
Cached News: