HOME >> BIOLOGY >> NEWS
U. Iowa muscular dystrophy discovery may lead to new treatment approaches

Expressing high levels of a sugar-adding protein known as LARGE in mice that lack the protein can prevent muscular dystrophy in these animals, according to studies by researchers at the University of Iowa Roy J. and Lucille A. Carver College of Medicine. Furthermore, the research suggests that LARGE protein also can restore normal function to a critical muscle protein that is disrupted by glycosylation (sugar-adding) defects in several different human muscular dystrophies.

The team's findings, which appear June 6 in an advanced online publication of Nature Medicine and online in the journal Cell on June 3, might lead to new treatments for this particular class of muscular dystrophies and other muscle diseases caused by glycosylation defects.

A group of muscular dystrophies, which include Fukuyama Congenital Muscular Dystrophy, Walker-Warburg Syndrome and Muscle-Eye-Brain disease, are caused by mutations in glycosylation enzymes proteins that add sugars to other proteins. In these diseases, defects in the sugar-adding mechanism disrupt the properties of alpha-dystroglycan, a protein critical for normal muscle function.

Previous work by the UI researchers led by Kevin Campbell, Ph.D., the Roy J. Carver Chair of Physiology and Biophysics and interim head of the department, professor of neurology, and a Howard Hughes Medical Institute (HHMI) Investigator, showed that abnormal glycosylation disrupts alpha-dystroglycan's ability to interact with other proteins and leads to muscle degeneration and brain defects in these muscular dystrophies.

LARGE protein is mutated in patients with congenital muscular dystrophy 1D. In the Nature Medicine article, Campbell and his colleagues examined the effect of restoring expression of LARGE in mice that lacked the protein and found that gene transfer of the protein into this animal model of the disease prevented the development of muscular dystrophy.

More surprisingly, the research team also
'"/>

Contact: Jennifer Brown
jennifer-l-brown@uiowa.edu
319-335-9917
University of Iowa
6-Jun-2004


Page: 1 2 3

Related biology news :

1. Newly discovered protein may be key to muscular dystrophy
2. Gene therapy reaches muscles throughout the body and reverses muscular dystrophy in animal model
3. LARGE protein can overcome defects in some types of muscular dystrophy
4. University of Pittsburgh named cooperative research center for muscular dystrophy
5. New prospects for treating muscular dystrophy: Stem cells restore muscle in MD mice
6. Muscle-repair defect underlies two muscular dystrophies
7. UI researchers discover new cause of muscular dystrophies
8. Mighty mice are less susceptible to muscular dystrophy genes effects
9. Gene therapy reverses muscular dystrophy in animal model
10. Scientists discover cause of common muscular dystrophy
11. Scientists identify a new kind of genetic problem in muscular dystrophy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/13/2018)... ... November 13, 2018 , ... ... systems for controlled-environment cultivation applications. VYPR 2 is well suited for sole-source and ... and ornamental growing markets. , “As an all-purpose light which can be ...
(Date:11/13/2018)... , ... November 12, 2018 , ... Board-certified periodontist Dr. ... welcoming individuals with multiple missing teeth in Santa Ana, CA and surrounding areas, who ... day. Using decades of experience, Dr. Kim regularly helps patients get the advantages that ...
(Date:11/9/2018)... Pa. (PRWEB) , ... November 08, 2018 , ... ... with advanced touch screen control. Heating blocks, also known as dry bath incubators ... variety of tubes and containers. , For the new heating blocks, Boekel ...
Breaking Biology News(10 mins):
(Date:11/5/2018)... ... November 05, 2018 , ... ... company backed by Siemens Healthineers and several healthcare VC firms announces at Distributed ... and making a history by purchasing tokens and obtaining its first radiology interpretations, ...
(Date:11/3/2018)... ... November 01, 2018 , ... Come to ... Jean Mulinde, Senior Advisor, Division of Clinical Compliance Evaluation, CDER, FDA will be ... data reliability. , What should clinical research industry stakeholders keep in mind when ...
(Date:10/31/2018)... ... October 30, 2018 , ... Myoscience, Inc. announced today ... Clinic in Memphis, Tennessee. This study enrolled 125 patients and compares the ... managing pain after total knee replacement surgery (TKA). , The Myoscience iovera° system ...
(Date:10/31/2018)... ... October 30, 2018 , ... Today, the National Corn Growers Association (NCGA) announced ... competition is to find new and innovative uses of field corn. NineSigma is serving ... billion bushels of corn and are on pace to produce the second largest crop ...
Breaking Biology Technology:
Cached News: