HOME >> BIOLOGY >> NEWS
Tissue cells can revert to stem cells

Baltimore, MD. Scientists at the Carnegie Institution in Baltimore, MD, have found that certain cells involved in egg development in the fruitfly can be stimulated to revert to fully functioning stem cells. "This finding could lead to new sources of stem cells from other tissues and other animals," commented Dr. Allan Spradling, director of the Carnegie department and co-author of the study published in the March 14 online issue of Nature.

The research conducted by Spradling--a Howard Hughes Medical Institute Investigator-- and colleague Dr. Toshie Kai, involved so-called germline stem cells of the female fruitfly. These cells are precursors to eggs and begin their journey as stem cells living in a special environment called a niche. In the niche, a stem cell splits into two daughter cells, one of which leaves the niche to begin its transformation. Through a series of 4 divisions a cluster of 16 cells forms--an immature egg with 15 accompanying nurse cells. The researchers discovered that the cells in clusters of 4 and 8 cells can still return to the stem-cell state under appropriate conditions. Moreover, the reverted stem cells worked as well as normal stem cells. Flies with only reverted stem cells were as fertile as normal flies throughout adult life.

"For most stem cells, it has not been possible yet to determine how quickly their progeny cells lose the ability to function again as stem cells," Spradling noted. "In the fruitfly (Drosophila) ovary we could directly test this and found conditions where the cluster cells reverted to a stem-cell state and functioned throughout the entire life of the adult. We don't know yet if this will be a general result that applies to other stem cells," cautioned Kai. "The progeny of germline stem cells might develop relatively slowly compared with other stem cell progeny, and thus retain their 'stemness' longer."

The scientists made their discovery by placing the cell clusters
'"/>

Contact: Dr. Allan Spradling
spradling@ciwemb.edu
410-554-1201
Carnegie Institution
14-Mar-2004


Page: 1 2

Related biology news :

1. Tissue-engineered bone speeds healing in laboratory tests
2. Tissue engineering for erectile dysfunction?
3. Tissue proteolysis and male infertility
4. University of Washington partners with Advanced Tissue Sciences and others in $10 million grant to grow human heart tissue
5. Fullerene-Based Materials Clear From Tissue, Go To The Bone
6. Wistar Scientists Locate Genes Involved In Mammalian Tissue Regeneration
7. Body Building: Tissue Engineered Organs A Heartbeat Away
8. Ligand Scientists Discover Tissue-Selective Female Hormone Mimics
9. Newly Recognized Cell-Surface Receptor Protects Heart Tissue Against Damage
10. Hard Hearts: New Discovery Of Bone In Heart Tissue May Explain Valve Disease
11. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/22/2016)... PROVO and SANDY, Utah ... (NSO), which operates the highest sample volume laboratory in ... Tute Genomics and UNIConnect, leaders in clinical sequencing informatics ... the launch of a project to establish the informatics ... NSO has been contracted by the ...
(Date:3/18/2016)... 18, 2016 --> ... ICT, Manned & Unmanned Vehicles, Physical infrastructure and Perimeter Surveillance ... in the border security market and the continuing migration crisis ... Europe has led visiongain to publish this ... --> defence & security companies in the ...
(Date:3/15/2016)... ALBANY, New York , March 15, 2016 ... a new market report published by Transparency Market Research "Digital ... Growth, Trends and Forecast 2015 - 2023," the global digital ... at US$ 731.9 Mn in 2014 and is forecast to ... to 2023. Growth of micro, small and medium enterprises (MSMEs) ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... ... May 25, 2016 , ... Founder of ... board-certified in surgery and surgery of the hand by the National Board of ... to going above and beyond in his pursuit of providing the most comprehensive, ...
(Date:5/25/2016)... ... May 25, 2016 , ... WEDI, the nation’s leading authority on ... that Charles W. Stellar has been named by the WEDI Board of Directors as ... As an executive leader with more than 35 years of experience in healthcare, association ...
(Date:5/24/2016)... ... May 24, 2016 , ... ... traumatic injuries, will be accelerated by research at Worcester Polytechnic Institute (WPI) that ... wound healing and tissue regeneration. , The novel method, developed by WPI faculty ...
(Date:5/24/2016)... Maryland (PRWEB) , ... May 24, 2016 , ... ... of a newly re-branded identity. The new Media Cybernetics corporate branding reflects a ... world of imaging and image analysis. The re-branding components include a crisp, refreshed ...
Breaking Biology Technology:
Cached News: