HOME >> BIOLOGY >> NEWS
UC San Francisco patents method for delivering normal genes in a pill

The first patent for a method of delivering normal genes in a pill to induce the production of insulin in people with diabetes was issued May 1 to the University of California, San Francisco by the United States Patent and Trademark Office.

Sometimes referred to as a "gene pill," the oral delivery of normal genes has been a long-sought and elusive technique. Now, UCSF researchers have successfully demonstrated that raw DNA taken orally can find its way inside cells lining the intestinal tract and prompt those cells to express a protein, such as insulin, even though they are not specialized for that purpose.

"Considerable work still needs to be done before there is an actual gene pill for insulin production, but the patent demonstrates the validity of the concept and promises to spur development of oral delivery of genes to treat a vast number of illnesses," said Stephen S. Rothman, PhD, professor of physiology in the UCSF Schools of Medicine and Dentistry.

The technique holds the potential for providing patients with more than 50 proteins normally secreted by the body into blood and which patients now receive by injection into muscles - including insulin, growth hormones, blood factors for treating hemophilia, and erythropoietin for treating anemia. Rothman expressed confidence that future patent awards to UCSF would cover development of the method for many illnesses.

Genteric, a biotechnology company in Alameda, Calif. has an exclusive, worldwide license agreement with the University to use the method for drug development. The inventors of the technique - Rothman; Michael S. German, MD, associate professor of medicine in the UCSF Hormone Research Institute; and Ira Goldfine, MD, UCSF professor of medicine - along with Michael H. Nantz, PhD, professor of chemistry at UC Davis, are the founders of Genteric.

The research team began studying the technique at UCSF five years ago with funding from the UCSF Foundation and
'"/>

Contact: Bill Gordon
bgordon@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
2-May-2001


Page: 1 2 3

Related biology news :

1. VIB presents its annual results at BIO2004 in San Francisco
2. Invasive cordgrass in San Francisco Bay
3. Life in ice scientist hopes for power in San Francisco
4. Taking the show on the road - Leading researchers to conduct hands-on science symposium for 500 San Francisco area high school students
5. Massive new research effort will map inner workings of cells - San Francisco VA Medical Center chosen to host core laboratory
6. A more accurate measure of exercise ability in older people reported by San Francisco VA Medical Center researchers
7. Futurist research highlights chemists national meeting March 26-30 in San Francisco
8. NASA Exhibit In San Francisco To Show How Space Research Improves Health Care On Earth
9. University Of California-San Francisco Researchers Report Test That Detects Prion Diseases, Illuminates Novel Findings About Infectious Prions
10. University Of California-San Francisco (UCSF) Translational Symposium, September 10, To Focus On HIV Breakthrough And Immune Function
11. HIV Patients Often Experience Viral "Breakthrough," But May Still Remain Healthy, San Francisco Study Finds

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... 2017 Today HYPR Corp. , leading ... component of the HYPR platform is officially FIDO® ... security architecture that empowers biometric authentication across Fortune 500 ... secured over 15 million users across the financial services ... home product suites and physical access represent a growing ...
(Date:3/30/2017)... , March 30, 2017 The research team ... for three-dimensional (3D) fingerprint identification by adopting ground breaking 3D fingerprint ... new realm of speed and accuracy for use in identification, crime ... affordable cost. ... A ...
(Date:3/24/2017)... , March 24, 2017 The Controller General of ... Mr. Abdulla Algeen have received the prestigious international IAIR Award ... Continue Reading ... ... and Deputy Controller Abdulla Algeen (small picture on the right) have received ...
Breaking Biology News(10 mins):
(Date:8/16/2017)... ... 2017 , ... Today, 3Bar Biologics Inc ., the ... funding from an impressive group of investors, including Rev1 Ventures, Maumee Ventures, Ohio ... investment, 3Bar is broadening availability of its groundbreaking offering that uses naturally occurring ...
(Date:8/15/2017)... After spending the past two years building a state-of-the-art ... GeneFo now offers this platform to healthcare stakeholders (hospitals, foundations, biopharma ... and data collection vis a vis their members, under their own ... of this offer. ... ...
(Date:8/15/2017)... ... 2017 , ... Any expert in stem cell research or stem cell medicine ... half a century. Despite their essential roles in human health and regenerative medicine, ... tags developed for this purpose also tag other, more abundant, non-stem tissue cells ( ...
(Date:8/15/2017)... ... August 15, 2017 , ... JULABO USA introduces ... the new website makes it easy to navigate through the site whether you’re ... find detailed product information, educational industry content and visit the company’s social media ...
Breaking Biology Technology:
Cached News: