Treatment of lupus in mice may point the way to human treatment

that patients with lupus may have variation in gene expression. They said they demonstrated that TSA and SAHA "can target expression of disease-modifying genes without affecting the expression of other genes."

Furthermore, the researchers said, since the two compounds reduced kidney disease in mice with systemic lupus, that might indicate a potential use as drugs for people with lupus.

The investigators cautioned that lupus in mice is not the same as lupus in people. For one thing, male and female mice are almost equally affected with the disease, compared to a 9 to 1 ratio of women over men. The pattern of symptoms in systemic lupus in people "is greater and the outcomes more variable" compared to the almost uniform progression of the disease in mice.

"These disease differences emphasize that the positive effects of TSA treatment in mice do no necessarily mean it will be effective in human lupus," Mishra said.

SAHA is available for testing because of studies indicating that it suppresses the growth of prostate cancer; THA has potent antitumor activity in breast cancer.

"Investigation of the potential role of these agents in autoimmune diseases are just beginning," said Mishra.

He said that Christopher M. Reilly of the Medical University of South Carolina, a member of the laboratory of Gary S. Gilkerson M.D., contributed equally to the experiments.


Contact: Robert Conn, Karen Richardson or Barbara Hahn
Wake Forest University Baptist Medical Center

Page: 1 2

Related biology news :

1. St. Petersburg/New Haven Partnership for HIV/AIDS Care, Treatment and Support launched
2. Treatment stimulates growth and regeneration of injured adult skeletal muscle
3. Treatment in mice proves effective against Duchenne muscular dystrophy
4. Treatment protects mouse ovaries from radiation therapy
5. National Institute on Drug Abuse launches National Drug Addiction Treatment Clinical Trials Network
6. Treatment restores normal heart rhythm in patients
7. Researchers Develop New Treatment For Hepatitis B And C As Nation Anticipates Surge In Number Of Cases
8. Researchers: Exciting Discovery Might Improve Cancer Treatment
9. Coffee Without Addiction, Possible New Treatment For Osteoporosis, Wrinkle-Free Cotton, And More
10. Scientists Discover Molecular Trigger Of Mucus Production, Suggesting First Treatment For Deadly Bronchitis, Other Diseases
11. Wistar Scientists Define Mechanism Of Action Used By Potential Magic Bullet In Cancer Treatment

Post Your Comments:
TAG: Treatment lupus mice may point the way human treatment

(Date:9/24/2015)... Publiceringsförbud fram till: ... Kerv ( http://kerv.com ), det Londonbaserade ... första kontaktlösa betalningsring på kickstarter.com i ett ... för massproduktion via crowdfunding.       ... Kerv-bärare kan göra direkta kontaktlösa betalningar ...
(Date:9/10/2015)... Sept. 10, 2015 Pursuant Health has ... to create an interactive, image-based health risk assessment ... wellness kiosk.  The unique assessment quantifies user results ... that suggests an individual,s biological age based on ... measured by the kiosk. Comprised of ...
(Date:9/8/2015)... , Sept. 8, 2015  Affectiva, global ... Emotion as a Service, a new data solution, ... Based on Affectiva,s highly accurate and patented ... analytics capabilities, slated to transform industries such as ... development, retail, customer experience, online education, HR, automotive, ...
Breaking Biology News(10 mins):
(Date:10/9/2015)... Governor Tom Wolf announced today that Adaptimmune ... T-cell receptor cancer immunotherapy treatments, will create at least ... Pennsylvania , and today,s announcement ... high-paying jobs will be created with this project," said ... sustained funding for the life science sector and increased ...
(Date:10/9/2015)... Oct. 9, 2015  DePuy Synthes Trauma* announced today ... Q-PACK ®  Technology**, the only pre-hydrated demineralized cancellous ... procedures (foot and ankle, hand and wrist), including fusion, ... here at the 2015 Orthopaedic Trauma Association (OTA) Annual ... scaffold for new bone growth) and osteoinductive 2,3 ...
(Date:10/9/2015)... ... October 09, 2015 , ... ... the current methods of separating those cells from their surroundings for research, diagnostics, ... the cells. , To address this, Ann Arbor-based startup Akadeum Life Sciences ...
(Date:10/8/2015)... ... October 08, 2015 , ... Researchers at the University of Washington (UW) ... providing a new tool to study how diseases like dementia, Alzheimer's, and brain tumors ... and Ruikang Wang of the UW Department of Bioengineering, today in the Journal ...
Breaking Biology Technology:
Cached News: