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UB biophysicists discover high-speed motility in cells in response to voltage changes

BUFFALO, N.Y. -- University at Buffalo biophysicists studying the motility of cells have shown that simple cells react in less than a millisecond to changes in membrane voltage, a property scientists have thought was confined to highly specialized cells such as the cochlear outer hair cells responsible for hearing.

In addition to providing new, basic information on how cells function, the finding calls into question the accepted purpose of the so-called "motor protein" prestin, which was thought to be essential for outer-hair-cell motility in the cochlea.

"We have found that cells 'wiggle' at high speed when voltage changes," said Frederick Sachs, Ph.D., UB professor of physiology and biophysics and the study's senior author. "They don't need any special proteins or lipids" to accomplish the movement.

Sachs is director of UB's Center for Single Molecule Biophysics and an authority on cell mechanics. The study appears in the Sept. 27 issue of the journal Nature.

Sachs and colleagues achieved their findings using instruments that can detect movements smaller than the diameter of a hydrogen atom. The measurement technique involves an atomic force microscope that uses a laser to measure the position of a pointed silicon probe, much as a phonograph needle tracks the grooves in a record. These experiments also allowed the researchers, for the first time, to compute the charge that is bound to the inner surface of a cell membrane.

The discovery of this basic property of cells, irrespective of their sophistication, came somewhat serendipitously. Sachs and colleagues had been trying to measure the motion of single ion channels, membrane proteins that function as biological transistors and control cells' voltage. Surprisingly, they found that the membrane itself moved with voltage. Even more surprising, they found that by diluting the concentration of ions in the solution bathing cells, they could reverse the direction of movement.

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Contact: Lois Baker
ljbaker@buffalo.edu
716-645-5000 x1417
University at Buffalo
27-Sep-2001


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