HOME >> BIOLOGY >> NEWS
U. Iowa muscular dystrophy discovery may lead to new treatment approaches

Expressing high levels of a sugar-adding protein known as LARGE in mice that lack the protein can prevent muscular dystrophy in these animals, according to studies by researchers at the University of Iowa Roy J. and Lucille A. Carver College of Medicine. Furthermore, the research suggests that LARGE protein also can restore normal function to a critical muscle protein that is disrupted by glycosylation (sugar-adding) defects in several different human muscular dystrophies.

The team's findings, which appear June 6 in an advanced online publication of Nature Medicine and online in the journal Cell on June 3, might lead to new treatments for this particular class of muscular dystrophies and other muscle diseases caused by glycosylation defects.

A group of muscular dystrophies, which include Fukuyama Congenital Muscular Dystrophy, Walker-Warburg Syndrome and Muscle-Eye-Brain disease, are caused by mutations in glycosylation enzymes proteins that add sugars to other proteins. In these diseases, defects in the sugar-adding mechanism disrupt the properties of alpha-dystroglycan, a protein critical for normal muscle function.

Previous work by the UI researchers led by Kevin Campbell, Ph.D., the Roy J. Carver Chair of Physiology and Biophysics and interim head of the department, professor of neurology, and a Howard Hughes Medical Institute (HHMI) Investigator, showed that abnormal glycosylation disrupts alpha-dystroglycan's ability to interact with other proteins and leads to muscle degeneration and brain defects in these muscular dystrophies.

LARGE protein is mutated in patients with congenital muscular dystrophy 1D. In the Nature Medicine article, Campbell and his colleagues examined the effect of restoring expression of LARGE in mice that lacked the protein and found that gene transfer of the protein into this animal model of the disease prevented the development of muscular dystrophy.

More surprisingly, the research team also
'"/>

Contact: Jennifer Brown
jennifer-l-brown@uiowa.edu
319-335-9917
University of Iowa
6-Jun-2004


Page: 1 2 3

Related biology news :

1. Newly discovered protein may be key to muscular dystrophy
2. Gene therapy reaches muscles throughout the body and reverses muscular dystrophy in animal model
3. LARGE protein can overcome defects in some types of muscular dystrophy
4. University of Pittsburgh named cooperative research center for muscular dystrophy
5. New prospects for treating muscular dystrophy: Stem cells restore muscle in MD mice
6. Muscle-repair defect underlies two muscular dystrophies
7. UI researchers discover new cause of muscular dystrophies
8. Mighty mice are less susceptible to muscular dystrophy genes effects
9. Gene therapy reverses muscular dystrophy in animal model
10. Scientists discover cause of common muscular dystrophy
11. Scientists identify a new kind of genetic problem in muscular dystrophy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/4/2017)... NEW YORK , April 4, 2017   ... solutions, today announced that the United States Patent and ... The patent broadly covers the linking of an iris ... the same transaction) and represents the company,s 45 th ... our latest patent is very timely given the multi-modal ...
(Date:3/30/2017)... Trends, opportunities and forecast in this market ... (fingerprint, AFIS, iris recognition, facial recognition, hand geometry, vein ... use industry (government and law enforcement, commercial and retail, ... others), and by region ( North America ... Pacific , and the Rest of the World) ...
(Date:3/24/2017)... Controller General of Immigration from Maldives Mr. Mohamed Anwar and ... international IAIR Award for the most innovative high security ePassport and eGates  ... ... Maldives Immigration Controller General, Mr. Mohamed Anwar ... right) have received the IAIR award for the "Most innovative high security ...
Breaking Biology News(10 mins):
(Date:7/17/2017)... ... July 17, 2017 , ... The Academy of Model Aeronautics (AMA) will ... Aviation Day will take place from 9 a.m. to 2 p.m. at the International ... all ages. , Aviation Adventure Day will be packed with entertaining activities for the ...
(Date:7/17/2017)... (PRWEB) , ... July 17, 2017 , ... ... are characterized by a wide range of overlapping clinical features. The advancement of ... in the field of NDD research and testing. , However, designing a ...
(Date:7/17/2017)... ... July 17, 2017 , ... DuPont Pioneer today announced the ... (openinnovation.pioneer.com) dedicated to connecting third-party innovators with DuPont Pioneer scientists is now ... technologies, biologicals and digital solutions. , “DuPont Pioneer is building on its long ...
(Date:7/15/2017)... ... July 15, 2017 , ... Cuvette manufacturer FireflySci ... During this time, the people at FFS have learned that their biggest asset was ... FFS are able to launch new products to meet the changing needs of scientists ...
Breaking Biology Technology:
Cached News: