HOME >> BIOLOGY >> NEWS
UC San Francisco patents method for delivering normal genes in a pill

The first patent for a method of delivering normal genes in a pill to induce the production of insulin in people with diabetes was issued May 1 to the University of California, San Francisco by the United States Patent and Trademark Office.

Sometimes referred to as a "gene pill," the oral delivery of normal genes has been a long-sought and elusive technique. Now, UCSF researchers have successfully demonstrated that raw DNA taken orally can find its way inside cells lining the intestinal tract and prompt those cells to express a protein, such as insulin, even though they are not specialized for that purpose.

"Considerable work still needs to be done before there is an actual gene pill for insulin production, but the patent demonstrates the validity of the concept and promises to spur development of oral delivery of genes to treat a vast number of illnesses," said Stephen S. Rothman, PhD, professor of physiology in the UCSF Schools of Medicine and Dentistry.

The technique holds the potential for providing patients with more than 50 proteins normally secreted by the body into blood and which patients now receive by injection into muscles - including insulin, growth hormones, blood factors for treating hemophilia, and erythropoietin for treating anemia. Rothman expressed confidence that future patent awards to UCSF would cover development of the method for many illnesses.

Genteric, a biotechnology company in Alameda, Calif. has an exclusive, worldwide license agreement with the University to use the method for drug development. The inventors of the technique - Rothman; Michael S. German, MD, associate professor of medicine in the UCSF Hormone Research Institute; and Ira Goldfine, MD, UCSF professor of medicine - along with Michael H. Nantz, PhD, professor of chemistry at UC Davis, are the founders of Genteric.

The research team began studying the technique at UCSF five years ago with funding from the UCSF Foundation and
'"/>

Contact: Bill Gordon
bgordon@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
2-May-2001


Page: 1 2 3

Related biology news :

1. VIB presents its annual results at BIO2004 in San Francisco
2. Invasive cordgrass in San Francisco Bay
3. Life in ice scientist hopes for power in San Francisco
4. Taking the show on the road - Leading researchers to conduct hands-on science symposium for 500 San Francisco area high school students
5. Massive new research effort will map inner workings of cells - San Francisco VA Medical Center chosen to host core laboratory
6. A more accurate measure of exercise ability in older people reported by San Francisco VA Medical Center researchers
7. Futurist research highlights chemists national meeting March 26-30 in San Francisco
8. NASA Exhibit In San Francisco To Show How Space Research Improves Health Care On Earth
9. University Of California-San Francisco Researchers Report Test That Detects Prion Diseases, Illuminates Novel Findings About Infectious Prions
10. University Of California-San Francisco (UCSF) Translational Symposium, September 10, To Focus On HIV Breakthrough And Immune Function
11. HIV Patients Often Experience Viral "Breakthrough," But May Still Remain Healthy, San Francisco Study Finds

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/25/2019)... ... 2019 , ... uBiome, the leader in microbial genomics, announces ... Jackson Laboratory (JAX), to its Scientific Advisory Board. Joining the board of leading ... expertise in skin microbial interactions and probiotic treatments for skin and infectious diseases. ...
(Date:1/24/2019)... (PRWEB) , ... January 23, 2019 , ... ... that it has received a Notice of Allowance from the United States Patent ... filed by its affiliate company, DNA Medicine Institute (DMI). This application covers the ...
(Date:1/20/2019)... ... 2019 , ... uBiome, the leader in microbial genomics, has ... intelligence (AI) and a data-centric approach to decentralize medicine using blockchain to better ... will Crohn’s or other chronic medical conditions join a relevant study through the ...
Breaking Biology News(10 mins):
(Date:2/2/2019)... ... , ... Stay on top of current hot topics through free webinars presented ... webinars is free, so be sure to register today to save your place! Participate ... check out our upcoming webinars, or click below to learn more about each webinar: ...
(Date:1/30/2019)... , ... January 29, 2019 , ... K&R Negotiations announced ... expert at a special online event titled: Six Ways to Shorten the Sales ... time, February 13, 2019 on the BrightTALK network. , Negotiation expert Kresic will ...
(Date:1/30/2019)... ... January 30, 2019 , ... In 2016, Veronafiere and Vinitaly ... and give recognition to producers whose work focuses entirely on natural, organic and ... Verona, Italy, contemporaneously to the 5StarWines blind tasting organized from April 3rd to ...
(Date:1/24/2019)... , ... January 22, 2019 , ... ... each trial has its own set of assumptions, and RFP creation and management ... evaluating bids is like comparing apples to oranges. These challenges can ultimately lead ...
Breaking Biology Technology:
Cached News: