UB scientists find breast-cancer risk may be influenced by gene that regulates serum triglycerides

ATHENS, GREECE -- University at Buffalo researchers have shown for the first time that a variant of the apolipoprotein E (apoE) gene, known as apoE 4, may increase the risk of breast cancer by inhibiting the elimination of serum triglycerides from the bloodstream.

While women with the highest triglyceride levels had a slight increase in risk of breast cancer, those with the highest levels, plus the apoE 4 genotype, had a four-fold increase in risk.

"We think that apoE 4 keeps serum triglyceride levels elevated by reducing their clearance," said Kirsten Moysich, Ph.D., a molecular epidemiologist at UB and Roswell Park Cancer Institute, who is working with colleagues from the UB Department of Social and Preventive Medicine. "Triglycerides themselves appear to be a risk factor for breast cancer by reducing sex-hormone-binding globulin levels, which may lead to higher endogenous estrogen levels. This genotype seems to keep levels of triglycerides constantly high."

Moysich presented her findings here today (Sept. 6) at the annual meeting of the International Society for Environmental Epidemiology. The study also has been accepted for publication.

The apoE gene in its three variations -- e2, e3 and e4 -- is involved in lipid metabolism. The e4 variant has been associated with elevated levels of cholesterol and triglycerides, and with an increased risk of coronary disease and Alzheimer's disease, Moysich said.

To determine if apoE 4 also influences the association between serum triglycerides and breast cancer, Moysich and colleagues analyzed blood samples from 256 women with primary breast cancer and 325 controls for triglyceride levels and apoE genotype. Twenty-four percent of the women in the study were found to have the apoE 4 gene.

The results showed no relationship between increased breast-cancer risk and apoE genotype when comparing only genotypes. Women with the highest levels of tr

Contact: Lois Baker
University at Buffalo

Page: 1 2

Related biology news :

1. DNA lends scientists a hand, revealing new chemical reactions
2. Conference at UH opens doors for new scientists, engineers
3. Wisconsin scientists develop quick botox test
4. UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
5. Alaska scientists find Arctic tundra yields surprising carbon loss
6. UAF scientists discover new marine habitat in Alaska
7. Information system to help scientists analyze mechanisms of social behavior
8. Zoonotic diseases - European scientists unite to fight diseases
9. Israeli scientists reveal the plan of a key cellular machine
10. Study by Israeli scientists provides insight on DNA code
11. Computer scientists at UH developing nurturing computers

Post Your Comments:

(Date:8/21/2020)... ... August 19, 2020 , ... The 19th Annual Bio-IT ... data science, informatics and IT leaders goes VIRTUAL and announces its updated event ... change, Bio-IT takes the leadership role of keeping our life science community connected ...
(Date:8/12/2020)... ... August 11, 2020 , ... ... in Princeton, NJ, have entered into license agreements with Housey Pharma’s HMI subsidiary ... Both Roche and J&J have annual Research and Development spending in excess of ...
(Date:8/7/2020)... , ... August 06, 2020 , ... ... industry, is pleased to announce that Eric Chen and Jessica Wong have joined ... Product Management & Strategy, respectively. , Eric Chen heads development efforts for Alucio’s ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... ... August 12, 2020 , ... Inc. magazine ... global leader in FDA compliance consulting has been named on its annual Inc. ... list represents a unique look at the most successful companies within the American ...
(Date:7/31/2020)... COLLEGE STATION, Texas (PRWEB) , ... July 29, ... ... pre-qualified cleanroom solutions today announced the launch of its new tagline, “BUILDING FOR ... within the biopharmaceutical industry and around the globe, requiring fast track capacity to ...
(Date:7/31/2020)... MIAMI (PRWEB) , ... July 29, 2020 , ... ... nearly 200 of the top radiation centers in 16 countries, has reached its ... years, SDX® is now in routine use at top universities including University of ...
(Date:7/18/2020)... ... July 16, 2020 , ... Medial ... early detection and prevention of high-burden diseases, and Centric Consulting, a business and ... organizations to utilize existing data in order to identify and prioritize patients for ...
Breaking Biology Technology:
Cached News: