HOME >> BIOLOGY >> NEWS
UB Researcher Developing Method That Employs "Evolution" To Identify New Drug Leads

atorial chemistry," he said.

The new method synthesizes many different compounds at once in complex mixtures. Then, because of the presence of a molecular target, its components naturally will evolve into the best candidate molecules.

"This method employs basic principles of Darwinian evolution," said Eliseev. "It's survival of the fittest. Our method increases the amount of the desirable compounds and decreases the amount of the undesirable ones."

Unlike other combinatorial methods, the UB method works by using molecular recognition -- the ability of molecules to bind to a target -- to simultaneously form and screen mixtures of many chemicals for the best ones.

During a stage the scientists call equilibration, or variation, the components of these mixtures are manipulated by the presence of the molecular target to "evolve" higher fractions of the best compounds.

"Our mixture circulates through two chromatographic columns," explained Eliseev. "In one of them, which we call the selection chamber, the effective components bind to the immobilized target compound. In the other one, the remaining mixture is brought to an equilibrium, where the mixture regenerates the fraction of the effective binders it just lost."

In the same way that natural evolution plays out over the course of many generations, chemical evolution occurs over the course of many repeated cycles during which the chemical library continually reforms itself, evolving a much larger subset of effective components.

These components then are isolated from the mixture and analyzed to identify potential drug leads.

The method has been proven in a model system.

The UB scientists are using it to develop drug candidates against the enzyme pepsin, which is found in the stomach and involved in the formation of ulcers.


'"/>

Contact: Ellen Goldbaum
goldbaum@newsb.buffalo.edu
716-645-2626
University at Buffalo
22-May-1998


Page: 1 2

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/22/2016)... June 22, 2016   Acuant , ... verification solutions, has partnered with RightCrowd ® ... for Visitor Management, Self-Service Kiosks and Continuous ... that add functional enhancements to existing physical ... and venues with an automated ID verification ...
(Date:6/16/2016)... June 16, 2016 The ... expected to reach USD 1.83 billion by 2024, ... Research, Inc. Technological proliferation and increasing demand in ... expected to drive the market growth. ... The development of advanced multimodal techniques for ...
(Date:6/7/2016)... -- Syngrafii Inc. and San Antonio Credit Union (SACU) ... Syngrafii,s patented LongPen™ eSignature "Wet" solution into SACU,s ... in greater convenience for SACU members and operational ... document workflow and compliance requirements. Logo ... Highlights: ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... 27, 2016  Liquid Biotech USA ... of a Sponsored Research Agreement with The University ... (CTCs) from cancer patients.  The funding will be ... correlate with clinical outcomes in cancer patients undergoing ... then be employed to support the design of ...
(Date:6/24/2016)... SAN DIEGO , June 24, 2016 /PRNewswire/ ... that more sensitively detects cancers susceptible to PARP ... individual circulating tumor cells (CTCs). The new test ... of HRD-targeted therapeutics in multiple cancer types. ... therapies targeting DNA damage response pathways, including PARP, ...
(Date:6/23/2016)... Seattle, WA (PRWEB) , ... June 23, 2016 ... ... technology, announces the release of its second eBook, “Clinical Trials Patient Recruitment and ... patient recruitment and retention in this eBook by providing practical tips, tools, and ...
(Date:6/23/2016)... TORONTO , June 23, 2016 /PRNewswire/ - ... Ontario biotechnology company, Propellon ... the development and commercialization of a portfolio of ... cancers. Epigenetic targets such as WDR5 represent an ... contribute significantly in precision medicine for cancer patients. ...
Breaking Biology Technology:
Cached News: