HOME >> BIOLOGY >> NEWS
U-M scientists find cancer's genetic core: 67 genes universally activated in human cancer

ANN ARBOR, Mich. Of the approximately 35,000 genes in the human genome, scientists at the University of Michigan's Comprehensive Cancer Center have found that activity from just 67 is required to change normal human cells into cancer.

These 67 genes constitute what U-M scientists call cancer's meta-signature a core set of essential genes, which somehow triggers the transformation from normal cells to cells that are neoplastic, or growing abnormally. A list of these genes, and a description of a new database used to identify them, will be published June 7 in the online edition of the Proceedings of the National Academy of Sciences (PNAS).

"We used a statistical analysis method called comparative meta-profiling to examine 40 datasets from other investigators showing specific patterns of genetic activity associated with one of 12 types of cancer," says Daniel Rhodes, the paper's first author and a student in the U-M Medical School's Medical Scientist Training Program and Bioinformatics Graduate Program. "The result was a common transcriptional profile with 67 activated genes present in nearly all cancerous tissue samples in the study, regardless of their tissue of origin."

"This paper is the first to report common patterns of genetic activity across multiple cancer microarray datasets from different investigators," says Arul M. Chinnaiyan, M.D., Ph.D., an associate professor of pathology and urology in the U-M Medical School, who directed the study. "These genes and their associated proteins are the molecular components that make different types of cancer more similar to each other than to normal tissue. Since these genes appear to be involved in so many types of cancer, they are prime targets for new cancer-fighting drugs."

Chinnaiyan, Rhodes and colleagues also identified another 69-gene meta-signature showing a common pattern of genetic activity in aggressive, invasive undifferentiated cancers. The pattern is different from
'"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
7-Jun-2003


Page: 1 2 3 4

Related biology news :

1. DNA lends scientists a hand, revealing new chemical reactions
2. Conference at UH opens doors for new scientists, engineers
3. Wisconsin scientists develop quick botox test
4. UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
5. Alaska scientists find Arctic tundra yields surprising carbon loss
6. UAF scientists discover new marine habitat in Alaska
7. Information system to help scientists analyze mechanisms of social behavior
8. Zoonotic diseases - European scientists unite to fight diseases
9. Israeli scientists reveal the plan of a key cellular machine
10. Study by Israeli scientists provides insight on DNA code
11. Computer scientists at UH developing nurturing computers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/8/2019)... ... January 07, 2019 , ... ... solutions, is proud to welcome Thomas Kennedy as head of sales and business ... for PureWay. , Mr. Kennedy has previously worked for Johnson & Johnson Medical, ...
(Date:1/4/2019)... ... January 02, 2019 , ... Lifecycle Biotechnologies ... the life science tools and service supplier turned 40 in 2018 and for ... catalog features not just part numbers like most catalogs, but rather, insightful information ...
(Date:12/25/2018)... ... 2018 , ... Researchers at the Icahn School of Medicine ... a long-standing computational concept known as “blacklisting,” which is commonly employed as a ... as a filter to single out genetic variations in patient genomes and exomes ...
Breaking Biology News(10 mins):
(Date:1/8/2019)... ... January 08, 2019 , ... The American Society of ... were named by a selection committee made up of industry leaders identified by the ... Development grants are mentored awards created to support ASGCT members designing transformative pilot studies ...
(Date:1/4/2019)... (PRWEB) , ... January 01, 2019 , ... ... first Microbiome Conference at the World Economic Forum Annual Meeting January 22-25, 2019 ... conference is invitation-only. , The World Economic Forum Annual Meeting brings together leaders ...
(Date:12/20/2018)... ... ... New Year’s brings reflection and desire to improve for individuals and businesses ... on the horizon, Jim Kasic, president and CEO of Boulder iQ, suggests five resolutions ... Regulation (MDR), digital health, and big data are just a few of the challenges ...
(Date:12/18/2018)... ... December 17, 2018 , ... ABCT , ... biosciences ventures invited to participate in the annual program. Twelve ventures will participate ... and a professional network. All startups receive an entrepreneur coach, access to active ...
Breaking Biology Technology:
Cached News: