Trojan Horse Virus Controls Hiv Infection

National Institute of Allergy and Infectious Diseases (NIAID) grantees at Yale University have converted a common livestock virus into a Trojan horse that selectively targets HIV-infected cells and then destroys them. As reported Sept. 5 in the journal Cell, this strategy effectively controlled HIV infection in laboratory-grown T cells and dramatically reduced infectious HIV to levels that were barely or no longer detectable.

"This is a completely new approach, targeting a virus to an infected cell," explains the study's senior scientist, John K. Rose, Ph.D., from Yale's Departments of Pathology and Cell Biology. "The concept could be used to develop a whole new class of agents that are useful for controlling disease."

"Although additional in vitro and animal studies need to be performed before this novel virus can be tested in humans," comments NIAID Director Anthony S. Fauci, M.D., "this concept of cell-targeted delivery has enormous potential applications for HIV, cancer or other diseases."

In their report, Dr. Rose, Matthias J. Schnell, Ph.D., and their colleagues describe how they modified the vesicular stomatitis virus (VSV) genome, deleting its envelope gene and replacing it with the genes for a pair of cell surface receptor -- CD4 and the coreceptor CXCR4 -- normally found on human T cells. These receptors enable HIV to attach to, enter and infect T cells.

These receptors also permit cell-to-cell HIV infection to occur. HIV-infected cells flag themselves for destruction by the body's immune system by displaying HIV's outer coat protein. But this protein, HIV gp120, is the same one that attaches to the T-cell receptors and leads to infection. Cell-to-cell infection occurs when the HIV gp120 on an infected cell first hitches up to the receptors on an uninfected T cell, resulting in the fusion of the cell and viral membranes, and transfer of virus from the infected to the uninfected cell.

Turning around what occurs naturally, the rem

Contact: Laurie K. Doepel
NIH/National Institute of Allergy and Infectious Diseases

Page: 1 2 3 4

Related biology news :

1. Trojan Horses, xenon imaging and remote controlled genes
2. Purdue corrals new Trojan horse to replace wayward genes in mice
3. Trojan horse technology destroys blood supply to cancer tumors in mice
4. Nanocircles act as Trojan horse to shut down disease-causing genes, study finds
5. Science: nanoscale Trojan Horse attacks cancer cells from within
6. Horse owners should vaccinate horses, experts say
7. Horseshoe crabs survival rate after biomedical bleeding is high
8. Horse breath testing to benefit racing
9. Horseshoe Crab Research Center provides information to improve management
10. Horseshoe crab studies providing new insight into valuable ancient creatures
11. Continuing Research On Knee Surgery For Horses At Colorado State University Holds Promise Of Helping Humans With Osteoarthritis

Post Your Comments:

(Date:8/21/2020)... ... 20, 2020 , ... NDA Partners Chairman Carl Peck, ... with expertise in clinical trial planning and feasibility, regulatory inspection readiness, and clinical ... his career, Mr. Movahhed has helped design and manage oncology, neurology, cardiovascular, and ...
(Date:8/12/2020)... (PRWEB) , ... August 12, 2020 , ... ... and monitoring systems that are ideal for public health agencies of all sizes. ... contagious diseases and helping at-risk individuals find appropriate health care, Mosio helps public ...
(Date:8/7/2020)... ... August 06, 2020 , ... ... the prestigious National STEM Scholar Program, a unique professional development program that provides ... support for middle school science teachers nationwide. , Created in partnership between the ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is now ... With 50 million stem cells total, patients may choose which extremities they would like ... arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is obtained ...
(Date:7/31/2020)... ... 2020 , ... Anomet Products has introduced new custom composite ... with CRM, neurostimulation, vascular, and related devices. , Anomet Medical Clad Wire ... and cost criteria; especially where solid wire is limited. Typical configurations for implantable ...
(Date:7/31/2020)... ... July 29, 2020 , ... The SDX® ... in 16 countries, has reached its 20th anniversary of worldwide use. Introduced in ... at top universities including University of Pennsylvania, University of Michigan, University of Maryland, ...
(Date:7/18/2020)... ... July 16, 2020 , ... After research model surgery and catheter implantation, ... surgery is only the beginning of a successful study, while protecting and accessing the ... Gien, Global Head of Surgery from Envigo in a live webinar ...
Breaking Biology Technology:
Cached News: