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d may be involved in the pathogenesis of chronic liver diseases in humans," say the researchers.

(O. Ananieva, I. Nilsson, T. Vorobjova, R. Uibo and T. Wadstrom. 2002. Immune responses to bile-tolerant Helicobacter species in patients with chronic liver diseases, a randomized population group, and healthy blood donors. Clinical and Diagnostic Laboratory Immunology, 9: 1160-1164.)

Existing antiviral potential treatment for smallpox

A drug currently licensed for treatment of an opportunistic infection in AIDS patients may be an effective treatment against smallpox, say researchers from the Rega Institute for Medical Research in Belgium and the Academy of Sciences of the Czech Republic. Their findings appear in the November 2002 issue of the journal Antimicrobial Agents and Chemotherapy.

In the study, the researchers tested the effectiveness of a variety of drugs on their ability to prevent replication of vaccinia virus, a distant relative of smallpox that is used in the current smallpox vaccine. One antiviral drug, cidofovir, that has already been approved for other treatments, appeared to be highly active against poxvirus infection.

"Cidofovir, which is on the market for treatment of human cytomegalovirus retinitis in immunocompromised patients, is potentially a good candidate for the treatment of a poxvirus outbreak, in the absence of any vaccination," say the researchers.

(R. Snoeck, A. Holy, C. Dewolf-peeters, J. Van Den Oord, E. De Clercq, and G. Andrei. 2002. Antivaccinia activities of acyclic nucleoside phosphonate derivatives in epithelial cells and organotypic cultures. Antimicrobial Agents and Chemotherapy, 46: 3356-3361.)


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Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
11-Nov-2002


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