HOME >> BIOLOGY >> NEWS
Tumor Oxygen Level And Blood Flow Fluctuate, Duke Scientists Discover

PHILADELPHIA -- In a discovery that might help explain why widely used cancer therapies are less than optimal, Duke University Medical Center researchers have found that a tumor's oxygen level and blood flow can fluctuate rapidly. The Duke animal study, which contradicts previous assumptions about tumors, could be important because the two major cancer treatments, radiation and chemotherapy, depend on a constant high oxygen level and steady blood flow within a tumor, scientists said. "These fluctuations in oxygen level and blood flow are not predictable and might represent an impediment to radiation therapy and drug therapy," said Mark Dewhirst, co-director of the radiation oncology and hyperthermia program at Duke Comprehensive Cancer Center and associate professor of pathology. "Before this work, there was no way to reliably measure these values."

Dewhirst prepared the findings for presentation Tuesday at an American Association for Cancer Research meeting. His study, which was done in collaboration with Rod Braun, assistant professor in radiation oncology, was funded by the National Cancer Institute. A report based on the results of this study has been accepted for publication by the American Journal of Physiology. High oxygen levels are crucial for effective radiation therapy, Dewhirst explained, because radiation kills tumor cells by forming oxygen radicals -- highly reactive oxygen atoms that damage DNA.

Chemotherapy might be affected by the fluctuations, Dewhirst said, because if tumor blood flow drops, the drugs might not be delivered efficiently throughout the tumor.

While low oxygen levels, called hypoxia, are known to exist in certain tumors, researchers had not measured changes in oxygen levels over time. In the current study, Dewhirst and his colleagues measured oxygen levels in mammary tumors in seven rats using an electrochemical probe that produces an electrical current depending on the amount of oxygen present in the tissue.

T
'"/>

Contact: Joanna Downer
downe010@mc.duke.edu
919-684-4148
Duke University Medical Center
14-Apr-1999


Page: 1 2 3

Related biology news :

1. Tumor cell-specific therapy shows preclinical promise
2. Tumor cells made more sensitive to radiation by blocking a key cellular molecule
3. Discovery Of 13 Genes Expressed In Brain Tumors May Lead To More Effective Diagnosis Or Prevention
4. Dietary Lutein Inhibits Mammary Tumor Growth And Normalizes Immune Balance In Tumor-Bearing Mice
5. Vion Demonstrates Readiness Of First Tumor-Targeting Salmonella For Human Testing Against Solid Tumors
6. Compounds From Fruits, Vegetables And Grains Slow The Growth Of Human Tumor Cells
7. New Cell Isolation Method Will Aid In Studying Tumor Development
8. Wistar Institute To Host 3rd International Conference On Molecular And Clinical Genetics Of Childhood Renal Tumors And The Mitchell Ross Symposium
9. Scientists Study Proteins Role In Tumor Development In Fish
10. Fly Tumor Points Way To New Understanding Of Cancer Development
11. Vions TAPET Organisms Demonstrate Reduced Virulence, Increased Safety While Retaining Ability To Specifically Target Tumors

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/24/2020)... , ... January 24, 2020 , ... Worldwide Business ... President Dr. Stanley Stanbridge and Vice President of Sales and Marketing Jeff Maier ... Business Network as sponsored content on Sunday, Jan. 26, 2020 at 5:30 p.m. EST ...
(Date:1/23/2020)... ... , ... GIOSTAR/HEAMGEN has developed and secured patented ... red blood cells are made utilizing a bioreactor that permits the production of ... the need for a human blood donor. GIOSTAR/HEAMGEN mature red blood ...
(Date:1/22/2020)... MESA, Calif. (PRWEB) , ... January 21, 2020 ... ... of Robert Pozil to lead the company’s new Business Development Department. The move, ... 2019. Mr. Pozil had been previously serving as the company’s Senior Vice President ...
Breaking Biology News(10 mins):
(Date:1/22/2020)... ... January 20, 2020 , ... ... with WAVE Electronics, the largest independent electronics distributor in the US, to make ... Smart Home Systems with leading smart home products from a single fulfillment partner. ...
(Date:1/22/2020)... ... January 21, 2020 , ... ... the precision of Genome editing. The partners have agreed to co-develop and market ... CRISPR research, agricultural, and pre-clinical programs. Over the longer-term, the parties aim to ...
(Date:1/10/2020)... (PRWEB) , ... January 09, 2020 , ... ... of Drug Development establishes benchmarks for the vendor qualification process, a critical ... Report, the process volume and complexity of the vendor qualification process creates delays ...
(Date:1/10/2020)... ... January 09, 2020 , ... GenScript ... inaugural GenScript Biotech Global Forum on Jan. 14 in San Francisco, coinciding with ... Gene Therapy and the Booming China Market," will feature gene and cell therapy ...
Breaking Biology Technology:
Cached News: