HOME >> BIOLOGY >> NEWS
Tissue cells can revert to stem cells

Baltimore, MD. Scientists at the Carnegie Institution in Baltimore, MD, have found that certain cells involved in egg development in the fruitfly can be stimulated to revert to fully functioning stem cells. "This finding could lead to new sources of stem cells from other tissues and other animals," commented Dr. Allan Spradling, director of the Carnegie department and co-author of the study published in the March 14 online issue of Nature.

The research conducted by Spradling--a Howard Hughes Medical Institute Investigator-- and colleague Dr. Toshie Kai, involved so-called germline stem cells of the female fruitfly. These cells are precursors to eggs and begin their journey as stem cells living in a special environment called a niche. In the niche, a stem cell splits into two daughter cells, one of which leaves the niche to begin its transformation. Through a series of 4 divisions a cluster of 16 cells forms--an immature egg with 15 accompanying nurse cells. The researchers discovered that the cells in clusters of 4 and 8 cells can still return to the stem-cell state under appropriate conditions. Moreover, the reverted stem cells worked as well as normal stem cells. Flies with only reverted stem cells were as fertile as normal flies throughout adult life.

"For most stem cells, it has not been possible yet to determine how quickly their progeny cells lose the ability to function again as stem cells," Spradling noted. "In the fruitfly (Drosophila) ovary we could directly test this and found conditions where the cluster cells reverted to a stem-cell state and functioned throughout the entire life of the adult. We don't know yet if this will be a general result that applies to other stem cells," cautioned Kai. "The progeny of germline stem cells might develop relatively slowly compared with other stem cell progeny, and thus retain their 'stemness' longer."

The scientists made their discovery by placing the cell clusters
'"/>

Contact: Dr. Allan Spradling
spradling@ciwemb.edu
410-554-1201
Carnegie Institution
14-Mar-2004


Page: 1 2

Related biology news :

1. Tissue-engineered bone speeds healing in laboratory tests
2. Tissue engineering for erectile dysfunction?
3. Tissue proteolysis and male infertility
4. University of Washington partners with Advanced Tissue Sciences and others in $10 million grant to grow human heart tissue
5. Fullerene-Based Materials Clear From Tissue, Go To The Bone
6. Wistar Scientists Locate Genes Involved In Mammalian Tissue Regeneration
7. Body Building: Tissue Engineered Organs A Heartbeat Away
8. Ligand Scientists Discover Tissue-Selective Female Hormone Mimics
9. Newly Recognized Cell-Surface Receptor Protects Heart Tissue Against Damage
10. Hard Hearts: New Discovery Of Bone In Heart Tissue May Explain Valve Disease
11. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Tissue cells can revert stem cells

(Date:3/23/2015)... , March 23, 2015 SoundView Technology Group issues ... (NASDAQ: NXTD ) Wocket smart wallet. SoundView was one of ... on their experience with the Wocket in multiple scenarios and ... Whole Foods and other retailers, making both debit and credit ... also says, "If the company meets their plans in ...
(Date:3/20/2015)... and Markets ( http://www.researchandmarkets.com/research/rswjb4/hand_geometry ) has announced the ... Report" report to their offering. This report ... The report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... Annual estimates and forecasts are provided for the period ...
(Date:3/17/2015)... Minn. , March 17, 2015 ... technology company specializing in clinical study management systems, ... be in attendance at ARENA,s Outsourcing in Clinical ... NC.  This event provides an excellent forum for ... easy-to-use, flexible and affordable software-as-a-service (SaaS) eClinical technology ...
Breaking Biology News(10 mins):Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4Connect With MedNet Solutions At Outsourcing In Clinical Trials Southeast 2
(Date:3/31/2015)... YARDLEY, Pa. , March 31, 2015 /PRNewswire/ ... capabilities by integrating Mapi,s Medical Affairs and global ... Pharmacovigilance from a previously announced acquisition . ... operations are conducted by a global team ... professionals that have decades of experience in navigating ...
(Date:3/31/2015)... March 31, 2015 Today, Cryos International, ... relocation of their U.S. facilities and inventory from New ... years of experience, Cryos’ relocation is a reflection of ... move to Orlando was completed during the first weekend ... opening taking place on April 6. The new facility ...
(Date:3/30/2015)... , March 30, 2015  Multiple new research abstracts ... several important health factors. From their impact on colon ... positive effect on both gut health and vascular health, ... detail our latest understanding of walnuts, inner workings. Running ... , this annual meeting attracts an international audience ...
(Date:3/30/2015)... Md. , March 30, 2015 CASI ... dedicated to the acquisition, development and commercialization of innovative ... the global market with a commercial focus on ... Food and Drug Administration (CFDA) has approved the Company,s ... in ovarian clear cell carcinoma (OCCC) patients for its ...
Breaking Biology Technology:Mapi expands Pharmacovigilance and Risk Management capabilities 2Mapi expands Pharmacovigilance and Risk Management capabilities 3Cryos International Completes Groundbreaking Sperm Migration to Orlando, Florida 2New Findings Support the Benefits of Eating Walnuts on Overall Health 2New Findings Support the Benefits of Eating Walnuts on Overall Health 3New Findings Support the Benefits of Eating Walnuts on Overall Health 4CASI Pharmaceuticals Receives Approval From CFDA For Phase 2 Clinical Trial In China With ENMD-2076 For Ovarian Clear Cell Carcinoma 2CASI Pharmaceuticals Receives Approval From CFDA For Phase 2 Clinical Trial In China With ENMD-2076 For Ovarian Clear Cell Carcinoma 3CASI Pharmaceuticals Receives Approval From CFDA For Phase 2 Clinical Trial In China With ENMD-2076 For Ovarian Clear Cell Carcinoma 4CASI Pharmaceuticals Receives Approval From CFDA For Phase 2 Clinical Trial In China With ENMD-2076 For Ovarian Clear Cell Carcinoma 5
Cached News: