HOME >> BIOLOGY >> NEWS
Toxic Protein That Interferes With Brain Signals May Trigger Onset Of,,Alzheimer's Disease

CHICAGO --- Researchers have discovered new, highly toxic proteins that disrupt brain mechanisms for learning and memory and which may set off the progression of Alzheimer's disease.

The globular-shaped proteins, called amyloid beta-derived diffusible ligands (or ADDLs), were identified by a team of neuroscientists at Northwestern University, Evanston Northwestern Healthcare and the University of Southern California, Los Angeles.

A report on the group's findings appears in the May 26 issue of the Proceedings of the National Academy of Sciences.

ADDLs are a surprising new form of the amyloid beta protein. Amyloid beta has been known for years to accumulate as enormous fibers in Alzheimer's afflicted brains. A long-standing hypothesis has been that these fibers attack nerve cells and cause Alzheimer's dementia. These scientists now have found that ADDLs, which are minuscule clumps of amyloid beta only a tiny fraction the size of a fiber, may be more relevant to the disease process.

Their experiments in laboratory specimens found that, even at highly dilute concentrations, ADDLs interfere with long-term potentiation, one of the nerve cell processes that is essential to learning and memory. This dysfunction occurred well in advance of the cellular degeneration considered by many researchers to be the cause of Alzheimer's disease. Cell death, when it did occur, was most evident in the hippocampus, the brain's "storage bin" for short-term memory, said William L. Klein, senior author on this study. Klein is a professor of neurobiology and physiology and of neurology at Northwestern.

"Our work suggests that corruption of such signaling by ADDLs may account for the loss of synaptic memory formation at the early stages of Alzheimer's disease and for the nerve cell death and profound dementia at end stages of the disease," he said.

ADDLs apparently form when certain inflammatory proteins are present
'"/>

Contact: Elizabeth Crown
e-crown@nwu.edu
312-503-8928
Northwestern University
25-May-1998


Page: 1 2 3

Related biology news :

1. NIEHS/NTP Director Dr. Kenneth Olden receives Society of Toxicologys Public Communications Award
2. Toxic protein could explain Alzheimers and lead to breakthroughs
3. Toxicogenomics provides insight on assigning breast cancer drugs
4. Toxic compound opens potentially important cell gates
5. Toxicologists discover traces of diesel exhaust in the body
6. National Toxicology Program (NTP) public meeting on the report on carcinogens
7. Pollutants Found In House Dust Increase Pesticides Toxicity
8. Mixing Radiation, Minerals, Toxic Waste Could Be Cleanup Boon -- Or Kaboom
9. Toxicologists To Meet March 14-18 In New Orleans
10. Duke Study Finds More Genes May Be Affected By Toxic Cadmium
11. Flexibility In Cutting Toxic Releases Yields Dividends

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... -- NXT-ID, Inc. (NASDAQ:   NXTD ) ("NXT-ID" ... of independent Directors Mr. Robin D. Richards and ... furthering the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive Officer ... guidance and benefiting from their considerable expertise as we move ...
(Date:4/5/2017)... KEY FINDINGS The global market for stem ... 25.76% during the forecast period of 2017-2025. The rise ... growth of the stem cell market. Download ... The global stem cell market is segmented on the ... cell market of the product is segmented into adult ...
(Date:3/30/2017)... 2017 The research team of The Hong ... fingerprint identification by adopting ground breaking 3D fingerprint minutiae recovery and ... speed and accuracy for use in identification, crime investigation, immigration control, ... ... A research team led ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... with the addition of its newest module, US Hemostats & Sealants. , SmartTRAK’s ... hemostats, absorbable hemostats, fibrin sealants, synthetic sealants and biologic sealants used in surgical ...
(Date:10/11/2017)... ... October 11, 2017 , ... Personal eye wash is a basic first aid supply for any ... So which eye do you rinse first if a dangerous substance enters both eyes? It’s ... Wash with its unique dual eye piece. , “Whether its dirt and debris, or ...
(Date:10/11/2017)... (PRWEB) , ... October 11, 2017 , ... Disappearing forests ... the lives of over 5.5 million people each year. Especially those living in larger ... startup Treepex - based in one of the most pollution-affected countries globally - decided ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... program has won a US2020 STEM Mentoring Award. Representatives of the FirstHand program ... in Volunteer Experience from US2020. , US2020’s mission is to change the trajectory ...
Breaking Biology Technology:
Cached News: