U of Minnesota researchers identify gene for myotonic muscular dystrophy Type 2

Findings demonstrate that RNA can cause genetic diseases

MINNEAPOLIS / ST. PAUL (August 1, 2001) University of Minnesota researchers have pinpointed the gene on chromosome 3 that causes myotonic dystrophy Type 2 (DM2). The findings will be reported in the August 3 issue of Science.

Myotonic dystrophy (DM), the most common form of muscular dystrophy in adults, affects the eyes, heart, hormonal systems and blood, in addition to causing muscular dystrophy and involuntary muscle stiffness (myotonia). Although the genetic change underlying one form of myotonic dystrophy (DM1) was found on chromosome 19 in 1992, scientists have disagreed about how it causes disease. Dr. Laura Ranum, an associate professor in the department of genetics, cell biology and development and the Institute of Human Genetics, and Dr. John W. Day, an associate professor in the department of neurology and the Institute of Human Genetics, have characterized the second form of myotonic dystrophy (DM2) in an effort to clarify the cause of this complex disease. They located the genetic cause of DM2 on chromosome 3 in 1998 (Nature Genetics 19:196), and have collaborated with investigators in Germany and Texas to find the underlying genetic mutation. The new report describes the mutation they found, which indicates that abnormal RNA causes both DM1 and DM2.

"RNA is the messenger molecule that translates the DNA code into proteins," said Ranum. "In the past the focus has been on protein abnormalities as the cause of genetic disorders, and researchers thought that RNA had little or no direct role in causing disease. Our findings indicate that additional research is needed to examine the role of RNA in human disease."

The findings reported in Science indicate that DM2 is caused by an expansion located in intron 1 of the zinc finger protein 9 (ZNF9) gene.

"These results enable us to focus our research and to work towards eliminating this disease for

Contact: Sarah Youngerman
University of Minnesota

Page: 1 2

Related biology news :

1. University of Minnesota professors to speak at symposium on international trade
2. U of Minnesota receives NSF grant to sequence bacterial genome
3. University of Minnesota receives NSF grant to sequence legume genome
4. U of Minnesota leads effort to break impasse over GMO safety
5. U of Minnesota study: Adult bone marrow stem cells can become liver cells
6. NSF awards two plant genome grants to University of Minnesota
7. Impact of genetically engineered fish subject of U of Minnesota study
8. Minnesota researcher receives award for improving food service worker safety
9. Could Minnesota forestry save the Siberian tiger?
10. Belgian researchers explore revolutionary approach to angiogenesis
11. Award winning researchers reveal potential new role for Glivec

Post Your Comments:

(Date:6/28/2020)... ... June 25, 2020 , ... In an upcoming episode scheduled for ... Point of Care Testing solutions (POCT). Check local listings for more info. , Today, ... offices and are shipped to labs throughout the country. Results are then available several ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... gene-to-protein and monoclonal antibody development services, today announced that the company has ... services to the pharmaceutical, diagnostics, and research industries. The decision to pursue ...
(Date:6/23/2020)... TORONTO (PRWEB) , ... June 22, 2020 , ... The ... time. Typically, ligand binding assays (LBA) have dominated this area. However, the use of ... several years. , This now necessitates the question “How do you choose which approach ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... , ... July 29, 2020 , ... ... of the top radiation centers in 16 countries, has reached its 20th anniversary ... is now in routine use at top universities including University of Pennsylvania, University ...
(Date:7/18/2020)... ... July 16, 2020 , ... “We are thrilled to deliver this new ... only technology of its kind on the market and we were pleased that the ... capacity of traditional cultured ingredients, creating a natural way to extend the shelf life ...
(Date:7/10/2020)... ... July 09, 2020 , ... ... Institute of Technology (MIT) has expanded the company’s exclusive license to include ... into the point-of-care diagnostic market, focusing initially on the SARS-CoV-2 biosensor. ...
(Date:7/7/2020)... (PRWEB) , ... July 06, 2020 , ... ... Practices Awards. Entries from Roche, Eli Lilly, Bristol-Myers Squibb, the University of Chicago, ... 2003, Bio-IT World has hosted an elite awards program, highlighting outstanding examples of ...
Breaking Biology Technology:
Cached News: