HOME >> BIOLOGY >> NEWS
Transplant cells show capacity for mending nervous system

MADISON - Using stem cells grown in the laboratory, scientists have successfully transplanted those cells into the nervous systems of ailing rats and arrested the course of a debilitating congenital disease.

Although accomplished in rats and still some years from clinical application, the work is important because it shows that cells grown from scratch can be used to repair defective nerves. The report was published this week (Friday, July 30) in the journal Science by a team of scientists from the University of Bonn Medical Center, the National Institute of Neurological Disorders and Stroke (NINDS) and the University of Wisconsin-Madison.

The work was accomplished using embryonic stem cells, ephemeral cells that arise within days of conception in a fertilized egg and very quickly develop into all the different kinds of cells -- blood, bone, muscle, neurons -- that make up the body. Such cells hold enormous therapeutic potential to treat disease through the promise of unlimited supplies of laboratory-grown replacement tissue to treat many congenital and acquired diseases, including heart disease, neurological disorders such as Parkinson's disease or multiple sclerosis, and other diseases such as diabetes.

In the new study, stem cells were coaxed down a developmental pathway to become oligodendrocytes and astrocytes, key cells of the central nervous system. Transplanted into the spinal cords of fetal and newborn rats that lack myelin, a tissue that covers some nerve fibers, the cells were observed to promote the growth of the myelin sheaths essential to the ability of nerves to conduct electrical impulses and function normally.

"This is the first study showing that embryonic stem cells can be used for brain and spinal cord repair in an animal model of a human neurological disease," said Oliver Brüstle, a neuropathologist at the University of Bonn and first author of the paper.

Ronald D.G. McKay, chief of th
'"/>

Contact: Ian Duncan
duncani@svm.vetmed.wisc.edu
608-263-9828
University of Wisconsin-Madison
29-Jul-1999


Page: 1 2 3

Related biology news :

1. Transplant rejection averted by simple light exposure in Stanford animal study
2. Media invited to attend International Society For Heart & Lung Transplantation meeting April 21-24
3. Transplantation of embryonic pancreatic tissue controls Type 1 diabetes in rats
4. Cell Transplant Society holds 6th International Congress in Atlanta March 2-5
5. Transplant patients from 40 years ago cause Pittsburgh doctors to take an about-face
6. Transplantation Society Congress
7. Transplanted stem cells restore function in stroke
8. Artificial lung on the horizon, reports University of Pittsburgh researcher at International Society for Heart and Lung Transplantation meeting
9. Transplanted human stem cells develop into broad range of tissues, persist over a year in research at The Childrens Hospital of Philadelphia
10. Omaha to host International Small Bowel Transplant Symposium
11. Transplanted neural stem cells migrate throughout the abnormal brain, reduce disease symptoms

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2016)... BANGALORE, India , April 28, 2016 ... subsidiary of Infosys (NYSE: INFY ), and Samsung ... global partnership that will provide end customers with a ... and payment services.      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ... for financial services, but it also plays a fundamental part ...
(Date:4/15/2016)... , April 15, 2016  A new ... make more accurate underwriting decisions in a fraction ... timely, competitively priced and high-value life insurance policies ... screenings. With Force Diagnostics, rapid testing ... lifestyle data readings (blood pressure, weight, pulse, BMI, ...
(Date:3/31/2016)... PROVIDENCE, R.I. , March 31, 2016  Genomics ... leadership of founding CEO, Barrett Bready , M.D., ... addition, members of the original technical leadership team, including ... Vice President of Product Development, Steve Nurnberg and Vice ... have returned to the company. Dr. Bready ...
Breaking Biology News(10 mins):
(Date:5/27/2016)... ... 27, 2016 , ... Weeks after hosting a carpal tunnel syndrome workshop with ... surgeon and founder of the Fitzmaurice Hand Institute, has announced the addition of MRI ... state-of-the-art technology and only 1 of about 3 currently available in the United States. ...
(Date:5/26/2016)... Mich. , May 26, 2016  Agriculture nutrients ... Des Moines, Iowa is running their ... Lake Erie and coastal regions ... key to preventing this widespread issue. NECi ... Upper Peninsula, developed a new, easy to ...
(Date:5/26/2016)... , ... May 26, 2016 , ... ... company, today announced several positive developments that position the Company for the future. ... of the transaction, Craig F. Kinghorn has been appointed Chairman of the Board, ...
(Date:5/25/2016)... ... 25, 2016 , ... Founder of the Fitzmaurice Hand Institute ... surgery of the hand by the National Board of Physicians and Surgeons, as ... beyond in his pursuit of providing the most comprehensive, effective treatment for his ...
Breaking Biology Technology:
Cached News: