HOME >> BIOLOGY >> NEWS
Treatment of lupus in mice may point the way to human treatment

that patients with lupus may have variation in gene expression. They said they demonstrated that TSA and SAHA "can target expression of disease-modifying genes without affecting the expression of other genes."

Furthermore, the researchers said, since the two compounds reduced kidney disease in mice with systemic lupus, that might indicate a potential use as drugs for people with lupus.

The investigators cautioned that lupus in mice is not the same as lupus in people. For one thing, male and female mice are almost equally affected with the disease, compared to a 9 to 1 ratio of women over men. The pattern of symptoms in systemic lupus in people "is greater and the outcomes more variable" compared to the almost uniform progression of the disease in mice.

"These disease differences emphasize that the positive effects of TSA treatment in mice do no necessarily mean it will be effective in human lupus," Mishra said.

SAHA is available for testing because of studies indicating that it suppresses the growth of prostate cancer; THA has potent antitumor activity in breast cancer.

"Investigation of the potential role of these agents in autoimmune diseases are just beginning," said Mishra.

He said that Christopher M. Reilly of the Medical University of South Carolina, a member of the laboratory of Gary S. Gilkerson M.D., contributed equally to the experiments.


'"/>

Contact: Robert Conn, Karen Richardson or Barbara Hahn
rconn@wfubmc.edu
336-716-4587
Wake Forest University Baptist Medical Center
15-Feb-2003


Page: 1 2

Related biology news :

1. St. Petersburg/New Haven Partnership for HIV/AIDS Care, Treatment and Support launched
2. Treatment stimulates growth and regeneration of injured adult skeletal muscle
3. Treatment in mice proves effective against Duchenne muscular dystrophy
4. Treatment protects mouse ovaries from radiation therapy
5. National Institute on Drug Abuse launches National Drug Addiction Treatment Clinical Trials Network
6. Treatment restores normal heart rhythm in patients
7. Researchers Develop New Treatment For Hepatitis B And C As Nation Anticipates Surge In Number Of Cases
8. Researchers: Exciting Discovery Might Improve Cancer Treatment
9. Coffee Without Addiction, Possible New Treatment For Osteoporosis, Wrinkle-Free Cotton, And More
10. Scientists Discover Molecular Trigger Of Mucus Production, Suggesting First Treatment For Deadly Bronchitis, Other Diseases
11. Wistar Scientists Define Mechanism Of Action Used By Potential Magic Bullet In Cancer Treatment

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Treatment lupus mice may point the way human treatment

(Date:7/21/2015)...  NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... on the growing mobile commerce market and creator ... has filed provisional patent 62/192218 for ... This invention highlights next generation payment technology from ... also the user using unique personal identifiers including ...
(Date:7/20/2015)... July 20, 2015  Acuity Market Intelligence,s latest ... Convergence of Commerce and Privacy" forecasts that between ... apps will be downloaded to smart mobile devices ... biometrics market is projected to generate more than ... the seven-year forecast period.    "Biometrics ...
(Date:7/13/2015)... Conn. , Jul. 13, 2015 NXT-ID, ... "Company"), a biometric authentication company focused on the ... has filed provisional patent 62/188684 for ... achieves another new convenient and secure method to ... new, innovative payment methods, introduced with its groundbreaking ...
Breaking Biology News(10 mins):NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 2NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 3NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 4Biometrics on Smart Mobile Devices to Redefine Digital Identity with 12.9 Billion Biometric App Downloads between 2014 and 2020 2NXT-ID Patents Behavior-Directed Payments 2NXT-ID Patents Behavior-Directed Payments 3NXT-ID Patents Behavior-Directed Payments 4
(Date:7/28/2015)... 2015  PDL BioPharma, Inc. (PDL, or the Company) ... will release its second quarter 2015 financial results for ... 5, 2015, after market close. PDL,s management will host ... p.m. Eastern Time to discuss the financial results.  A ... via the webcast link on the PDL website. ...
(Date:7/28/2015)... ... 2015 , ... In terms of value, aluminium hydroxide production ... reached close to 1.84 million tonnes in the same year. As of 2013, ... region’s total aluminium hydroxide production; the country’s aluminium hydroxide production posted a 101.8% ...
(Date:7/28/2015)... ... July 28, 2015 , ... VetStem Biopharma will be offering weekly private ... to local area veterinarians. , The tour and course will be given every Wednesday ... at VetStem’s Poway facility. Staff members are welcome to attend with their veterinarian as ...
(Date:7/28/2015)... 28, 2015  Kerastem Technologies announce that the Company ... FDA Center For Biologics Evaluation and Research (CBER) Office ... clinical trial investigating the safety and feasibility of the ... male pattern baldness (androgenic alopecia). The phase ... clinical work in Europe and ...
Breaking Biology Technology:PDL BioPharma to Announce Second Quarter 2015 Financial Results on August 5, 2015 2EU27 Aluminium Hydroxide Market Analysed and Forecast by BAC Reports in New Research Study Available at MarketPublishers.com 2EU27 Aluminium Hydroxide Market Analysed and Forecast by BAC Reports in New Research Study Available at MarketPublishers.com 3VetStem Biopharma weekly veterinary continuing education classes and GMP manufacturing facility tour 2Kerastem Receives Conditional Approval from FDA for Alopecia Trial 2
Cached News: