HOME >> BIOLOGY >> NEWS
U-M scientists use 21st-century technology to probe secrets of M. tuberculosis

NEW ORLEANS University of Michigan microbiologists have created a virtual model of the human immune system that runs "in silico" to study what happens inside the lungs after people inhale Mycobacterium tuberculosis, the bacterium that causes TB.

The computer model is helping scientists learn more about this ancient pathogen, and why some people are able to fight off the infection, while others get sick. U-M scientists believe the answer could be hidden inside structures called granulomas, which immune cells build to surround and contain invading M. tuberculosis bacteria.

"Granulomas are the hallmark of tuberculosis," says Denise Kirschner Ph.D., an associate professor of microbiology and immunology in the U-M Medical School. "It's the immune system's fail-safe response to infection. If the immune system can't clear the pathogen, it gets out the masonry and walls it off."

Kirschner presented research results and an analysis of time-lapse computer animations showing granuloma formation at a May 26 seminar during the American Society for Microbiology's annual meeting held here this week.

"M. tuberculosis has been living with people for at least 4,000 years," says Kirschner. "Because the bug has had all those years to get to know us so well, it has evolved several effective ways to circumvent the immune system's ability to detect and kill invading pathogens. Scientific knowledge of how the immune system interacts with M. tuberculosis is slowly improving, but we are far from prevention or an effective vaccine. It's important to understand TB, because the disease is a serious and growing public health problem."

According to Kirschner, approximately 2 billion people worldwide are infected with M. tuberculosis, and the disease kills about 3 million people every year. In the early stages of infection, tuberculosis can be treated with powerful antibiotics, but there is no cure. And multi-drug-resistant strains, which are essentially
'"/>

Contact: Sally Pobojewski
pobo@umich.edu
734-615-6912
University of Michigan Health System
26-May-2004


Page: 1 2 3

Related biology news :

1. DNA lends scientists a hand, revealing new chemical reactions
2. Conference at UH opens doors for new scientists, engineers
3. Wisconsin scientists develop quick botox test
4. UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
5. Alaska scientists find Arctic tundra yields surprising carbon loss
6. UAF scientists discover new marine habitat in Alaska
7. Information system to help scientists analyze mechanisms of social behavior
8. Zoonotic diseases - European scientists unite to fight diseases
9. Israeli scientists reveal the plan of a key cellular machine
10. Study by Israeli scientists provides insight on DNA code
11. Computer scientists at UH developing nurturing computers

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: scientists use century technology probe secrets tuberculosis

(Date:4/8/2015)... 2015  Infinisource, a leading provider of SaaS-based Human ... a leading supplier of biometric identification and security ... most advanced biometrically-enabled time clock, the companies announced ... is setting a bold, new standard for the ... small and mid-size employer. When connected to the ...
(Date:4/2/2015)... Fingerprint Cards (FPC) has received ... the distributor World Peace Industrial Group (WPI), part of ... the major part of the shipments will take place ... smartphone manufacturers in China . The ... communicated revenue guidance of + 1 000 MSEK for 2015.  ...
(Date:3/30/2015)... and Markets ( http://www.researchandmarkets.com/research/lc9bnl/global_gesture ) has announced ... in Automotive Sector 2014-2018" report to their offering. ... market in Automotive Sector to grow at a CAGR ... recognition is the ability of a device to identify ... recognition technology can be 2D-based or 3D-based. It uses ...
Breaking Biology News(10 mins):iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2
(Date:4/24/2015)... Seoul Semiconductor announced the expansion of its ... lighting market. In recent months, there have ... emerging markets such as Russia, South America, and ... such as streetlight and area lighting, tunnel lighting, ... in 2005 the Acrich technology from Seoul Semiconductor ...
(Date:4/23/2015)... Athena San Diego, an organization that accelerates ... San Diego’s technology and life science sectors, will announce ... their Gala on April 30, 2015 from 5-9pm at ... http://athenasd.org/events/ , The Pinnacle Awards recognize individuals and ... of fostering networking, risk taking and diversity of thought, ...
(Date:4/23/2015)... , April 23, 2015 /CNW/ - A new ... packaging award from North America,s ... Competitor Comparison won Silver in the "Sustainability, service" ... The Brandcheck "Competitor Comparison" is a service ... North American and Global peers. This benchmarking process ...
(Date:4/23/2015)... Six startups from Russia traveled to ... part of the U.S.-Russia Innovation Corridor (USRIC) program. ... startups to participate in the program since the ... University of Maryland (UMD) signed a Memorandum of ... in the biomedical industry in 2013. , Supported ...
Breaking Biology Technology:Acrich Technology from Seoul Semiconductor Adopted in Installations Worldwide 2Athena Pinnacle Awards to Honor Executives, Corporations and Educators Working to Promote Women Leaders 2U.S.-Russian Innovation Corridor Program Connects Visiting Russian Startups to U.S. Experts 2U.S.-Russian Innovation Corridor Program Connects Visiting Russian Startups to U.S. Experts 3U.S.-Russian Innovation Corridor Program Connects Visiting Russian Startups to U.S. Experts 4
Cached News: