HOME >> BIOLOGY >> NEWS
Toxic Protein That Interferes With Brain Signals May Trigger Onset Of,,Alzheimer's Disease

CHICAGO --- Researchers have discovered new, highly toxic proteins that disrupt brain mechanisms for learning and memory and which may set off the progression of Alzheimer's disease.

The globular-shaped proteins, called amyloid beta-derived diffusible ligands (or ADDLs), were identified by a team of neuroscientists at Northwestern University, Evanston Northwestern Healthcare and the University of Southern California, Los Angeles.

A report on the group's findings appears in the May 26 issue of the Proceedings of the National Academy of Sciences.

ADDLs are a surprising new form of the amyloid beta protein. Amyloid beta has been known for years to accumulate as enormous fibers in Alzheimer's afflicted brains. A long-standing hypothesis has been that these fibers attack nerve cells and cause Alzheimer's dementia. These scientists now have found that ADDLs, which are minuscule clumps of amyloid beta only a tiny fraction the size of a fiber, may be more relevant to the disease process.

Their experiments in laboratory specimens found that, even at highly dilute concentrations, ADDLs interfere with long-term potentiation, one of the nerve cell processes that is essential to learning and memory. This dysfunction occurred well in advance of the cellular degeneration considered by many researchers to be the cause of Alzheimer's disease. Cell death, when it did occur, was most evident in the hippocampus, the brain's "storage bin" for short-term memory, said William L. Klein, senior author on this study. Klein is a professor of neurobiology and physiology and of neurology at Northwestern.

"Our work suggests that corruption of such signaling by ADDLs may account for the loss of synaptic memory formation at the early stages of Alzheimer's disease and for the nerve cell death and profound dementia at end stages of the disease," he said.

ADDLs apparently form when certain inflammatory proteins are present
'"/>

Contact: Elizabeth Crown
e-crown@nwu.edu
312-503-8928
Northwestern University
25-May-1998


Page: 1 2 3

Related biology news :

1. NIEHS/NTP Director Dr. Kenneth Olden receives Society of Toxicologys Public Communications Award
2. Toxic protein could explain Alzheimers and lead to breakthroughs
3. Toxicogenomics provides insight on assigning breast cancer drugs
4. Toxic compound opens potentially important cell gates
5. Toxicologists discover traces of diesel exhaust in the body
6. National Toxicology Program (NTP) public meeting on the report on carcinogens
7. Pollutants Found In House Dust Increase Pesticides Toxicity
8. Mixing Radiation, Minerals, Toxic Waste Could Be Cleanup Boon -- Or Kaboom
9. Toxicologists To Meet March 14-18 In New Orleans
10. Duke Study Finds More Genes May Be Affected By Toxic Cadmium
11. Flexibility In Cutting Toxic Releases Yields Dividends

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/31/2018)... ... July 31, 2018 , ... GSL Biotech ... with LabArchives , the leading cloud-based Electronic Lab Notebook (ELN) platform. , ... researchers to store all of their research data records in a secure, compliant online ...
(Date:7/29/2018)... ... 29, 2018 , ... Dr. William Plikerd, an evidence-based energy healer, today announces ... immunity and to combat inflammation and autoimmune disorders. , The preclinical research assessed ... reported:, Up to 260% increase overall immunity as seen ...
(Date:7/26/2018)... ... July 25, 2018 , ... Boston Biotech Conferences will ... 4, 2018 at The Hilton Boston Back Bay Hotel. This peer-to-peer meeting provides ... and dissect the most relevant deals in biotech. , George Golumbeski recently joined ...
Breaking Biology News(10 mins):
(Date:8/7/2018)... ... August 06, 2018 , ... Slone Partners, ... the placement of Dr. Paul Harney as President, North America at Prescient Healthcare ... and enhancing client satisfaction. He was also named to Prescient’s Board of Directors. ...
(Date:7/31/2018)... ... July 31, 2018 , ... ... years, announces the launch of their new website. The new website has been ... the site. Mahoney partnered with Proceed Innovative to build a website created for ...
(Date:7/25/2018)... ... July 25, 2018 , ... Vium, Inc. ... Digital Vivariumâ„¢ and Vium Cloud approach to accelerate preclinical drug discovery and development, ... the company announced the appointment of Jeff Caron to the newly formed role ...
(Date:7/24/2018)... ... July 24, 2018 , ... R3 Stem Cell is now offering regenerative therapies ... offered by Double Board Certified providers, with outcomes significantly improving patient quality of life. ... have done nothing to help repair and regenerate damaged lung tissues. Stem cell ...
Breaking Biology Technology:
Cached News: