HOME >> BIOLOGY >> NEWS
UC Berkeley biologist disputes current dogma that genetic mutation is the cause of cancer

Berkeley -- A University of California, Berkeley, scientist is challenging one of the central tenets of cancer research, that cancer results from a chance series of genetic mutations that drive a cell into wild, uncontrolled growth.

Molecular biologist Peter Duesberg, better known for his claim that the human immunodeficiency virus is not the cause of AIDS, contends that mutation is not the cause of cancer. Rather, he says, cancer results from disruption of the normal number of chromosomes in a cell, primarily duplication of one or more chromosomes.

Called aneuploidy, this type of chromosomal abnormality is found in nearly every solid cancer studied to date, but has always been considered a side effect of cancer, not the cause itself.

In a peer-reviewed article in the March 28 issue of the journal Proceedings of the National Academy of Sciences, Duesberg and his colleagues at UC Berkeley argue instead that aneuploidy is the primary cause of cancer and explains many aspects of cancer that the genetic mutation theory cannot.

For some 25 years, Duesberg has pointed out problems with the genetic mutation theory of cancer. Now that the theory has become almost dogma, he is ratcheting up his criticism and receiving support from numerous other scientists

"Peter won't let the field stand still, which is extremely important," said Avery A. Sandberg, chief editor of the journal Cancer Genetics and Cytogenetics. "Once scientists think of one theory as being the de facto theory, we're in great trouble."

If Duesberg is right, it would overthrow a theory that has dominated thinking for the past 15 years, guiding research and dictating how doctors detect and prevent cancer. One field that would feel the impact is cancer screening.

"Rather than looking for mutations in biopsied cells, we should look for aneuploidy as a sign of early cancer," said Duesberg, a professor of molecular and cell biology.

A group of physicians at UC San Francisco is now
'"/>

Contact: Robert Sanders
rls@pa.urel.berkeley.edu
510-643-6998
University of California - Berkeley
4-Apr-2000


Page: 1 2 3 4 5

Related biology news :

1. Landmark gene agreement announced by Samoan government and UC Berkeley for anti-AIDS drug Prostratin
2. Landmark agreement between Samoa and UC Berkeley could help search for AIDS cure
3. Berkeley Lab soil scientist Margaret Torn receives Presidential Early Career Award
4. MSU group reviews Berkeley venture into brave new science funding world
5. UC Berkeley museum biologists to repeat 85-year-old Yosemite National Park wildlife survey
6. Berkeley scientists create first 3-D map of protein universe
7. UC Berkeley scientists detail neural circuit that lets eye detect directional motion
8. UC Berkeley, Joint Genome Institute target chloroplasts for clues to green plant evolution
9. Your brain is teaching your nose new tricks, say UC Berkeley researchers
10. UC Berkeley researchers are developing a microsized microscope that can peek inside living cells
11. Dietary supplements make old rats youthful, may help rejuvenate aging humans, according to UC Berkeley study

Post Your Comments:
(Date:10/18/2014)... for evaluation of suspected genetic conditions, whole-exome sequencing ... including detection of a number of rare genetic ... to a study appearing in JAMA . ... the American Society of Human Genetics annual meeting. ... regions of thousands of genes simultaneously using next-generation ...
(Date:10/17/2014)... Researchers from the University of Copenhagen have shown for ... the lungs of Cystic fibrosis patients, giving them the ... growth in chronic infections. , The study also discovered ... fibrosis (CF) patients was halted or slowed down by ... consumed all the oxygen and helped "suffocate" the bacteria, ...
(Date:10/16/2014)... a new synthesis of recent research findings to inform ... the two states. , The Ecology and Management ... A Synthesis of the Relevant Biophysical Science and Implications ... by the U.S. Forest Service,s Pacific Northwest Research Station, ... for a synthesis of the large body of scientific ...
Breaking Biology News(10 mins):Whole-exome sequencing shows potential as diagnostic tool 2Scientists opens black box on bacterial growth in cystic fibrosis lung infection 2New report synthesizes best available science on management of moist mixed-conifer forests 2
(Date:10/20/2014)... 2014 Convey Computer , the ... from Iowa State University won first place in the ... Convey HC-2ex, the team’s solution achieved the highest overall ... the second place finisher. , Experts from all segments ... month long challenge, using a variety of design tools, ...
(Date:10/20/2014)...  GenVec, Inc. (NASDAQ: GNVC ) today announced ... its board of directors effective on October 24, 2014.   Dr. ... as its chairman from June 2006 to November 2013.  During ... Governance and Audit Committees of the board.  ... dedicated service to GenVec, and its stockholders," said Wayne ...
(Date:10/20/2014)... OR (PRWEB) October 20, 2014 Local ... participate in an investigational study of donor stem cells ... in stem cell therapy and has performed clinical stem ... this study is to determine if a single injection ... affected joints can help reduce pain and inflammation in ...
(Date:10/19/2014)... 19, 2014 The Asia-Pacific Bromine ... in Asia-Pacific with analysis and forecast of revenue. ... Pacific Bromine Market report, to get an idea ... a glimpse of the segmentation in the Asia-Pacific ... and figures. , http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html , ...
Breaking Biology Technology:Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 3Zola P. Horovitz To Retire From GenVec Board 2Cascade Veterinary Referral Center Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3
Cached News: