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Transplanted Skeletal Muscle Mimics Heart Muscle; Helps Failing Heart Pump, Duke,,Researchers Say

ls to the heart to clear out dead heart cells, and in this case they also cleared out the injected cells. She says that in the future, they will wait longer, until the body's normal inflammatory response subsides after the initial heart attack, before injecting the skeletal muscle cells. When the procedure is tried on people, doctors may also use anti-inflammatory agents to help give the skeletal muscle time to engraft, she said.

The researchers also plan to combine their work with findings reported in February by Dr. Thomas-Joseph Stegmann and his colleagues of Fulda Medical Center in Fulda, Germany. These researchers were able to induce damaged heart muscle to regenerate new blood vessels using a human growth factor called fibroblast growth factor 1 (FGF 1) that they produced with genetic engineering techniques.

"If we could combine new blood vessel formation with new muscle formation, we could for the first time, regenerate living heart muscle where there was only dead tissue," Taylor said.


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Contact: Karyn Hede George
George016@mc.duke.edu
919-684-4148
Duke University Medical Center
4-Aug-1998


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