Toxic protein could explain Alzheimer's and lead to bre...( oying nanotechnology said Klein. Tha...)

Toxic protein could explain Alzheimer's and lead to breakthroughs

oying nanotechnology," said Klein. "That's because ADDLs are present in very low concentrations, and nanotechnology has the potential to provide the ultra-sensitive assays needed for the clinic."

Klein, Grant A. Krafft, formerly at Northwestern University Medical School and now chief scientific officer at Acumen Pharmaceuticals, Inc., and Caleb E. Finch, professor of biological sciences and gerontology at the University of Southern California, reported the discovery of ADDLs in 1998. Krafft and Finch are co-authors on the PNAS paper. Northwestern and USC hold joint patents on the composition and use of ADDLs in neurodisorders.

The patent rights have been licensed to Acumen Pharmaceuticals, based in Glenview, Ill., for the development of drugs that treat Alzheimer's disease and other memory-related disorders. Clinical trials could be two or three years away.

In addition to Klein, Krafft and Finch, other authors on the paper are Yuesong Gong (lead author), Lei Chang, Kirsten L. Viola, Pascale N. Lacor and Mary P. Lambert, from Northwestern University.

'"/>

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
18-Aug-2003

Page: 1 2 3
Related biology news :

1. NIEHS/NTP Director Dr. Kenneth Olden receives Society of Toxicologys Public Communications Award
2. Toxicogenomics provides insight on assigning breast cancer drugs
3. Toxic compound opens potentially important cell gates
4. Toxicologists discover traces of diesel exhaust in the body
5. National Toxicology Program (NTP) public meeting on the report on carcinogens
6. Pollutants Found In House Dust Increase Pesticides Toxicity
7. Mixing Radiation, Minerals, Toxic Waste Could Be Cleanup Boon -- Or Kaboom
8. Toxicologists To Meet March 14-18 In New Orleans
9. Duke Study Finds More Genes May Be Affected By Toxic Cadmium
10. Flexibility In Cutting Toxic Releases Yields Dividends
11. Wistar Scientist To Speak At Toxicology Forum On Effects Of Conjugated Linoleic Acid On Preventing And Reversing Atherosclerosis

Post Your Comments:

(Date:11/6/2009)...th of the publication of On the Origin of Species,...BS) is publishing open access two peer-reviewed ar...hts into evolution. , The two articles are by Kev...y, and James T. Costa of Western Carolina Universi...win," appeared in the October issue of the AIBS jo...

(Date:11/6/2009)...Hills, MI-based Law Enforcement Intelligent Device... and patent-pending Biometric Access Control Syste...Human Services, National Institutes of Health (NIH...upport the NIH,s entire police force that is respo...h agency. The project is expected to be completed...

(Date:11/5/2009)...s (NABT) will recognize Leonard C. Yannielli, prof...ommunity College (NVCC) in Waterbury, Connecticut,...e NABT annual professional development conference .... , The Evolution Education Award is cosponsored...,(AIBS) and Biological Sciences Curriculum Study (...

Breaking Biology News(10 mins):Biologists, educators recognize excellence in evolution education 2 Study Suggests Vitamin D Screening and Appropriate Supplementation Indicated for All Cancer Patients 4594 1 Study Suggests Vitamin D Screening and Appropriate Supplementation Indicated for All Cancer Patients 4594 2 Protein regulates movement of mitochondria in brain cells 8823 1 Protein regulates movement of mitochondria in brain cells 8823 2 Protein regulates movement of mitochondria in brain cells 8823 3 PDI Inc Announces New Business Wins Exceeding 2418 Million 48879 1 PDI Inc Announces New Business Wins Exceeding 2418 Million 48879 2 PDI Inc Announces New Business Wins Exceeding 2418 Million 48879 3

[0] AIBS publishes Darwin articles open access [0] National Institutes of Health Secures Armory with Patent-Pending Technology [0] Biologists, educators recognize excellence in evolution education

(Date:11/5/2009)...ference Call on Thursday, November 5, 2009 at 4:30...R Nov. 5 /PRNewswire-FirstCall/ - OncoGenex Pharma...SDAQ: OGXI ) today reported unaudited financial r... September 30, 2009 and reviewed the Company,s hig...ollowing consolidated results reflect the operatio...

(Date:11/5/2009)... DIEGO, CA, November 5, 2009 /PRNewswire-FirstCall...used on using proprietary taste receptor-based tec... the food, beverage, and ingredient supply industr...d financial results for the third quarter ended Se...the third quarter of 2009, compared to $4.0 millio...

(Date:11/5/2009)... LASIK Surgery and vision correcti...rectory were actively involved at the recently con...9 Annual Meeting in San Francisco, California. Dr.... Dr. Jonathan Davidorf, MD, Dr. Peter Rapoza, MD, ...r. R. Wayne Bowman, MD, Dr. Edward Manche, MD, and...

(Date:11/4/2009)...ERSBURG, Va., Nov. 4 S...today that the company plans to introduce the CigR...diary, Rock Creek Pharmaceuticals, for worldwide m...Health, Inc . (Nasdaq: VTIV). inVentiv Health of...ns for every stage of the product lifecycle, in a ...

[0] OncoGenex Reports Third Quarter 2009 Financial Results [0] SENOMYX ANNOUNCES CORPORATE UPDATE AND THIRD QUARTER 2009 FINANCIAL RESULTS [0] Leading Vision Correction Experts in Trusted LASIK Surgeons Directory Educate Fellow Doctors at AAO Annual Meeting [0] Star Scientific Plans Worldwide Marketing and Sales of CigRx(TM) Nutraceutical in Partnership with inVentiv Health

Other News:

.Torrential rains from Hurricane Floyd have resulted in widespread flooding in.southeast Virginia. Flooding along the Blackwater River in Southampton County is.extensive, and river stage is still risi

. CLEMSON -- The dramatic boom in the sale of land along the South Carolina.coast is not due solely to the soothing effects of the surf, the lure of the.warm seas breezes or the taste of fresh

... GEORGETOWN-- To look at the natural forests...oared through South Carolina just 10 years ago, sa... ecologist.. Hugo's 1989 trek through the s...in 23 South Carolina counties. After the hurrican...

...eavy rains have occurred as Floyd moved into easte... some rivers in southeastern Virginia are already ...toway, and Blackwater Rivers..Numerous smaller str...g...Last night and early this morning, USGS person...

Clemson researchers link federal flood insurance program to accelerated coastal development 2 Clemson's Baruch Forest Science Institute tracks forests' recovery from hurricane,damage 2 Clemson's Baruch Forest Science Institute tracks forests' recovery from hurricane,damage 3 USGS responds to Hurricane Floyd in Virginia 2

Hurricane Floyd brings record flooding to southeast Virginia Clemson researchers link federal flood insurance program to accelerated coastal development Clemson's Baruch Forest Science Institute tracks forests' recovery from hurricane,damage USGS responds to Hurricane Floyd in Virginia

...ed in the July 2006 issue of Global Change Biology...urtt, Steve Frolking, and coauthors show that land...antially altered the land surface in ways that are...system. Land-use changes have impacted some 42-68 ...

...3 HIV infection of T cells requires activation of...hat reveals yet another pathway the virus uses in ...University of Pittsburgh Graduate School of Public...in PLoS Pathogens, an open-access journal publishe...

...provides an unexpected link between asthma and obe...an Institute, who are also part of the Cooperative...ett Shum and colleagues have found that a fatty ac...own for its role in diabetes and obesity, is also ...

...ssue of G&D, Dr. Marina Antoch and colleagues (The...en the innate biological clock known as the circa...nsgenic mice lacking the core circadian clock gene... BMAL1 also plays an important role in aging. Bmal...

Centuries of land-use practices profoundly impact earth system, UNH scientists report 2 HIV infection requires B cells with special protein, University of Pittsburgh researchers report 2

Centuries of land-use practices profoundly impact earth system, UNH scientists report HIV infection requires B cells with special protein, University of Pittsburgh researchers report Asthma -- obesity connection The aging-clock connection