HOME >> BIOLOGY >> NEWS
Treating precancerous breast cells may prevent onset of cancer

Boston, MA (October 17, 2002) Treating precancerous breast cells with chemopreventive agents, such as tamoxifen, limits the development of breast cancer in genetically predisposed women, according to a study presented at the American Association for Cancer Research's (AACR) annual Frontiers in Cancer Prevention meeting. Precancerous breast cells may also provide an effective mechanism for screening new and current chemopreventive agents.

The study used precancerous breast cells from patients with Li-Fraumeni syndrome (LFS), a hereditary cancer predisposition syndrome associated with a number of childhood cancers and the early onset of breast cancer. Unlike most human cancer cells, LFS cells become cancerous at more measurable rates in vitro (a closed environment, e.g. test tube), and are therefore easier to monitor. Individuals with LFS are at increased risk for developing multiple primary cancers, including soft-tissue sarcoma, breast cancer, leukemia, osteosarcoma, melanoma and colorectal cancers.

"To effectively treat or prevent cancer, it is important to understand the nature of how cells progress into the disease," explained Brittney-Shea Herbert, Ph.D., cell biologist at The University of Texas Southwestern Medical Center, Dallas, and lead investigator of the study. "Results from human clinical trials take many years to generate so it is imperative that alternate testing forms, such as precancerous cells, be used to determine the effectiveness of precancerous agents."

Treatment of precancerous LFS breast cells with some but not all chemopreventive agents decreased the development of cancer in vitro. The chemopreventive agents used in this study did not negatively affect normal cell growth, nor result in notable side effects from the treatment. Tamoxifen had the strongest effect in preventing the frequency of cell immortalization, at nontoxic levels.

Precancerous cells were treated with tolerable levels of tamoxifen,
'"/>

Contact: Aimee Frank
AMF@spectrumscience.com
202-369-1654
American Association for Cancer Research
17-Oct-2002


Page: 1 2

Related biology news :

1. Treating strokes with blood cord cells holds promise, Saint Louis University rat study shows
2. Treating bacterial infections can help asthmatics
3. Treating metastatic disease with a modified herpesvirus
4. Treating acne with antibiotics leads to resistance
5. Study Provides Guidance For Treating Patients With Brain Aneurysms
6. Relapses Prevented In Mouse Model Of Multiple Sclerosis: Research Aimed At Treating Relapses In Human MS
7. Mechanism Of Protein Folding Unraveled, With Eventual Implications For Treating Diseases Caused By Folding Errors
8. Gene Therapy In A Liquid May Lead To Quicker, Easier Methods For Treating Disease
9. New Class Of Protease Inhibitors May Be Effective In Treating One Of Latin Americas Most Devastating Diseases
10. Study Finds Shorter Period Of Drug Therapy Is Effective In Treating Stomach Ulcers Caused By H. Pylori
11. Treating Anemia Reduces Risk Of Death For People With HIV

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Treating precancerous breast cells may prevent onset cancer

(Date:4/14/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... the growing mobile commerce market, announces that its Wocket® ... York Design Awards under the category  ,Product Design – ... Awards are part of a global multi-disciplinary awards program. ... the marketplace, industry and judging panel. Winners will be ...
(Date:4/13/2015)... a leading cloud-based consumer engagement platform that provides trusted ... communities around health and wellness, announced today the launching ... The ... vehicle to receive validated health information from consumers. ... will allow higi,s trusted partners, on a user opt-in ...
(Date:4/9/2015)... , April 9, 2015 Synaptics Inc. (NASDAQ: ... solutions, announced today that it will report financial results ... April 23, 2015, after the close of market. The ... and investors at 2:00 p.m. PT (5:00 p.m. ET), ... To participate on the live call, analysts and ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3Synaptics to Report Third Quarter Results on April 23 2
(Date:4/21/2015)... ENGLEWOOD, Colo. , April 21, 2015 ... details for a scheduled investor call on Thursday, April ... in using the instructions as follows: ... toll-free number: (844) 789-4877 International toll number: (925) ... emailed in advance to Tina Amirkiai , ...
(Date:4/21/2015)... , April 21, 2015  Tute Genomics, a leading ... of Josh Forsythe as VP of Marketing. Mr. ... witnessed a significant expansion in its commercial operations over the ... " Josh Forsythe is a tremendous addition ... MD MBA, CEO of Tute Genomics. "Josh,s vast experience commercializing ...
(Date:4/21/2015)... April 21, 2015 PRC Clinical, ... and exhibit at the ACRP 2015 Global Conference and ... Utah. The Association of Clinical Research Professionals (ACRP) Global ... conference solely focused on the conduct of clinical trials. ... development, and widely recognized industry certifications. , The ...
(Date:4/21/2015)... Cleveleys (UK) (PRWEB) April 21, 2015 ... technology and its clinical applications will be ... Participants include engineers, scientists, regulators and clinicians ... The meeting is sponsored by Invibio Biomaterial ... polymer-based biomaterials, a specialist in manufacturing and ...
Breaking Biology Technology:Ampio Announces Investor Call on Thursday, April 23, 4:30 p.m. ET 2Tute Genomics Continues Expansion of Genomic Medicine Commercial Operations; Appoints Josh Forsythe as New VP of Marketing 2Tute Genomics Continues Expansion of Genomic Medicine Commercial Operations; Appoints Josh Forsythe as New VP of Marketing 3Tute Genomics Continues Expansion of Genomic Medicine Commercial Operations; Appoints Josh Forsythe as New VP of Marketing 4PRC Clinical Sponsors The ACRP 2015 Global Conference And Meets Biotech Companies in the Salt Lake City Area. 22nd International PEEK Meeting: Invibio Biomaterial Solutions spearheads medical research for implantable PEEK polymer devices 22nd International PEEK Meeting: Invibio Biomaterial Solutions spearheads medical research for implantable PEEK polymer devices 3
Cached News: