Type 2 diabetes linked to a family of metabolic genes

BOSTON -- An ambitious and exhaustive genetic study, led by investigators at the Joslin Diabetes Center and the Children's Hospital Boston Informatics Program, has pinpointed a group of genes that are involved in type 2 diabetes and shows that the activity of these genes changes even before overt diabetes develops. The study appears in a July 2003 edition of the Proceedings of the National Academy of Sciences (1).

The investigators at Joslin, led by Dr. Mary-Elizabeth Patti, an endocrinologist and scientist and director of the Genomics Laboratory at Joslin, wanted to identify genes that might be altered in people with diabetes and in those at high risk for the development of diabetes. To do this, they used a microarray a small slide dotted with small pieces of DNA to simultaneously measure the activity of over 7,000 genes in muscle tissue from Mexican-Americans, an ethnic group with a very high risk for diabetes. They compared three groups: subjects with diabetes, healthy subjects without diabetes, and high-risk subjects with "prediabetes" (diabetes in family members).

"Knowing which genes are turned on or off in people before they develop diabetes is a key piece of information needed to solve the puzzle of diabetes, and to identify new ways to treat and prevent this devastating disease," Dr. Patti explains.

Two genes, PCG1-alpha and PCG1-beta, showed reduced activity (also known as expression) not only in the people with diabetes, but also in those with prediabetes. This decreased activity appeared to lead to reduced activity of a larger group of genes involved in the metabolism of fats and carbohydrates. These genes code for proteins in the mitochondria, cell structures that play a critical role in energy metabolism. Reduced activity or expression of these genes may tip the scales to insulin resistance, or an inability of the body's cells to use insulin properly -- the first metabolic defect on the road to type 2 diabetes.


Contact: Rachel Whitehouse
Joslin Diabetes Center

Page: 1 2 3

Related biology news :

1. Joslin Diabetes Center honors brothers living 70-plus years with type 1 diabetes
2. New fruitfly model of diabetes has future implications for pancreatic cell transplantation
3. A probable cause for high blood pressure identified - shows links with diabetes
4. Joslin President awarded medal from international diabetes organization
5. New imaging technology at Joslin shown to detect early signs of type 1 diabetes
6. Protemix corporation announces discovery of way to repair hearts damaged by diabetes
7. Genetic mutation found that is major contributor to type 1 diabetes
8. Joslin researchers identify key molecule in Type 1 diabetes progression
9. Gestational diabetes not found to alter the metabolic processes in obese pregnant women
10. Lab mice rescued from Type 1 diabetes via dendritic cell-assisted therapy
11. Study links diabetes and colorectal cancer

Post Your Comments:

(Date:9/30/2019)... ... September 30, 2019 , ... As human induced pluripotent stem cells (hiPSCs) move ... development and diseases of the human heart, there is an increasing need for stable ... cells to be clearly and easily recorded. A study released today in STEM CELLS ...
(Date:9/25/2019)... , ... September 25, 2019 , ... ... Austin, TX, have placed over 20,000 dental implants for a variety of procedures, ... technical zygomatic and pterygoid dental implants. Dental implants offer patients permanent ...
(Date:9/25/2019)... , ... September 25, 2019 , ... Deep Science ... Cancer Research UK, the world’s largest independent funder of cancer research. , Deep Science ... that takes a systems-level view of the opportunity from the start, both at the ...
Breaking Biology News(10 mins):
(Date:9/24/2019)... Kong (PRWEB) , ... September 24, 2019 , ... Drug ... 2019 by the World Health Organization, with MRSA becoming one of the most serious ... there were 1,218 reported cases of community-associated MRSA (CA-MRSA), or a seven-fold of the ...
(Date:9/24/2019)... ... September 24, 2019 , ... In the past three years, the ... faculty at South Dakota School of Mines & Technology that expands human ... to surfaces to form a slimy and yet strong layer which is commonly known ...
(Date:9/17/2019)... ... September 17, 2019 , ... Geneticure, Inc., a Rochester ... today that the U.S. Patent and Trademark Office (USPTO) and European Patent Office ... class recommendations for hypertension treatment. , The patent applies to Geneticure’s first ...
(Date:9/17/2019)... ... September 16, 2019 , ... MyBioGate ... China Focus @ Biotech Week Boston, a forum organized by MyBioGate, Inc. and ... innovation. , After a careful process of evaluation, twelve companies out of over ...
Breaking Biology Technology:
Cached News: