HOME >> BIOLOGY >> NEWS
Transplanted Skeletal Muscle Mimics Heart Muscle; Helps Failing Heart Pump, Duke,,Researchers Say

mune system to return to normal. Then the cells would be delivered with a catheter, a device now commonly used to clear blocked arteries.

"Even if the cells only boosted contraction by 10 or 15 percent, that could mean a significant difference in a patient's quality of life," Taylor said.

Taylor began her experiments several years ago with the hope of providing some way to prevent hearts that were damaged by severe heart attacks from progressing to heart failure. Currently there is no way to reverse damage done to the heart during an extended period of low oxygen, as occurs in a severe heart attack. Although the remaining heart muscle cells grow larger to compensate, that only makes the heart more inefficient. Cardiologists rely on quickly removing blockages in arteries with clot busting agents. But in cases where the heart is damaged, it can't repair itself. The result can be congestive heart failure, a chronic condition that kills more than 41,000 people annually in the United States and Europe.

"Treatments for severe heart failure are currently limited to making the remaining heart work better or heart transplantation," Taylor said. "You are born with all the heart cells you'll ever have. Once you damage the heart muscle, it's gone forever."

Yet as any body builder knows, if you strain your biceps pumping iron they respond by building new muscle. In a deceptively simple idea, Taylor decided to try to recruit the services of individual skeletal muscle cells, called myoblasts, to actually regenerate dead heart muscle.

"Our hope is that, as a first step to treating patients, transplanted cells may boost the heart's ability to contract, at least long enough for a new heart to become available. When the failed heart is removed, we will be able to see if the engrafted cells performed as in our preliminary tests."

The technique is different from any other that has been tried for treating heart failur
'"/>

Contact: Karyn Hede George
George016@mc.duke.edu
919-684-4148
Duke University Medical Center
4-Aug-1998


Page: 1 2 3 4

Related biology news :

1. Transplanted stem cells restore function in stroke
2. Transplanted human stem cells develop into broad range of tissues, persist over a year in research at The Childrens Hospital of Philadelphia
3. Transplanted neural stem cells migrate throughout the abnormal brain, reduce disease symptoms
4. Skeletal Muscle Yields Precursors Of Bone Cells That Form Bone When Transplanted Into Animals
5. Three Institutions Combine Efforts In First-Ever Demonstration Of Long-Term Function In Transplanted Human Liver Cells
6. Transplanted Neurons Restore Function In Rats After Stroke
7. Muscles are smarter than you think
8. Muscle-derived cells and gene therapy may cure for post-prostatectomy erectile dysfunction
9. Muscle protein has role in nerve disorders
10. Muscle-repair defect underlies two muscular dystrophies
11. Muscle derived cell transplants offer alternative incontinence therapy says Pitt study

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... N.Y. , April 11, 2017 ... fingerprints, but researchers at the New York University ... College of Engineering have found that partial similarities ... security systems used in mobile phones and other ... thought. The vulnerability lies in the ...
(Date:4/5/2017)... Today HYPR Corp. , leading innovator ... of the HYPR platform is officially FIDO® Certified ... architecture that empowers biometric authentication across Fortune 500 enterprises ... over 15 million users across the financial services industry, ... product suites and physical access represent a growing portion ...
(Date:3/30/2017)... ANGELES , March 30, 2017  On April ... Hack the Genome hackathon at Microsoft,s ... exciting two-day competition will focus on developing health and ... Hack the Genome is the ... been tremendous. The world,s largest companies in the genomics, ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... BioMedGPS ... the addition of its newest module, US Hemostats & Sealants. , SmartTRAK’s US ... absorbable hemostats, fibrin sealants, synthetic sealants and biologic sealants used in surgical applications. ...
(Date:10/11/2017)... ... October 11, 2017 , ... The ... endogenous context, enabling overexpression experiments and avoiding the use of exogenous expression plasmids. ... is transformative for performing systematic gain-of-function studies. , This complement to loss-of-function ...
(Date:10/11/2017)... -- VMS BioMarketing, a leading provider of patient support solutions, has ... (CNE) network, which will launch this week. The VMS CNEs ... professionals to enhance the patient care experience by delivering peer-to-peer ... care professionals to help women who have been diagnosed and ... ...
(Date:10/11/2017)... ... October 11, 2017 , ... Singh Biotechnology today ... designation to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of Transcription 3) ... able to cross the cell membrane and bind intracellular STAT3 and inhibit its ...
Breaking Biology Technology:
Cached News: