HOME >> BIOLOGY >> NEWS
Transplanted Skeletal Muscle Mimics Heart Muscle; Helps Failing Heart Pump, Duke,,Researchers Say

DURHAM, N.C. -- Immature muscle cells transplanted from the leg of an animal to its heart apparently can "learn" to act like heart muscle, significantly boosting the ability of damaged hearts to contract, Duke researchers have found.

The researchers say it is a promising first step toward a simple transplant procedure that could augment current treatment for damaged hearts.

The experiments, reported in the August issue of the journal Nature Medicine, show that a tiny plug of muscle taken from an animal's leg and injected into the same animal's severely damaged heart muscle can boost contraction between 34 percent and 100 percent compared to non-treated animals.

"We were excited to see that in many of our test animals, contractions began to approach that of a normal animal," said Duke molecular biologist and heart researcher Doris Taylor. "In addition, when we examined the hearts of the treated animals, we found that their heart tissue was less stiff than if we had not treated the animals, meaning the heart could stretch better. The treated heart was not as rigid as a failing heart."

Taylor said her research team, which also included surgeons Dr. Donald Glower and Dr. Zane Atkins, cardiologist Dr. Willam Kraus, and researchers Pinata Hungspreugs, Thomas Jones, Mary Reedy, and Kelley Hutcheson, hopes to test the therapy by next year in patients with severe heart failure who are awaiting heart transplants. The research was funded in part by the American Heart Association and a grant from the National Science Foundation Engineering Research Center.

The researchers said they hope eventually to combine their treatment with existing therapies to prevent heart failure. They envision that when a patient comes to the emergency room with a heart attack, doctors would remove a small plug of cells from the leg and grow them in the laboratory for about two weeks, long enough to assess damage to the heart and for the im
'"/>

Contact: Karyn Hede George
George016@mc.duke.edu
919-684-4148
Duke University Medical Center
4-Aug-1998


Page: 1 2 3 4

Related biology news :

1. Transplanted stem cells restore function in stroke
2. Transplanted human stem cells develop into broad range of tissues, persist over a year in research at The Childrens Hospital of Philadelphia
3. Transplanted neural stem cells migrate throughout the abnormal brain, reduce disease symptoms
4. Skeletal Muscle Yields Precursors Of Bone Cells That Form Bone When Transplanted Into Animals
5. Three Institutions Combine Efforts In First-Ever Demonstration Of Long-Term Function In Transplanted Human Liver Cells
6. Transplanted Neurons Restore Function In Rats After Stroke
7. Muscles are smarter than you think
8. Muscle-derived cells and gene therapy may cure for post-prostatectomy erectile dysfunction
9. Muscle protein has role in nerve disorders
10. Muscle-repair defect underlies two muscular dystrophies
11. Muscle derived cell transplants offer alternative incontinence therapy says Pitt study

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2017)... 2017 The research team of The Hong ... fingerprint identification by adopting ground breaking 3D fingerprint minutiae recovery and ... speed and accuracy for use in identification, crime investigation, immigration control, ... ... A research team led ...
(Date:3/28/2017)... India , March 28, 2017 ... IP, Biometrics), Hardware (Camera, Monitors, Servers, Storage Devices), Software ... Vertical, and Region - Global Forecast to 2022", published ... Billion in 2016 and is projected to reach USD ... between 2017 and 2022. The base year considered for ...
(Date:3/24/2017)... , Mar 24, 2017 Research and ... Access System Market Analysis & Trends - Industry Forecast to 2025" ... ... to grow at a CAGR of around 15.1% over the next ... This industry report analyzes the market estimates and forecasts for all ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... Philadelphia, PA (PRWEB) , ... October 10, 2017 ... ... University City Science Center’s FirstHand program has won a US2020 STEM Mentoring Award. ... accept the award for Excellence in Volunteer Experience from US2020. , US2020’s mission ...
(Date:10/10/2017)... ... October 10, 2017 , ... The Pittcon Program Committee ... honoring scientists who have made outstanding contributions to analytical chemistry and applied ... the world’s leading conference and exposition for laboratory science, which will be held ...
(Date:10/9/2017)... ... October 09, 2017 , ... ... October 5, 2017, in the medical journal, Epilepsia, Brain Sentinel’s SPEAC® System ... standard, video EEG, in detecting generalized tonic-clonic seizures (GTCS) using surface electromyography ...
(Date:10/6/2017)... ... 06, 2017 , ... On Tuesday, October 24th, ABC² (Accelerate ... first-ever adaptive clinical trial for glioblastoma (GBM). The featured speaker will be Dr. ... open to the public, but registration is required. , WHAT: ABC² Brain ...
Breaking Biology Technology:
Cached News: