HOME >> BIOLOGY >> NEWS
Transplant cells show capacity for mending nervous system

MADISON - Using stem cells grown in the laboratory, scientists have successfully transplanted those cells into the nervous systems of ailing rats and arrested the course of a debilitating congenital disease.

Although accomplished in rats and still some years from clinical application, the work is important because it shows that cells grown from scratch can be used to repair defective nerves. The report was published this week (Friday, July 30) in the journal Science by a team of scientists from the University of Bonn Medical Center, the National Institute of Neurological Disorders and Stroke (NINDS) and the University of Wisconsin-Madison.

The work was accomplished using embryonic stem cells, ephemeral cells that arise within days of conception in a fertilized egg and very quickly develop into all the different kinds of cells -- blood, bone, muscle, neurons -- that make up the body. Such cells hold enormous therapeutic potential to treat disease through the promise of unlimited supplies of laboratory-grown replacement tissue to treat many congenital and acquired diseases, including heart disease, neurological disorders such as Parkinson's disease or multiple sclerosis, and other diseases such as diabetes.

In the new study, stem cells were coaxed down a developmental pathway to become oligodendrocytes and astrocytes, key cells of the central nervous system. Transplanted into the spinal cords of fetal and newborn rats that lack myelin, a tissue that covers some nerve fibers, the cells were observed to promote the growth of the myelin sheaths essential to the ability of nerves to conduct electrical impulses and function normally.

"This is the first study showing that embryonic stem cells can be used for brain and spinal cord repair in an animal model of a human neurological disease," said Oliver Brüstle, a neuropathologist at the University of Bonn and first author of the paper.

Ronald D.G. McKay, chief of th
'"/>

Contact: Ian Duncan
duncani@svm.vetmed.wisc.edu
608-263-9828
University of Wisconsin-Madison
29-Jul-1999


Page: 1 2 3

Related biology news :

1. Transplant rejection averted by simple light exposure in Stanford animal study
2. Media invited to attend International Society For Heart & Lung Transplantation meeting April 21-24
3. Transplantation of embryonic pancreatic tissue controls Type 1 diabetes in rats
4. Cell Transplant Society holds 6th International Congress in Atlanta March 2-5
5. Transplant patients from 40 years ago cause Pittsburgh doctors to take an about-face
6. Transplantation Society Congress
7. Transplanted stem cells restore function in stroke
8. Artificial lung on the horizon, reports University of Pittsburgh researcher at International Society for Heart and Lung Transplantation meeting
9. Transplanted human stem cells develop into broad range of tissues, persist over a year in research at The Childrens Hospital of Philadelphia
10. Omaha to host International Small Bowel Transplant Symposium
11. Transplanted neural stem cells migrate throughout the abnormal brain, reduce disease symptoms

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/29/2016)... 29, 2016 Nearly one billion matches per second ... ... DERMALOG is Germany's ... efficient Identity Management. (PRNewsFoto/DERMALOG Identification Systems) ... DERMALOG is Germany's largest Multi-Biometric supplier: The company's Fingerprint Identification ...
(Date:11/21/2016)... , Nov. 21, 2016   Neurotechnology , ... recognition technologies, today announced that the MegaMatcher On ... was submitted for the NIST Minutiae Interoperability ... all the mandatory steps of the evaluation protocol. ... a continuing test of fingerprint templates used to ...
(Date:11/15/2016)... , Nov. 15, 2016  Synthetic Biologics, ... developing therapeutics focused on the gut microbiome, today ... of 25,000,000 shares of its common stock and ... stock at a price to the public of ... to Synthetic Biologics from the offering, excluding the ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... , Dec. 8, 2016  Soligenix, Inc. ... biopharmaceutical company focused on developing and commercializing products ... unmet medical need, announced today the long-term follow-up ... SGX942 (dusquetide), a first-in-class Innate Defense Regulator (IDR), ... head and neck cancer patients undergoing chemoradiation therapy ...
(Date:12/8/2016)... -- Partnering to fuel Philadelphia,s innovative ... Southeastern Pennsylvania (" Ben Franklin "); ... Blue Cross; and Safeguard Scientifics ("Safeguard") (NYSE: ... million funding initiative over a four year period to ... a burgeoning economic vitality in digital health, Ben ...
(Date:12/7/2016)... LANSING, Mich. , Dec. 7, 2016 ... it has named Dr. Dan Kephart as ... the company. Kephart will assume his responsibilities at Neogen ... research and development director for the agribusiness unit of ... food safety development at Life Technologies. His extensive industry ...
(Date:12/7/2016)... 2016 The report "Acrylic Processing Aid Market by Polymer Type (PVC), ... Goods) - Global Forecast to 2026", published by MarketsandMarkets, the global market size ... Million by 2026, registering an of CAGR of 6.2% between 2016 and 2026. ... ... MarketsandMarkets Logo ...
Breaking Biology Technology:
Cached News: