HOME >> BIOLOGY >> NEWS
Tissue cells can revert to stem cells

Baltimore, MD. Scientists at the Carnegie Institution in Baltimore, MD, have found that certain cells involved in egg development in the fruitfly can be stimulated to revert to fully functioning stem cells. "This finding could lead to new sources of stem cells from other tissues and other animals," commented Dr. Allan Spradling, director of the Carnegie department and co-author of the study published in the March 14 online issue of Nature.

The research conducted by Spradling--a Howard Hughes Medical Institute Investigator-- and colleague Dr. Toshie Kai, involved so-called germline stem cells of the female fruitfly. These cells are precursors to eggs and begin their journey as stem cells living in a special environment called a niche. In the niche, a stem cell splits into two daughter cells, one of which leaves the niche to begin its transformation. Through a series of 4 divisions a cluster of 16 cells forms--an immature egg with 15 accompanying nurse cells. The researchers discovered that the cells in clusters of 4 and 8 cells can still return to the stem-cell state under appropriate conditions. Moreover, the reverted stem cells worked as well as normal stem cells. Flies with only reverted stem cells were as fertile as normal flies throughout adult life.

"For most stem cells, it has not been possible yet to determine how quickly their progeny cells lose the ability to function again as stem cells," Spradling noted. "In the fruitfly (Drosophila) ovary we could directly test this and found conditions where the cluster cells reverted to a stem-cell state and functioned throughout the entire life of the adult. We don't know yet if this will be a general result that applies to other stem cells," cautioned Kai. "The progeny of germline stem cells might develop relatively slowly compared with other stem cell progeny, and thus retain their 'stemness' longer."

The scientists made their discovery by placing the cell clusters
'"/>

Contact: Dr. Allan Spradling
spradling@ciwemb.edu
410-554-1201
Carnegie Institution
14-Mar-2004


Page: 1 2

Related biology news :

1. Tissue-engineered bone speeds healing in laboratory tests
2. Tissue engineering for erectile dysfunction?
3. Tissue proteolysis and male infertility
4. University of Washington partners with Advanced Tissue Sciences and others in $10 million grant to grow human heart tissue
5. Fullerene-Based Materials Clear From Tissue, Go To The Bone
6. Wistar Scientists Locate Genes Involved In Mammalian Tissue Regeneration
7. Body Building: Tissue Engineered Organs A Heartbeat Away
8. Ligand Scientists Discover Tissue-Selective Female Hormone Mimics
9. Newly Recognized Cell-Surface Receptor Protects Heart Tissue Against Damage
10. Hard Hearts: New Discovery Of Bone In Heart Tissue May Explain Valve Disease
11. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Tissue cells can revert stem cells

(Date:7/25/2014)... a molecular testing panel developed at UPMC greatly ... surgery for patients with thyroid nodules and cancer, ... Institute (UPCI), partner with UPMC CancerCenter., The test, ... other diagnostic testing agencies, improved the chances of ... percent, according to the study published this month ...
(Date:7/24/2014)... July 24, 2014 -- Keryx Biopharmaceuticals, Inc. (Nasdaq:KERX) (the ... randomized, active control Phase 3 study of Zerenex (ferric ... for the treatment of hyperphosphatemia in patients with end-stage ... binding and iRon delivery with FErric CiTrate in EsrD) ... the American Society of Nephrology ( JASN ). ...
(Date:7/24/2014)... on different species of fish, according to a ... Exeter which tested fish anti-predator behaviour. , ... predator model when exposed to additional noise, whereas ... , Lead author Dr Irene Voellmy of Bristol,s ... many aquatic environments have increased substantially during the ...
Breaking Biology News(10 mins):Test increases odds of correct surgery for thyroid cancer patients 2Test increases odds of correct surgery for thyroid cancer patients 3Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 2Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 3Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 4
(Date:7/24/2014)... most natural and synthetic processes prefer to settle ... or energyit is within the realm of non-equilibrium ... constant changes in energy and phases, such as ... conditions allow humans to regulate their body temperature, ... with seismic activity. , But even though ...
(Date:7/24/2014)... July 24, 2014 Your cell ... in modeling lithium-ion battery storage capacity. , New ... a theoretical model created at Lawrence Livermore ... that predicts how carbon components will perform as ... emphasizes the urgent need for higher-performance batteries. Several ...
(Date:7/24/2014)... July 24, 2014 Three companies from ... in Livestrong’s Big C Competition. Out of 700 competition ... headed to the semi-final round. In this round twenty ... accelerator program, complete with mentoring from thought-leaders and medical ... part of the angelMD commitment to the Livestrong vision ...
(Date:7/24/2014)... N.J. , July 24, 2014 ... provider of regulatory and ethical review services for ... Alliance Biosciences. Formerly a division of ... was the leading biosafety and biosecurity consulting firm ... With this addition, WCG,s biosafety division – WCG ...
Breaking Biology Technology:New approach to form non-equilibrium structures 2Getting More Life out of Lithium-ion Batteries 23 angelMD Startups Make Livestrong Big C Semi-finals 2WIRB-Copernicus Group Announces Acquisition of Alliance Biosciences; Executives Join WCG Biosafety Division 2WIRB-Copernicus Group Announces Acquisition of Alliance Biosciences; Executives Join WCG Biosafety Division 3
Cached News: