HOME >> BIOLOGY >> NEWS
UB Researcher Developing Method That Employs "Evolution" To Identify New Drug Leads

atorial chemistry," he said.

The new method synthesizes many different compounds at once in complex mixtures. Then, because of the presence of a molecular target, its components naturally will evolve into the best candidate molecules.

"This method employs basic principles of Darwinian evolution," said Eliseev. "It's survival of the fittest. Our method increases the amount of the desirable compounds and decreases the amount of the undesirable ones."

Unlike other combinatorial methods, the UB method works by using molecular recognition -- the ability of molecules to bind to a target -- to simultaneously form and screen mixtures of many chemicals for the best ones.

During a stage the scientists call equilibration, or variation, the components of these mixtures are manipulated by the presence of the molecular target to "evolve" higher fractions of the best compounds.

"Our mixture circulates through two chromatographic columns," explained Eliseev. "In one of them, which we call the selection chamber, the effective components bind to the immobilized target compound. In the other one, the remaining mixture is brought to an equilibrium, where the mixture regenerates the fraction of the effective binders it just lost."

In the same way that natural evolution plays out over the course of many generations, chemical evolution occurs over the course of many repeated cycles during which the chemical library continually reforms itself, evolving a much larger subset of effective components.

These components then are isolated from the mixture and analyzed to identify potential drug leads.

The method has been proven in a model system.

The UB scientists are using it to develop drug candidates against the enzyme pepsin, which is found in the stomach and involved in the formation of ulcers.


'"/>

Contact: Ellen Goldbaum
goldbaum@newsb.buffalo.edu
716-645-2626
University at Buffalo
22-May-1998


Page: 1 2

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
(Date:4/18/2014)... Asteroid and comet impacts can cause widespread ecological ... even global scales. But new research from Brown University ... ancient life at the time of an impact. , ... has found fragments of leaves and preserved organic compounds ... in Argentina. The material could provide a snapshot of ...
(Date:4/17/2014)... A drug under clinical trials to treat tuberculosis ... drugs that act against various bacteria, fungal infections and ... University of Illinois chemists and collaborators. , Led by ... determined the different ways the drug SQ109 attacks the ... target other pathogens from yeast to malaria and ...
(Date:4/17/2014)... of stem cell therapies to cure a variety of ... populations based on cell surface markers. Researchers from the ... is highly expressed in a type of stem cells ... in an article in BioResearch Open Access , ... The article is available free on the ...
Breaking Biology News(10 mins):Impact glass stores biodata for millions of years 2Impact glass stores biodata for millions of years 3Multitarget TB drug could treat other diseases, evade resistance 2
(Date:1/14/2014)... (PRWEB) January 14, 2014 Carahsoft and ... Thursday, January 23, 2014 at 2pm EST (11am PST), ... The topic focuses on how technology can turn raw, ... decisions for government agencies. The online webinar will last ...
(Date:1/14/2014)... 14, 2014 EquitiesIQ, a leading informational ... ALQA). Alliqua is an emerging biomedical company acquiring, developing, ... care market. , Free report download: http://equitiesiq.com/reports/alliqua/ ... seasoned management team and Board, which launched the company’s ...
(Date:1/14/2014)... 14, 2014 In recent years, growing ... methods in product development and promotion has led to ... mistrust, fueled by concerns about the insidious impact of ... of spectacular fines to the world’s biggest pharmas for ...
(Date:1/14/2014)... Bellingham, Washington, USA, and Cardiff, UK (PRWEB) January 13, ... and photonics technology development leader with more than 20 ... international society for optics and photonics . Hainsey will ... “We are delighted to have Dr. Hainsey join SPIE ...
Breaking Biology Technology:Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2
Cached News: