HOME >> BIOLOGY >> NEWS
Toxicogenomics provides insight on assigning breast cancer drugs

DENVER, CO -- Toxicology is getting a facelift with an infusion of genomics and proteomics--and powerful computing--that will help researchers predict adverse effects to chemicals in the environment, as well as the effectiveness of drugs used to treat breast cancer patients.

Knowing how a person's body would allow a toxic effect to occur at the gene and protein level, may someday make it easier for doctors to decide what treatment is more appropriate. Such information also would lead to the development of better biomarkers to detect toxicity earlier during medical treatment, researchers said today at the 2003 American Association for the Advancement of Science (AAAS) Annual Meeting.

Like a wad of gum stuck in a child's hair, a small breast cancer cell from a tissue mass requires delicate unraveling and extraction. Traditionally, researchers have studied the genetics of the whole tumor mass because of the difficulty faced when trying to excise the cell of interest. Now, Emanuel Petricoin of the Food and Drug Administration has been working with a special video-game like microscope that pulls selected cells out, like a tractor beam. When combined with new protein array technologies he and his colleague Lance Liotta (National Cancer Institute) have also been developing, the new microscope technology has allowed him to study toxicity and the cancer-associated "miswiring" of the cellular circuitry in breast cancer patients receiving different kinds of drugs or combination of drugs.

After the cell is isolated from the tumor mass, it is ready to have its proteome (the protein complement encoded by a person's genome) analyzed. To do this, Petricoin has also developed protein array tests to detect subtle changes in protein phosphorylation along many key "nodes" within the cellular circuitry. Phosphorylation occurs when a phosphate group is removed from ATP, a component in many cellular circuits. While it is possible to know of the existence of a ge
'"/>


14-Feb-2003


Page: 1 2 3

Related biology news :

1. Study by Israeli scientists provides insight on DNA code
2. Study by Tufts biologist provides window into progression of some degenerative diseases
3. Rolling Store provides model for overcoming barriers to healthy foods and better health outcomes
4. Common worm provides insights into salmonella virulence
5. Avastin-Tarceva combo provides one-two punch against lung cancer
6. Motion that powers sperm provides key to unravelling rare genetic disorder
7. Chemical reaction in birds provides sense of direction during migratory flights
8. Engineered virus provides impetus in search for HIV vaccine
9. Pollution history documented through shell remains provides tool to study ecosystem change
10. Microbes trick provides a template for willowy crystals
11. Migraine mouse provides insight into neurobiology of devastating headaches

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/1/2019)... ... 2019 , ... Advancements with Ted Danson to focus on ... , Factor Bioscience Inc. (Factor) is pioneering nucleic-acid and cell-based technologies to advance ... of Advancements will explore how Factor Bioscience is building the future of regenerative ...
(Date:7/26/2019)... ... July 25, 2019 , ... Lemnis Technologies, ... reality headsets to include a new generation eye tracker with hassle-free calibration. The ... Angeles, California (July 30 - August 1). SIGGRAPH attendees will be able to ...
(Date:7/23/2019)... , ... July 22, 2019 , ... Personalized Stem Cells, ... New Drug (IND) application for use of a person’s own adipose-derived stem cells to ... cells as a treatment of osteoarthritis in the knee. , This is ...
Breaking Biology News(10 mins):
(Date:7/17/2019)... ... July 16, 2019 , ... Quidel is ... from Kalorama Information. Abbott, Roche and Siemens Healthineers and Response Biomedical also are ... Worldwide Market for Point-of-Care (POC) Diagnostics . , Quidel is a market ...
(Date:7/9/2019)... Iowa (PRWEB) , ... July 08, 2019 , ... Today, ... Moines, Iowa, the National Corn Growers Association (NCGA) announced the winners of ... to improve a product or process using field corn to produce biobased materials. , ...
(Date:7/2/2019)... ... 02, 2019 , ... Leading Regenerative Veterinary Medicine company, VetStem Biopharma , ... The film focuses on regenerative veterinary medicine as a means of improving the ... included in the Brentwood and Pacific Palisades International Film Festival in Los Angeles, ...
(Date:6/18/2019)... ... June 17, 2019 , ... IVERIC ... into an agreement for production and manufacturing of GMP-grade adeno-associated virus (AAV) vector ... autosomal dominant retinitis pigmentosa (RHO-adRP) and IC-200 for the treatment of BEST1 related ...
Breaking Biology Technology:
Cached News: