Topical vaccine protects against inhaled ricin

BALTIMORE, MD March 8, 2004 -- An experimental vaccine that can be applied directly to the skin or via a patch protects mice from lethal exposure to aerosolized ricin. Researchers present their findings today at the American Society for Microbiology's (ASM) Biodefense Research Meeting.

"No vaccine or specific therapy is currently available for ricin poisoning," says Gary Matyas of the Walter Reed Army Institute of Research, a presenter on the study which also included scientists from the United States Army Research Medical Institute of Infectious Diseases and Iomai Corporation.

In the study, the researchers incorporated a harmless fragment of the ricin molecule (RTA 1-33/44-198) into a transcutaneous immunization (TCI) formulation. TCI is a needle-free alternative for vaccination in which the antigen is mixed with adjuvant and applied directly to the skin or on a patch that is applied to the skin. The vaccine was then applied either directly to the skin of mice or incorporated into a patch. After several weeks all the mice showed high levels of anti-ricin immune responses. All the mice that had received the direct application survived a lethal challenge of inhaled ricin and 70% of those that received the vaccine via the patch survived.

"Transcutaneous immunization with RTA 1-33/44-198 offers a viable alternative delivery route for this promising recombinant ricin vaccine candidate," says Matyas.


Contact: Jim Sliwa
American Society for Microbiology

Page: 1

Related biology news :

1. Topical oxygen helps hard-to-heal wounds heal faster and better
2. Topical Agent Found To Kill Papillomavirus
3. Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
4. Pneumococcal vaccine reduces ear infections, pneumonia, new study shows
5. UC Irvine scientists to develop vaccine to combat bioterrorism threat from deadly bacteria
6. First clinical study of new pediatric croup vaccine shows safety, tolerability in adults
7. Protective gene may enhance vaccine responses
8. Protein vaccine fully protects mice from lethal aerosol challenge with ricin toxin
9. New glycan arrays discover autoimmunogenic activities of SARS-CoV: concern over monkey vaccine
10. Growing new breed of vaccine-producing plants to fight human diseases worldwide
11. Childrens Hospital Boston receives more than $10 million to help make smallpox vaccine safer

Post Your Comments:

(Date:6/11/2019)... ... June 10, 2019 , ... Improved Pharma LLC announces the ... issue of AAPS PharmSciTech. The article was published online on April 29th, 2019. The ... along with Xiaoming Sean Chen of Purdue University. , The article is the most ...
(Date:6/6/2019)... , ... June 05, 2019 , ... ... the opening of a new network station and service center in Mexico City, ... 12th in the world — with more than $1.75 billion in pharmaceutical exports ...
(Date:6/4/2019)... (PRWEB) , ... June 04, 2019 , ... ... manufacturing of orthopedic medical devices, today announced Q1-19 revenues of $31M, up 12% ... combined with successful roll-out of strategic investments & operational excellence initiatives worldwide. , ...
Breaking Biology News(10 mins):
(Date:5/4/2019)... ... May 03, 2019 , ... More than three ... Pesquisas Association, the scientist and ufologist Urandir Fernandes de Oliveira, last Thursday (25), ... the results of some research carried out by the association, in partnership with ...
(Date:5/2/2019)... TORONTO (PRWEB) , ... May 02, 2019 , ... Stay ... pharma, biotech, medical device and food industries. Access to all webinars is free, so ... stay relevant in your field! , Visit http://www.xtalks.com to see our upcoming ...
(Date:4/25/2019)... , ... April 24, 2019 , ... ... Agents for sales and service organizations, today announced global availability of Inference ... providers and enterprises of all sizes to harness the power of Google’s ...
(Date:4/15/2019)... ... April 15, 2019 , ... Sirrus, Inc., a developer of ... plant expansion to increase production of methylene malonate monomers and oligomers. , The ... Sirrus’ full-scale production facility, which is scheduled to break ground in 2019. “The ...
Breaking Biology Technology:
Cached News: