HOME >> BIOLOGY >> NEWS
Transplanted Skeletal Muscle Mimics Heart Muscle; Helps Failing Heart Pump, Duke,,Researchers Say

e. For example, another new experimental procedure, called cardiomyoplasty, uses skeletal muscles taken from a patient's back or abdomen to wrap around an ailing heart. The muscle is stimulated by a device similar to a pacemaker to augment weak heart muscle. But, Taylor said, the skeletal muscle isn't really hooked up to the heart. It acts more like a mechanical assist device.

"Our idea is similar to earlier experiments by researchers at other universities who are trying to implant fetal muscle cells into hearts to stimulate growth," Taylor said. But, she added, that idea is not practical because there is no ready supply of fetal tissue and it could cause an immune reaction. The advantage of using muscle cells from each patient is that it's their own tissue, which won't be rejected by the immune system.

The Duke research team is testing the idea using rabbits, which have hearts very similar to a human heart. "Unlike some animals, rabbits have heart attacks just like people," Taylor said.

The researchers injected the damaged hearts of 12 rabbits with 10 million muscle cells. In seven of the 12, the cells took up residence and began stretching and contracting. In addition, when the researchers examined the hearts three to six weeks later, the skeletal muscle cells had organized themselves in a pattern resembling heart muscle cells, suggesting that the skeletal muscle had somehow "learned" how to act like heart muscle.

"We were very encouraged to see that the engrafted cells appear to adapt to their local environment and mimic heart muscle," Taylor said. "We had been concerned that the skeletal muscle could induce an arrhythmia if it did not respond to the electrical signals of the heart, but that doesn't appear to be happening."

In the remaining five rabbits, immune system inflammatory cells appear to have destroyed the injected muscle cells. Taylor said this is a natural response. The body sends immune system cel
'"/>

Contact: Karyn Hede George
George016@mc.duke.edu
919-684-4148
Duke University Medical Center
4-Aug-1998


Page: 1 2 3 4

Related biology news :

1. Transplanted stem cells restore function in stroke
2. Transplanted human stem cells develop into broad range of tissues, persist over a year in research at The Childrens Hospital of Philadelphia
3. Transplanted neural stem cells migrate throughout the abnormal brain, reduce disease symptoms
4. Skeletal Muscle Yields Precursors Of Bone Cells That Form Bone When Transplanted Into Animals
5. Three Institutions Combine Efforts In First-Ever Demonstration Of Long-Term Function In Transplanted Human Liver Cells
6. Transplanted Neurons Restore Function In Rats After Stroke
7. Muscles are smarter than you think
8. Muscle-derived cells and gene therapy may cure for post-prostatectomy erectile dysfunction
9. Muscle protein has role in nerve disorders
10. Muscle-repair defect underlies two muscular dystrophies
11. Muscle derived cell transplants offer alternative incontinence therapy says Pitt study

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/15/2018)... ... September 14, 2018 , ... The first ever production picosecond-domain laser with a ... and purple tattoo inks - often the colors most resistant to laser removal. , ... of the American Society for Laser Medicine and Surgery, Inc. (ASLMS) investigated the safety ...
(Date:9/12/2018)... ... September 11, 2018 , ... Tennant Coatings, ... the new ChemXP™ line of high performance secondary containment coatings, designed to protect ... provide Tennant Coatings’ elite certified installers with the needed solutions to protect facility’s ...
(Date:9/7/2018)... ... September 05, 2018 , ... Following ... manufacturing facility late last year, IPS-Integrated Project Services, LLC and G-CON Manufacturing have ... cell therapies. The iCON solution provides a pre-fabricated modular cleanroom infrastructure for the ...
Breaking Biology News(10 mins):
(Date:9/22/2018)... WESTMINSTER, Colo. (PRWEB) , ... ... ... Flagship Biosciences are excited to announce a strategic venture. The synergistic combination ... pathology platform provides complimentary and comprehensive biomarker profiling to empower clinical trials ...
(Date:9/13/2018)... , ... September 13, 2018 , ... Asymmetrex’s ... think we would have gotten in medicine, if we didn’t have the means to ... to treat patients?” His answer, “Nowhere! And that is what’s holding up progress ...
(Date:9/7/2018)... SANTA CLARA, Calif. (PRWEB) , ... September 05, 2018 , ... ... sponsored by Park Systems will be held on Sept. 19, 2018. With a panel ... trends on SPM, this exciting event will reveal industry insights from experts in the ...
(Date:9/1/2018)... ... 2018 , ... Rudina Thanasi, a scientifically validated holistic energy ... treated nutraceutical supplement used in combating inflammation and autoimmune disorders. , ... as, organ-specific inflammation. The reported data is as follows: , More than ...
Breaking Biology Technology:
Cached News: