HOME >> BIOLOGY >> NEWS
Type 2 diabetes linked to a family of metabolic genes

BOSTON -- An ambitious and exhaustive genetic study, led by investigators at the Joslin Diabetes Center and the Children's Hospital Boston Informatics Program, has pinpointed a group of genes that are involved in type 2 diabetes and shows that the activity of these genes changes even before overt diabetes develops. The study appears in a July 2003 edition of the Proceedings of the National Academy of Sciences (1).

The investigators at Joslin, led by Dr. Mary-Elizabeth Patti, an endocrinologist and scientist and director of the Genomics Laboratory at Joslin, wanted to identify genes that might be altered in people with diabetes and in those at high risk for the development of diabetes. To do this, they used a microarray a small slide dotted with small pieces of DNA to simultaneously measure the activity of over 7,000 genes in muscle tissue from Mexican-Americans, an ethnic group with a very high risk for diabetes. They compared three groups: subjects with diabetes, healthy subjects without diabetes, and high-risk subjects with "prediabetes" (diabetes in family members).

"Knowing which genes are turned on or off in people before they develop diabetes is a key piece of information needed to solve the puzzle of diabetes, and to identify new ways to treat and prevent this devastating disease," Dr. Patti explains.

Two genes, PCG1-alpha and PCG1-beta, showed reduced activity (also known as expression) not only in the people with diabetes, but also in those with prediabetes. This decreased activity appeared to lead to reduced activity of a larger group of genes involved in the metabolism of fats and carbohydrates. These genes code for proteins in the mitochondria, cell structures that play a critical role in energy metabolism. Reduced activity or expression of these genes may tip the scales to insulin resistance, or an inability of the body's cells to use insulin properly -- the first metabolic defect on the road to type 2 diabetes.

Th
'"/>

Contact: Rachel Whitehouse
rachel.whitehouse@joslin.harvard.edu
617-732-2415
Joslin Diabetes Center
28-Jul-2003


Page: 1 2 3

Related biology news :

1. Joslin Diabetes Center honors brothers living 70-plus years with type 1 diabetes
2. New fruitfly model of diabetes has future implications for pancreatic cell transplantation
3. A probable cause for high blood pressure identified - shows links with diabetes
4. Joslin President awarded medal from international diabetes organization
5. New imaging technology at Joslin shown to detect early signs of type 1 diabetes
6. Protemix corporation announces discovery of way to repair hearts damaged by diabetes
7. Genetic mutation found that is major contributor to type 1 diabetes
8. Joslin researchers identify key molecule in Type 1 diabetes progression
9. Gestational diabetes not found to alter the metabolic processes in obese pregnant women
10. Lab mice rescued from Type 1 diabetes via dendritic cell-assisted therapy
11. Study links diabetes and colorectal cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2020)... ... August 18, 2020 , ... ... therapy, today announced that the U.S. Food and Drug Administration (FDA) has approved ... asset, SBI-101, for the treatment of severe COVID-19. Approval of this IND allows ...
(Date:8/21/2020)... ... August 19, 2020 , ... ... expo uniting life science, data science, informatics and IT leaders goes VIRTUAL and ... period of uncertainty and change, Bio-IT takes the leadership role of keeping our ...
(Date:8/12/2020)... ... 2020 , ... Both Roche, based in Basel, Switzerland, and ... with Housey Pharma’s HMI subsidiary to gain access to its core-enabling technology for ... Development spending in excess of US $10 billion. , Scientists at Housey Pharma ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... ... August 11, 2020 , ... The FSHD Society announced ... Dystrophy Clinical Trial Research Network (FSHD CTRN), with consideration of follow-on ... consortium of academic research centers in the United States and Europe with expertise ...
(Date:8/3/2020)... ... , ... ERT, the global leader in clinical ... one of the 100 most inspiring individuals in the life-sciences industry by PharmaVoice. ... on how they have inspired their colleagues and affected positive changes in their ...
(Date:7/31/2020)... Mass. (PRWEB) , ... July 29, 2020 , ... ... highly reliable, solid-state radar transmitter systems that can be configured to drive Klystrons, ... single controller that can drive one or two switches in a push-pull configuration; ...
(Date:7/31/2020)... ... , ... The SDX® Respiratory Gating System , trusted ... its 20th anniversary of worldwide use. Introduced in the US over the past ... of Pennsylvania, University of Michigan, University of Maryland, University of California San Francisco—and ...
Breaking Biology Technology:
Cached News: