HOME >> BIOLOGY >> NEWS
Transplanted Skeletal Muscle Mimics Heart Muscle; Helps Failing Heart Pump, Duke,,Researchers Say

e. For example, another new experimental procedure, called cardiomyoplasty, uses skeletal muscles taken from a patient's back or abdomen to wrap around an ailing heart. The muscle is stimulated by a device similar to a pacemaker to augment weak heart muscle. But, Taylor said, the skeletal muscle isn't really hooked up to the heart. It acts more like a mechanical assist device.

"Our idea is similar to earlier experiments by researchers at other universities who are trying to implant fetal muscle cells into hearts to stimulate growth," Taylor said. But, she added, that idea is not practical because there is no ready supply of fetal tissue and it could cause an immune reaction. The advantage of using muscle cells from each patient is that it's their own tissue, which won't be rejected by the immune system.

The Duke research team is testing the idea using rabbits, which have hearts very similar to a human heart. "Unlike some animals, rabbits have heart attacks just like people," Taylor said.

The researchers injected the damaged hearts of 12 rabbits with 10 million muscle cells. In seven of the 12, the cells took up residence and began stretching and contracting. In addition, when the researchers examined the hearts three to six weeks later, the skeletal muscle cells had organized themselves in a pattern resembling heart muscle cells, suggesting that the skeletal muscle had somehow "learned" how to act like heart muscle.

"We were very encouraged to see that the engrafted cells appear to adapt to their local environment and mimic heart muscle," Taylor said. "We had been concerned that the skeletal muscle could induce an arrhythmia if it did not respond to the electrical signals of the heart, but that doesn't appear to be happening."

In the remaining five rabbits, immune system inflammatory cells appear to have destroyed the injected muscle cells. Taylor said this is a natural response. The body sends immune system cel
'"/>

Contact: Karyn Hede George
George016@mc.duke.edu
919-684-4148
Duke University Medical Center
4-Aug-1998


Page: 1 2 3 4

Related biology news :

1. Transplanted stem cells restore function in stroke
2. Transplanted human stem cells develop into broad range of tissues, persist over a year in research at The Childrens Hospital of Philadelphia
3. Transplanted neural stem cells migrate throughout the abnormal brain, reduce disease symptoms
4. Skeletal Muscle Yields Precursors Of Bone Cells That Form Bone When Transplanted Into Animals
5. Three Institutions Combine Efforts In First-Ever Demonstration Of Long-Term Function In Transplanted Human Liver Cells
6. Transplanted Neurons Restore Function In Rats After Stroke
7. Muscles are smarter than you think
8. Muscle-derived cells and gene therapy may cure for post-prostatectomy erectile dysfunction
9. Muscle protein has role in nerve disorders
10. Muscle-repair defect underlies two muscular dystrophies
11. Muscle derived cell transplants offer alternative incontinence therapy says Pitt study

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... Research and Markets has announced the addition of the "Global ... ... at a CAGR of 30.37% during the period 2017-2021. ... based on an in-depth market analysis with inputs from industry experts. ... the coming years. The report also includes a discussion of the ...
(Date:4/6/2017)... Forecasts by Product Type (EAC), ... End-Use (Transportation & Logistics, Government & Public Sector, Utilities ... Generation Facility, Nuclear Power), Industrial, Retail, Business Organisation (BFSI), ... you looking for a definitive report on the $27.9bn ... ...
(Date:4/5/2017)... , April 4, 2017 KEY FINDINGS ... to expand at a CAGR of 25.76% during the ... is the primary factor for the growth of the ... https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global stem ... technology, application, and geography. The stem cell market of ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... LINDA, CA (PRWEB) , ... October 11, 2017 ... ... to upregulate any gene in its endogenous context, enabling overexpression experiments and avoiding ... (CRISPRa) system with small RNA guides is transformative for performing systematic gain-of-function studies. ...
(Date:10/11/2017)... HILLS, Calif. , Oct. 11, 2017  SkylineDx today ... (ICR) and University of Leeds ... risk-stratify patients with multiple myeloma (MM), in a multi-centric Phase ... University of Leeds is the sponsor ... and ICR will perform the testing services to include high-risk ...
(Date:10/10/2017)... Angeles, CA (PRWEB) , ... ... ... Inc., a development-stage cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, ... uses of targeted HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in ...
(Date:10/10/2017)... ... October 10, 2017 , ... USDM Life Sciences , ... life sciences and healthcare industries, announces a presentation by Subbu Viswanathan and Jennifer ... “Automating GxP Validation for Agile Cloud Platforms,” will present a revolutionary approach to ...
Breaking Biology Technology:
Cached News: