HOME >> BIOLOGY >> NEWS
Treatment in mice proves effective against Duchenne muscular dystrophy

CHAMPAIGN, Ill. Mice carrying the same gene deficiencies as humans with Duchenne muscular dystrophy experienced dramatic improvements in both their physical condition and life span following an experimental treatment by researchers at the University of Illinois.

By enhancing the production of a naturally occurring molecule on muscle tissue, the scientists reduced muscle-related problems and increased by three-fold the lifetimes of affected mice. Their work appears in the March 19 issue of the Journal of Cell Biology.

The work suggests that a gene therapy or a pharmaceutical approach targeting the molecule may be possible for human treatment, said Stephen J. Kaufman, a professor of cell and structural biology and of the College of Medicine. "The implications are that you could do gene therapy with an integrin chain to treat a muscular dystrophy thats caused by a membrane protein deficiency," he said. "Or you could chemically stimulate integrin chain production from the patients existing integrin chain genes."

Kaufmans lab discovered the molecule in question the alpha 7 integrin in 1985. A deficiency of this molecule exists in several forms of congenital muscular dystrophy. Conversely, Kaufman and his colleagues found that more of the integrin is present in Duchenne patients. These patients fail to produce another protein, dystrophin, which muscles also require for structural and functional integrity.

This discovery led to the idea that excess integrin may compensate for the lack of dystrophin and another similar protein, utrophin. To test their hypothesis, Kaufmans team used mice that did not produce dystrophin or utrophin, and they engineered them to produce even more of the alpha 7 integrin protein. Untreated mice developed debilitating muscular dystrophy, suffered severe weight loss and 50 percent died before reaching 12 weeks of age. Mice with enhanced alpha integrin production did not suffer severe muscular problems, maintained good m
'"/>

Contact: Jim Barlow
b-james3@uiuc.edu
217-333-5802
University of Illinois at Urbana-Champaign
18-Mar-2001


Page: 1 2

Related biology news :

1. St. Petersburg/New Haven Partnership for HIV/AIDS Care, Treatment and Support launched
2. Treatment stimulates growth and regeneration of injured adult skeletal muscle
3. Treatment of lupus in mice may point the way to human treatment
4. Treatment protects mouse ovaries from radiation therapy
5. National Institute on Drug Abuse launches National Drug Addiction Treatment Clinical Trials Network
6. Treatment restores normal heart rhythm in patients
7. Researchers Develop New Treatment For Hepatitis B And C As Nation Anticipates Surge In Number Of Cases
8. Researchers: Exciting Discovery Might Improve Cancer Treatment
9. Coffee Without Addiction, Possible New Treatment For Osteoporosis, Wrinkle-Free Cotton, And More
10. Scientists Discover Molecular Trigger Of Mucus Production, Suggesting First Treatment For Deadly Bronchitis, Other Diseases
11. Wistar Scientists Define Mechanism Of Action Used By Potential Magic Bullet In Cancer Treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/1/2018)... ... August 01, 2018 , ... RURO, Inc., a ... version 7.1. Limfinity® is the software framework that all of RURO’s products are ... both current users and the future of RURO’s laboratory software portfolio. , To ...
(Date:8/1/2018)... ... 2018 , ... Visikol CEO Dr. Michael Johnson has announced that through the ... Visikol will far exceed its original 2018 revenue projections. , Over the last ... pathology tools, whole mount imaging techniques and advanced 3D cell ...
(Date:7/31/2018)... ... July 31, 2018 , ... ... Muzek as Business Development Manager. In this role, Mr. Muzek will lead the ... Lifecycle’s continued growth and expansion. , With over 20 years in business ...
Breaking Biology News(10 mins):
(Date:8/9/2018)... ... August 08, 2018 , ... ActX ... and is continually updated by a talented scientific team that includes geneticists, PharmD’s, ... , 1. Information on the medical impact of a patient’s genetic variants ...
(Date:8/9/2018)... ... August 09, 2018 , ... ... Rockland, and Dr. Birte Aggeler, Director of Antibody Development at Bio-Techne, composed a ... article was published online on August 9, 2018 and will be printed in ...
(Date:8/1/2018)... (PRWEB) , ... August 01, ... ... healer, today announces research results on the significant impact of a proprietary ... responses. , The preclinical research assessed biomarkers for systemic and organ-specific ...
(Date:7/27/2018)... ... July 27, 2018 , ... ... Advocacy Group (BRAG®) and representatives of the Biotechnology Innovation Organization (BIO) met ... recently-issued white paper, “Proposal for a Toxic Substances Control Act (TSCA) Inventory ...
Breaking Biology Technology:
Cached News: