HOME >> BIOLOGY >> NEWS
Toxic protein could explain Alzheimer's and lead to breakthroughs

EVANSTON, Ill. -- Researchers at Northwestern University have discovered for the first time in humans the presence of a toxic protein that they believe to be responsible for the devastating memory loss found in individuals suffering from Alzheimer's disease.

An understanding of this key molecular link in the progression of Alzheimer's could lead to the development of new therapeutic drugs capable of reversing memory loss in patients who are treated early, in addition to preventing or delaying the disease. Help for individuals with pre-Alzheimer's memory failure (mild cognitive impairment) also is envisioned. The findings will be published online by the Proceedings of the National Academy of Sciences during the week of Aug. 18.

The research team, led by William L. Klein, professor of neurobiology and physiology, found up to 70 times more small, soluble aggregated proteins called "amyloid b-derived diffusible ligands" (ADDLs, pronounced "addles") in the brain tissue of individuals with Alzheimer's disease compared to that of normal individuals.

The clinical data strongly support a recent theory in which ADDLs accumulate at the beginning of Alzheimer's disease and block memory function by a process predicted to be reversible. ADDLs have the ability to attack the memory-building activity of synapses, points of communication where neurons exchange information, without killing neurons.

"Researchers for more than a decade thought it was big molecules, the 'amyloid fibrils,' that caused memory problems, but we think the real culprits are extremely small molecules, what we call ADDLs," said Klein, who is a member of Northwestern's Cognitive Neurology and Alzheimer's Disease Center. "Now we've shown that ADDLs are present in humans and are a clinically valid part of Alzheimer's pathology. If we can develop drugs that target and neutralize these neurotoxins, it might be possible to not only slow down memory loss, but to actually reverse it, t
'"/>

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
18-Aug-2003


Page: 1 2 3

Related biology news :

1. NIEHS/NTP Director Dr. Kenneth Olden receives Society of Toxicologys Public Communications Award
2. Toxicogenomics provides insight on assigning breast cancer drugs
3. Toxic compound opens potentially important cell gates
4. Toxicologists discover traces of diesel exhaust in the body
5. National Toxicology Program (NTP) public meeting on the report on carcinogens
6. Pollutants Found In House Dust Increase Pesticides Toxicity
7. Mixing Radiation, Minerals, Toxic Waste Could Be Cleanup Boon -- Or Kaboom
8. Toxicologists To Meet March 14-18 In New Orleans
9. Duke Study Finds More Genes May Be Affected By Toxic Cadmium
10. Flexibility In Cutting Toxic Releases Yields Dividends
11. Wistar Scientist To Speak At Toxicology Forum On Effects Of Conjugated Linoleic Acid On Preventing And Reversing Atherosclerosis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/22/2020)... , ... April 21, 2020 , ... ... a patent leveraged venture capital firm that provides patent development support for early ... detect and treat illnesses such as ovarian cancer and precancerous pancreatic lesions with ...
(Date:4/16/2020)... ... April 15, 2020 , ... With the exploding number ... vaccine to this novel virus. In an effort to accelerate breakthroughs, including the ... is announcing the development of Sample.Exchange, a web-based platform that will allow ...
(Date:4/14/2020)... , ... April 14, 2020 , ... ... interactive virtual events and webinars, continues to provide cutting-edge research and findings about ... Genetics Virtual Week will feature more than 25 educational, scientific discussions, ...
Breaking Biology News(10 mins):
(Date:4/7/2020)... ... April 06, 2020 , ... Red Nucleus, a leading provider ... announced the release of at-home virtual learning resources for all client partners. , ... safety of our employees as we continue to implement measures to safeguard the ...
(Date:4/1/2020)... ... March 31, 2020 , ... Carterra® Inc., the world leader ... announced today that they will use Carterra’s proprietary LSA™ platform to screen hundreds of ... clinic as early as this summer. , La Jolla Institute for Immunology (LJI) ...
(Date:3/19/2020)... ... March 17, 2020 , ... RoosterBio ... circuit company Senti Biosciences, Inc. (Senti) to accelerate the clinical translation of ... The collaboration will leverage RoosterBio’s human mesenchymal stem/stromal cell (hMSC) bioprocess systems, ...
(Date:3/10/2020)... RARITAN, N.J. (PRWEB) , ... March 10, 2020 , ... ... saving lives through innovative laboratory solutions, announced its ORTHOTM Sera, ID-MTS, a suite of ... need of transfusion, is cleared to run on ORTHO VISION® and ORTHO VISION® Max ...
Breaking Biology Technology:
Cached News: