HOME >> BIOLOGY >> NEWS
Toxic compound opens potentially important cell gates

A compound previously noted mainly for its role in disease and the self-destruction of sick cells is more than just a jobless, toxic transient in healthy cells, researchers have found.

Scientists from The Johns Hopkins University, Harvard University and The University of Hawaii have reported new evidence rehabilitating the reputation of this biological pariah, known as adenosine diphosphate ribose, or ADP-ribose. They found that as cells work to break the compound down, a pause in the disposal process allows ADP-ribose to open a gate for transporting calcium through cell membranes in the brain, lungs, heart, spleen, liver, kidney, and elsewhere.

"It's important to know what opens and closes calcium channels, because calcium transport into and out of cells is a significant step in a wide variety of physiological processes," says Maurice Bessman, professor of biology in the Krieger School of Arts and Sciences at Hopkins and an author of a paper in the May 31 issue of "Nature." "Examples include nerve cell signaling processes, regulation of the heartbeat and muscle contraction, immune system responses, olfaction, and energy metabolism."

Researchers found evidence that a protein originally used solely to break down ADP-ribose had become fused with a protein that creates a calcium channel known as LTRPC2. A key segment of the disposal protein apparently was incorporated through evolution into the larger protein that creates the calcium channel.

"Two different processes -- two old functions -- have been very tightly tied together, but they're both still carrying out their own individual enzymatic reactions," Bessman says. "You get a whole that is greater than the sum of its parts. We don't think this is the last example of this type of fusion, and will be looking for other similar proteins usurped for other functions in a comparable fashion."

Discovery of the link began when
'"/>

Contact: Michael Purdy
mcp@jhu.edu
410-516-7160
Johns Hopkins University
5-Jun-2001


Page: 1 2 3

Related biology news :

1. NIEHS/NTP Director Dr. Kenneth Olden receives Society of Toxicologys Public Communications Award
2. Toxic protein could explain Alzheimers and lead to breakthroughs
3. Toxicogenomics provides insight on assigning breast cancer drugs
4. Toxicologists discover traces of diesel exhaust in the body
5. National Toxicology Program (NTP) public meeting on the report on carcinogens
6. Pollutants Found In House Dust Increase Pesticides Toxicity
7. Mixing Radiation, Minerals, Toxic Waste Could Be Cleanup Boon -- Or Kaboom
8. Toxicologists To Meet March 14-18 In New Orleans
9. Duke Study Finds More Genes May Be Affected By Toxic Cadmium
10. Flexibility In Cutting Toxic Releases Yields Dividends
11. Wistar Scientist To Speak At Toxicology Forum On Effects Of Conjugated Linoleic Acid On Preventing And Reversing Atherosclerosis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/2/2020)... ... July 01, 2020 , ... ... 1a findings of Neihulizumab, a biologic for the treatment of steroid-refractory acute graft-versus-host ... by hemato-oncologist Dr. Paul J Martin of the Fred Hutchinson Cancer Research Center, ...
(Date:7/1/2020)... ... July 01, 2020 , ... Cure Glioblastoma, ... glioblastoma—the most common and aggressive adult brain cancer—announced today the appointments of its ... are charged with supporting the organization’s initiatives and overall vision. , "Senior Fellows ...
(Date:6/25/2020)... Mass. (PRWEB) , ... June 24, 2020 , ... ... of cloud-based enterprise software and software-driven clinical data services that accelerate drug development, ... for low-dose selinexor, an XPO1 inhibitor, in hospitalized patients with severe COVID-19. This ...
Breaking Biology News(10 mins):
(Date:7/18/2020)... (PRWEB) , ... July 16, 2020 , ... ... solutions to aid in the early detection and prevention of high-burden diseases, and ... enable US-based hospitals and healthcare organizations to utilize existing data in order to ...
(Date:7/10/2020)... (PRWEB) , ... July 09, 2020 , ... ... to cell therapy, today announced the hiring of Allen R. Nissenson, M.D., F.A.C.P., ... and oversee the clinical development of Sentien’s lead product, SBI-101. Dr. Nissenson ...
(Date:7/1/2020)... ... June 30, 2020 , ... ... announced that the launch of a new clinical diagnostics immuno-oncology service, ... tumor microenvironment (TME). , “Flagship’s TissueInsight is a service that aids pathologists, ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... lab-made bioresearch materials, today announced the availability of the Delta-G-VSV Pseudotyping System for ... of Tennessee, enables studies of SARS-CoV-2 viral entry and COVID-19 vaccine effectiveness at ...
Breaking Biology Technology:
Cached News: