HOME >> BIOLOGY >> NEWS
Two genes may interact to increase risk of lung cancer in smokers

WASHINGTON, July 13 Researchers have long sought to explain why some smokers get lung cancer and others do not. In one of the first studies to suggest that the interaction of two genes may play a role, researchers at the University of Pittsburgh Cancer Institute (UPCI) have found that inheriting alterations in both a DNA repair gene and a cyclin D1 gene may increase the risk of lung cancer in those exposed to tobacco carcinogens. The preliminary findings are being presented at a poster session at the rescheduled annual meeting of the American Association for Cancer Research (AACR) on Sunday, July 13, in Washington, D.C.

"In our study, we found a strong correlation between genetic polymorphisms in two genes and lung cancer risk," said Marjorie Romkes, Ph.D., study co-investigator and associate professor, Center for Clinical Pharmacology, department of medicine and director, General Clinical Research Center Pharmacogenetics Care Laboratory, University of Pittsburgh. "Our findings, while preliminary, suggest that the co-inheritance of mutations in a DNA repair gene called XPD and the cyclin D1 gene may be linked to increased risk of lung cancer in those exposed to tobacco smoke. While we have known that these genes are linked to lung cancer on their own, this is the first time we have observed that they may interact to increase lung cancer risk."

The study compared 173 patients with lung cancer to a control group of 184 healthy individuals and found that mutations in both XPD and cyclin D1 (CCND1) occurred more often in the lung cancer patients. In addition, a strong increase in lung cancer risk was observed among individuals with a smoking history and a combination of mutations in both the XPD and CCND1 genes. Those with a smoking history had an odds ratio of 17.0 compared to non-smokers who had an odds ratio of 6.3.

"These findings are important because they have the potential to help us identify those smokers who have a greater likelihood
'"/>

Contact: Clare Collins or Jocelyn Uhl
412-647-3555
University of Pittsburgh Medical Center
14-Jul-2003


Page: 1 2

Related biology news :

1. Belgian researchers explore revolutionary approach to angiogenesis
2. Tracing genes, biologists show lizard migration is traced to Florida
3. Certain genes boost fish oils protection against breast cancer
4. Fossil genes reveal how life sheds form and function
5. Missing genes may help explain why plague bacteria are so deadly
6. Do genes respond to global warming?
7. Genetic map of important tree genes outlined
8. Mitochondrial genes cause nuclear mischief
9. Identifying tick genes could halt disease, bioterrorism threat
10. A genetic disorder yields insight into genes and cognition
11. Mouse study shows NPAS3 and NPAS1 genes may be linked to psychosis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/10/2020)... ... July 09, 2020 , ... Today CJ BIO announced the first in a ... the “fifth taste” phenomenon that is revolutionizing ingredient mixes, nutritional content and flavor profiles ... on Monday, July 13, 2020 at11:00 AM (CDT) during SHIFT20, the virtual edition of ...
(Date:7/1/2020)... ... July 01, 2020 , ... Cure Glioblastoma, a ... most common and aggressive adult brain cancer—announced today the appointments of its first ... charged with supporting the organization’s initiatives and overall vision. , "Senior Fellows are ...
(Date:6/23/2020)... England (PRWEB) , ... June 23, 2020 , ... ... Africa supporting sustainable healthcare, and Renovagen Ltd, a UK supplier and manufacturer of ... project to support testing operations in the fight against the COVID-19 pandemic in ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... , ... August 11, 2020 ... ... biopharmaceutical cold chain validation engineering firm, is making available for free its ... need to incorporate concurrent transport simulation testing into today’s biologics licensing application ...
(Date:8/3/2020)... ... August 03, 2020 , ... ... announced Jim Corrigan, President and CEO has been named one of the 100 ... of industry sectors, PharmaVoice 100 honorees are selected based on how they have ...
(Date:7/31/2020)... COLLEGE STATION, Texas (PRWEB) , ... July 29, ... ... pre-qualified cleanroom solutions today announced the launch of its new tagline, “BUILDING FOR ... within the biopharmaceutical industry and around the globe, requiring fast track capacity to ...
(Date:7/31/2020)... (PRWEB) , ... July 29, 2020 , ... ... and Catalent, the leading global provider of advanced delivery technologies, development, and manufacturing ... announced that they have entered into a strategic partnership whereby Catalent will provide ...
Breaking Biology Technology:
Cached News: