HOME >> BIOLOGY >> NEWS
Tumor cells made more sensitive to radiation by blocking a key cellular molecule

breaking down another molecule, IkappaB. This molecule is attached to NF-kappaB and blocks it from activating. Much like a car's brakes, IkappaB stops NF-kappaB from moving into the nucleus, the cell's master control room.

The researchers also studied the effects of infusing tumor cells with a type of IkappaB that is a super-repressor of NF-kappaB. This super-repressor molecule when ferried into tumor cells via an inactivated cold virus creates a very stable attachment to NF-kappaB.

"We were able to determine that NF-kappaB inhibition by either method did in fact produce increased cell killing after radiation," Tepper said. "And we could document both increased cell killing and increased apoptosis."

Moreover, both Tepper and Russo point out that they also documented a decrease in "clonogenic survival." After treatment, tumor cells eventually ceased to divide and died. "This is the most important endpoint," Tepper said.

"We found that treatment with IkappaB super-repressor or PS-341 increased the radiation response," Russo said. "And when we went in vivo to look at mouse models and did the same interventions with tumors we grew on mice, we found the same thing.

"Potentially, agents that modify programmed cell death are exciting in that they may enhance the effects of our current anti-tumor therapies. As demonstrated by this study, radiation may work better in the presence of one of these agents."


'"/>

Contact: Leslie H. Lang
LLANG@MED.UNC.EDU
919-843-9687
University of North Carolina School of Medicine
24-Oct-2000


Page: 1 2

Related biology news :

1. Tumor cell-specific therapy shows preclinical promise
2. Discovery Of 13 Genes Expressed In Brain Tumors May Lead To More Effective Diagnosis Or Prevention
3. Dietary Lutein Inhibits Mammary Tumor Growth And Normalizes Immune Balance In Tumor-Bearing Mice
4. Tumor Oxygen Level And Blood Flow Fluctuate, Duke Scientists Discover
5. Vion Demonstrates Readiness Of First Tumor-Targeting Salmonella For Human Testing Against Solid Tumors
6. Compounds From Fruits, Vegetables And Grains Slow The Growth Of Human Tumor Cells
7. New Cell Isolation Method Will Aid In Studying Tumor Development
8. Wistar Institute To Host 3rd International Conference On Molecular And Clinical Genetics Of Childhood Renal Tumors And The Mitchell Ross Symposium
9. Scientists Study Proteins Role In Tumor Development In Fish
10. Fly Tumor Points Way To New Understanding Of Cancer Development
11. Vions TAPET Organisms Demonstrate Reduced Virulence, Increased Safety While Retaining Ability To Specifically Target Tumors

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2017)... , March 30, 2017 Trends, opportunities ... (physiological and behavioral), by technology (fingerprint, AFIS, iris recognition, ... recognition, and others), by end use industry (government and ... immigration, financial and banking, and others), and by region ... , Asia Pacific , and ...
(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
(Date:3/24/2017)... March 24, 2017 The Controller General of Immigration ... Abdulla Algeen have received the prestigious international IAIR Award for ... Continue Reading ... ... Deputy Controller Abdulla Algeen (small picture on the right) have received the ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... 9, 2017  BioTech Holdings announced today identification ... its ProCell stem cell therapy prevents limb loss ... Company, demonstrated that treatment with ProCell resulted in ... as compared to standard bone marrow stem cell ... in reduction of therapeutic effect.  ...
(Date:10/9/2017)... ... October 09, 2017 , ... ... line of medical marijuana products targeting the needs of consumers who are incorporating ... Kindred takes place in Phoenix, Arizona. , As operators of two successful Valley ...
(Date:10/7/2017)... Seattle, WA (PRWEB) , ... ... ... the industry leader in Hi-C-based genomic technologies, launched its ProxiMeta™ Hi-C metagenome ... the ProxiMeta Hi-C kit and accompanying cloud-based bioinformatics software to perform Hi-C ...
(Date:10/6/2017)... (PRWEB) , ... October 06, 2017 , ... ... host a lunch discussion and webinar on INSIGhT, the first-ever adaptive clinical trial ... Investigator, Dana-Farber Cancer Institute. The event is free and open to the public, ...
Breaking Biology Technology:
Cached News: