ested to see if it would deplete the activity of MGMT. Combined with this drug it was possible that temozolomide might also then become effective in patients with an unmethylated MGMT promoter, although it would be likely to increase toxicity to other organs as MGMT protected against DNA mutations. The research team is also analysing the trial biopsies for molecular patterns that might indicate possible new drug targets.

Temozolomide is the first chemotherapy for 30 years to have been proven effective for glioblastomas, which make up around 12 to 15% of all brain cancers with 2-3 new cases diagnosed per 100,000 population annually in Europe and North America[2]. The drug was approved in 1999 for use in patients who have relapsed after initial treatment.

"Our results should encourage and fuel further multidisciplinary research, bridging the gap between basic research and clinical practice," said Dr. Hegi. "Whether temozolomide will cure some patients remains to be demonstrated. Glioblastoma remains a dreadful disease without a cure, and there is still a long way to go."

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Contact: Margaret Willson
m.willson@mwcommunications.org.uk
41-227-612-205
European Organisation for Research and Treatment of Cancer
29-Sep-2004

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