HOME >> BIOLOGY >> NEWS
Treatment stimulates growth and regeneration of injured adult skeletal muscle

Scientists have discovered that a group of chemicals known as Histone Deacetylase (HDAC) inhibitors stimulate growth and regeneration of adult skeletal muscle cells by increasing expression of the protein follistatin. The research, published in the May issue of Developmental Cell, may provide new avenues for developing effective means to promote regeneration in muscular dystrophies.

Dr. Vittorio Sartorelli from the Muscle Gene Expression Group in the Laboratory of Muscle Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, in Bethesda, Maryland, and colleagues at the Salk Institute and the Dulbecco Telethon Institute in Rome report that HDAC inhibitors, which stimulate the formation of mature muscle cells from immature precursor cells, also cause a significant elevation of follistatin levels. When follistatin levels are reduced, then HDAC inhibitors no longer stimulate adult muscle growth. The regeneration activities of the HDAC inhibitors appear to function only in skeletal muscle, since follistatin is not stimulated in other cell types tested. In animal studies, administration of an HDAC inhibitor produced clear signs of muscle regeneration in regions of injured skeletal muscle tissues.

"Our findings establish for the first time that follistatin promotes the recruitment and fusion of immature muscle cells to pre-existing adult muscle fibers. These results suggest that follistatin is a promising target for future drug development of muscle regeneration. HDAC inhibitors, by stimulating follistatin, could well be pharmacologically useful as stimulants of muscle regeneration. We are investigating whether these inhibitors are a viable treatment to regenerate healthy new muscle tissues in animal models of muscular dystrophies," explains Dr. Sartorelli. The functional link between HDAC inhibitors, follistatin, and adult muscle regeneration is especially provocative as an HDAC inhibitor is already being used clinically in hu
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
10-May-2004


Page: 1 2

Related biology news :

1. St. Petersburg/New Haven Partnership for HIV/AIDS Care, Treatment and Support launched
2. Treatment of lupus in mice may point the way to human treatment
3. Treatment in mice proves effective against Duchenne muscular dystrophy
4. Treatment protects mouse ovaries from radiation therapy
5. National Institute on Drug Abuse launches National Drug Addiction Treatment Clinical Trials Network
6. Treatment restores normal heart rhythm in patients
7. Researchers Develop New Treatment For Hepatitis B And C As Nation Anticipates Surge In Number Of Cases
8. Researchers: Exciting Discovery Might Improve Cancer Treatment
9. Coffee Without Addiction, Possible New Treatment For Osteoporosis, Wrinkle-Free Cotton, And More
10. Scientists Discover Molecular Trigger Of Mucus Production, Suggesting First Treatment For Deadly Bronchitis, Other Diseases
11. Wistar Scientists Define Mechanism Of Action Used By Potential Magic Bullet In Cancer Treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/22/2020)... ... July 21, 2020 , ... USDM Life Sciences ... compliance, announces a new solution to manage regulated workloads on Microsoft Azure. , ... technology stack complies with FDA and global regulations. USDM's new managed service for ...
(Date:7/18/2020)... ... July 17, 2020 , ... Commercial launch readiness is a ... to discover a COVID cure or vaccine, the global economic downturn will only increase ... is not going away and capturing full value from every product launch is critical. ...
(Date:7/10/2020)... , ... July 09, 2020 , ... Today CJ BIO ... which will share insight on the “fifth taste” phenomenon that is revolutionizing ingredient mixes, ... Umami Advantage will be live on Monday, July 13, 2020 at11:00 AM (CDT) during ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... , ... August 11, 2020 ... ... biopharmaceutical cold chain validation engineering firm, is making available for free its ... need to incorporate concurrent transport simulation testing into today’s biologics licensing application ...
(Date:7/31/2020)... SCOTTSDALE, Ariz. (PRWEB) , ... July 29, 2020 , ... ... cell joint injections for only $3950. With 50 million stem cells total, patients may ... well stem cell therapy works for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 ...
(Date:7/31/2020)... ... ... eSource has long been touted as the solution to high data management and monitoring ... did not take off as quickly as people initially expected, and where eSource is ... data electronically for clinical trials and then repurposing it for downstream analysis, at a ...
(Date:7/18/2020)... ... ... “We are thrilled to deliver this new technology to the industry” said Matt ... the market and we were pleased that the IFT jury recognized that.” reFRESH™ couples ... a natural way to extend the shelf life and improve the safety of perishable ...
Breaking Biology Technology:
Cached News: