HOME >> BIOLOGY >> NEWS
UB biophysicists discover high-speed motility in cells in response to voltage changes

BUFFALO, N.Y. -- University at Buffalo biophysicists studying the motility of cells have shown that simple cells react in less than a millisecond to changes in membrane voltage, a property scientists have thought was confined to highly specialized cells such as the cochlear outer hair cells responsible for hearing.

In addition to providing new, basic information on how cells function, the finding calls into question the accepted purpose of the so-called "motor protein" prestin, which was thought to be essential for outer-hair-cell motility in the cochlea.

"We have found that cells 'wiggle' at high speed when voltage changes," said Frederick Sachs, Ph.D., UB professor of physiology and biophysics and the study's senior author. "They don't need any special proteins or lipids" to accomplish the movement.

Sachs is director of UB's Center for Single Molecule Biophysics and an authority on cell mechanics. The study appears in the Sept. 27 issue of the journal Nature.

Sachs and colleagues achieved their findings using instruments that can detect movements smaller than the diameter of a hydrogen atom. The measurement technique involves an atomic force microscope that uses a laser to measure the position of a pointed silicon probe, much as a phonograph needle tracks the grooves in a record. These experiments also allowed the researchers, for the first time, to compute the charge that is bound to the inner surface of a cell membrane.

The discovery of this basic property of cells, irrespective of their sophistication, came somewhat serendipitously. Sachs and colleagues had been trying to measure the motion of single ion channels, membrane proteins that function as biological transistors and control cells' voltage. Surprisingly, they found that the membrane itself moved with voltage. Even more surprising, they found that by diluting the concentration of ions in the solution bathing cells, they could reverse the direction of movement.

"Whe
'"/>

Contact: Lois Baker
ljbaker@buffalo.edu
716-645-5000 x1417
University at Buffalo
27-Sep-2001


Page: 1 2

Related biology news :

1. New hydrothermal vents discovered as South Pacific Odyssey research begins
2. Scientists discover potential new way to control drug-resistant bacteria
3. UAF scientists discover new marine habitat in Alaska
4. Researchers develop fast track way to discover how cells are regulated
5. Researchers discover why mutant gene causes colon cancer
6. A new protein is discovered to play a key role in cancer progression
7. Veterinarians discover first known case of canine distemper in a wild tiger
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Protemix corporation announces discovery of way to repair hearts damaged by diabetes
10. Chemical engineers discover filtration system to help biotech industry
11. Newly discovered protein may be key to muscular dystrophy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/13/2020)... ... 2020 , ... Cryo-Cell International’s announcement is concurrent with the ... Hal Boxmeyer and colleagues, which determined sample viability of 23.5 years and suggested ... Cryo-Cell International marks the first family cord blood bank to release results concerning ...
(Date:3/13/2020)... ... March 13, 2020 , ... Acumed LLC today ... the exclusive distributor of the Louisville-based company’s orthobiologics portfolio. Under the terms of ... distribute Vivorte’s calcium phosphate-based bone allograft (Trabexus) and calcium phosphate-based biocement (Fortera). Vivorte ...
(Date:3/11/2020)... ... March 11, 2020 , ... ... sensing, today announced smart human body temperature infrared touch-free monitoring product family, a ... meter WxS x800-IRTM, supporting flexible wireless uplink for cloud connectivity such as NB-IoT, ...
Breaking Biology News(10 mins):
(Date:3/10/2020)... (PRWEB) , ... March 10, 2020 , ... Ortho Clinical ... through innovative laboratory solutions, announced its ORTHOTM Sera, ID-MTS, a suite of extended antigen ... transfusion, is cleared to run on ORTHO VISION® and ORTHO VISION® Max in the ...
(Date:3/4/2020)... ... ... This month, Cognosante will make its annual appearance at the HIMSS Global Health ... offerings that align with the HIMSS annual theme, “Be the Change.” , Cognosante’s ... From Interoperability and HIE to Cloud Computing and ...
(Date:2/28/2020)... ... February 26, 2020 , ... Designed primarily ... camera with a dedicated controller, thus simplifying setup, streamlining integration, and optimizing workflow. ... the first of Fastec Imaging’s new HS Series cameras to be released. The ...
(Date:2/21/2020)... ... 20, 2020 , ... The dietary supplement industry now has ... listed on an ingredient panel is actually in their product. As a ... adoption of CertainT, which is designed to protect the intellectual property (IP) of ...
Breaking Biology Technology:
Cached News: