HOME >> BIOLOGY >> NEWS
Turning blood into brain: new studies suggest bone marrow stem cells can develop into neurons in living animals

For years, researchers studying stem cells have been intrigued by the possibility that these cells might be used to treat brain diseases. Recent studies have suggested that neural stem cells transplanted into the brain can migrate throughout the brain and develop into other types of cells. Now, two new studies show that bone marrow cells transplanted into mice can migrate into the brain and develop into cells that appear to be neurons. The studies suggest that bone marrow may be a readily available source of neural cells with potential for treating such neurological disorders as Parkinsons disease and traumatic brain injury.

While previous research has shown that bone marrow cells can develop into neuron-like cells in culture, the new studies are the first to show that this process can also happen in living animals. The two studies reached the same conclusion despite many differences in how the studies were performed. The results are reported in the December 1, 2000, issue of Science.

"These are extraordinarily important studies, carefully done, with clear implications for brain disorders and for basic developmental biology," says Gerald D. Fischbach, M.D., director of the National Institute of Neurological Disorders and Stroke (NINDS).

In the first study,(1) NINDS investigator va Mezey, M.D., Ph.D., and colleagues injected bone marrow cells from normal male mice into newborn female mice that had no white blood cells of their own. Using marrow from male mice allowed the researchers to use the Y chromosomes in the transplanted cells as a marker to distinguish them from native cells. At different time intervals, the researchers examined cells from the brains of seven mice that had received the transplants and compared them to littermates that had not received the transplants. By 4 months after the transplants, they found a significant number of neuronal cells in several brain regions, including the cortex, the hypothalamus, and the str
'"/>

Contact: Natalie Frazin or Margo Warren
301-496-5751
NIH/National Institute of Neurological Disorders and Stroke
29-Nov-2000


Page: 1 2 3

Related biology news :

1. Turning bone into nerve
2. Turning foe into friend with lentiviral vectors
3. Turning off building lights reduces bird window-kill by 83%
4. Turning salt and water into wine
5. Turning down the Sun
6. UNC Researchers Reduce Arthritis Severity By Turning Off Molecular Switch
7. Turning "Unrecyclable" Waste Into Plastic Products
8. Survey Shows Students Turning To Physicians Less As Drug Abuse Increases
9. Africa At The Turning Point
10. Nitric Oxide Found To Control Cells By Turning On Genes; Suggests New Role In Health And Disease
11. Experimental drug shown to block mutant protein causing blood disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/28/2020)... , ... May 28, 2020 , ... ... that interim results from their 1801 Phase 1/2 study (NCT03678883, EudraCT #: 2018-003739-32) ... Meeting which will take place virtually on May 29th, 2020. Dr. Benedito Carneiro, ...
(Date:5/21/2020)... ... May 21, 2020 , ... ... specializing in background and medical screening, announces the launch of a testing ... their workforce safe. The new service is provided by ClearStar’s Medical Information ...
(Date:5/21/2020)... SCOTTSDALE, Ariz. (PRWEB) , ... May 20, 2020 , ... ... justice, and remove danger for all of us. The positions of these men and ... as from the defense for not following rules precisely. Officers have always had to ...
Breaking Biology News(10 mins):
(Date:7/7/2020)... ... July 06, 2020 , ... R3 International is now ... up to 200 million stem cells. Depending on the patient's condition, treatment may be ... US will die having some form of Alzheimers dementia, and the incidence continues to ...
(Date:7/1/2020)... CHARLOTTE, N.C. (PRWEB) , ... June 29, 2020 ... ... has reported year to date growth of 40% in 2020, despite many obstacles ... medical technology, MedShift aims to increase revenue for its partnered medical practices and ...
(Date:7/1/2020)... ... June 30, 2020 , ... ... insights, today announced that the launch of a new clinical diagnostics ... about the tumor microenvironment (TME). , “Flagship’s TissueInsight is a service that ...
(Date:6/28/2020)... ... June 25, 2020 , ... ... develop a vaccine or drug treatment. In an effort to better understand the ... released the world’s largest imaging dataset portraying therapeutic compound effects from over 1,600 ...
Breaking Biology Technology:
Cached News: