HOME >> BIOLOGY >> NEWS
Treatment of lupus in mice may point the way to human treatment

that patients with lupus may have variation in gene expression. They said they demonstrated that TSA and SAHA "can target expression of disease-modifying genes without affecting the expression of other genes."

Furthermore, the researchers said, since the two compounds reduced kidney disease in mice with systemic lupus, that might indicate a potential use as drugs for people with lupus.

The investigators cautioned that lupus in mice is not the same as lupus in people. For one thing, male and female mice are almost equally affected with the disease, compared to a 9 to 1 ratio of women over men. The pattern of symptoms in systemic lupus in people "is greater and the outcomes more variable" compared to the almost uniform progression of the disease in mice.

"These disease differences emphasize that the positive effects of TSA treatment in mice do no necessarily mean it will be effective in human lupus," Mishra said.

SAHA is available for testing because of studies indicating that it suppresses the growth of prostate cancer; THA has potent antitumor activity in breast cancer.

"Investigation of the potential role of these agents in autoimmune diseases are just beginning," said Mishra.

He said that Christopher M. Reilly of the Medical University of South Carolina, a member of the laboratory of Gary S. Gilkerson M.D., contributed equally to the experiments.


'"/>

Contact: Robert Conn, Karen Richardson or Barbara Hahn
rconn@wfubmc.edu
336-716-4587
Wake Forest University Baptist Medical Center
15-Feb-2003


Page: 1 2

Related biology news :

1. St. Petersburg/New Haven Partnership for HIV/AIDS Care, Treatment and Support launched
2. Treatment stimulates growth and regeneration of injured adult skeletal muscle
3. Treatment in mice proves effective against Duchenne muscular dystrophy
4. Treatment protects mouse ovaries from radiation therapy
5. National Institute on Drug Abuse launches National Drug Addiction Treatment Clinical Trials Network
6. Treatment restores normal heart rhythm in patients
7. Researchers Develop New Treatment For Hepatitis B And C As Nation Anticipates Surge In Number Of Cases
8. Researchers: Exciting Discovery Might Improve Cancer Treatment
9. Coffee Without Addiction, Possible New Treatment For Osteoporosis, Wrinkle-Free Cotton, And More
10. Scientists Discover Molecular Trigger Of Mucus Production, Suggesting First Treatment For Deadly Bronchitis, Other Diseases
11. Wistar Scientists Define Mechanism Of Action Used By Potential Magic Bullet In Cancer Treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/6/2017)... Forecasts by Product Type (EAC), Biometrics, Card-Based ... & Logistics, Government & Public Sector, Utilities / Energy ... Nuclear Power), Industrial, Retail, Business Organisation (BFSI), Hospitality & ... for a definitive report on the $27.9bn Access Control ... ...
(Date:4/3/2017)... 3, 2017  Data captured by IsoCode, ... detected a statistically significant association between the ... treatment and objective response of cancer patients ... predict whether cancer patients will respond to ... well as to improve both pre-infusion potency testing ...
(Date:3/28/2017)... PUNE, India , March 28, 2017 ... (Analog, IP, Biometrics), Hardware (Camera, Monitors, Servers, Storage Devices), ... Maintenance), Vertical, and Region - Global Forecast to 2022", ... 30.37 Billion in 2016 and is projected to reach ... 15.4% between 2017 and 2022. The base year considered ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... 10, 2017 SomaGenics announced the receipt of ... develop RealSeq®-SC (Single Cell), expected to be the first ... (including microRNAs) from single cells using NGS methods. The ... to accelerate development of approaches to analyze the heterogeneity ... "New techniques for measuring levels of mRNAs in individual ...
(Date:10/10/2017)... ... October 10, 2017 , ... The Pittcon Program Committee is ... honoring scientists who have made outstanding contributions to analytical chemistry and applied spectroscopy. ... world’s leading conference and exposition for laboratory science, which will be held February ...
(Date:10/9/2017)... ... October 09, 2017 , ... The award-winning American Farmer television series will feature ... Farmer airs Tuesdays at 8:30aET on RFD-TV. , With global population estimates nearing ... how to continue to feed a growing nation. At the same time, many of ...
(Date:10/9/2017)... ... October 09, 2017 , ... ... line of medical marijuana products targeting the needs of consumers who are incorporating ... Kindred takes place in Phoenix, Arizona. , As operators of two successful Valley ...
Breaking Biology Technology:
Cached News: